International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1391
10
1
gregorian
2013
1
1
11
1
online
1
fulltext
en
Dose enhancement effect of gold nanoparticles on MAGICA polymer gel in mega voltage radiation therapy
Radiation Biology
Radiation Biology
تحقيق بديع
Original Research
<p><strong>Background:</strong> Radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools and tissue-like developed to date. Among the special features of this type of dosimeters, is be doped with other elements or chemicals which made them appropriate for investigating of dose enhancement with contrast agents, by high atomic number. <strong>Material and Methods:</strong> In this study, To evaluate dose characteristic of the normoxic polymer gel (MAGICA) such as dose response , dose sensitivity and dose resolution And To find the gold nanoparticles (50 nm) effects of the normoxic polymer gel such as a DEF in mega voltage radiation therapy (18 MV-X ray). Also it is compared by method of Monte Carlo simulation with MCNPX Code. <strong>Results:</strong> The results shown that the MAGICA polymer gel dose response in dose range of 0 to 600 cGy is linear and dose resolution in this range, is less than 0.7 Gy. MAGICA Polymer gel dosimeter response R2 was increased by added gold nanoparticles. Absorbed dose enhancement factor by adding of gold nanoparticles with the 0.1, 0.2, 0.4 mM concentrations was 10%, 2% and 4% respectively. <strong>Conclusion:</strong> In this study, Shielding effect or self absorption happened on 0.2 mM & 0.4 mM. And optimum gold nanopartiles concentration to achieved maximum absorbed doe is 0.1mM, so that is useable for clinical studies.</p>
Dose enhancement, gold nanoparticles, MAGICA, gel dosimetry
55
61
http://ijrr.com/browse.php?a_code=A-10-1-455&slc_lang=en&sid=1
M.
Khadem-Abolfazli
790031947532846007478
790031947532846007478
No
Physics Department, Mazandaran University, Babolsar, Iran
M.
Mahdavi
790031947532846007479
790031947532846007479
No
Physics Department, Mazandaran University, Babolsar, Iran
S.R.M.
Mahdavi
790031947532846007480
790031947532846007480
No
Medical Physics Department, Iran University of Medical Sciences, Tehran, Iran
Gh.
Ataei
golamrezaatae@yahoo.com
790031947532846007481
790031947532846007481
Yes
Para Medical School, Babol University of Medical Sciences, Babol, Iran