en Radiation Biology Radiation Biology تحقيق بديع Original Research <p dir="ltr" style="text-align: justify;"><strong>Background: </strong>&nbsp;The aim of the study was to compare the radioprotective efficacy in the kidney of L-carnitine to that of amifostine. <strong>Materials and Methods:</strong> Thirty three-month-old Wistar albino rats were randomly assigned to four groups: Group 1 (Control); Group 2 (Irradiation alone); Group 3 (amifostine plus irradiation); and Group 4 (L-carnitine before irradiation). The rats in Groups 2, 3, and 4 were irradiated individually with a single dose of 20 Gy to whole abdomen. L-carnitine (300 mg/kg) or amifostine (200 mg/kg) was administered 30 minutes before irradiation. Euthanasia was performed 5 days after irradiation, and kidneys were evaluated histopathologically. <strong>Results:</strong> Dilatation of Bowman&rsquo;s capsule, congestion of blood vessels, and tubular epithelial degeneration were significantly different among the groups (p < 0.05). Pretreatment with both L-carnitine and amifostine reduced the radiation-induced dilatation of Bowman&rsquo;s capsule (p < 0.05), congestion of blood vessels (p < 0.05), and tubular epithelial degeneration (p < 0.05). L-carnitine and amifostine were similar in protective effect. <strong>Conclusion:</strong> L-carnitine was equally effective as amifostine in protecting the kidney against acute irradiation damage.</p> <p></p> Amifostine, histopathology, irradiation, kidney, L-carnitine, radioprotection 317 324 http://ijrr.com/browse.php?a_code=A-10-1-578&slc_lang=en&sid=1 V. Yurut-Caloglu 790031947532846007808 790031947532846007808 Yes Departments of Radiation Oncology, Edirne M. Caloglu 790031947532846007809 790031947532846007809 No Departments of Radiation Oncology, Edirne T. Deniz-Yalta 790031947532846007810 790031947532846007810 No Departments of Pathology, Edirne T. Aktoz 790031947532846007811 790031947532846007811 No Departments of Urology, Edirne D. Nurlu 790031947532846007812 790031947532846007812 No Departments of Radiation Oncology, Edirne N. Kilic-Durankus 790031947532846007813 790031947532846007813 No Departments of Radiation Oncology, Edirne E. Arda 790031947532846007814 790031947532846007814 No Departments of Urology, Edirne G. Turkkan 790031947532846007815 790031947532846007815 No Departments of Radiation Oncology, Edirne O. İnci 790031947532846007816 790031947532846007816 No Departments of Urology, Edirne