International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1396
4
1
gregorian
2017
7
1
15
3
online
1
fulltext
en
Application of computed tomography and magnetic resonance imaging fusion images for delineating gross tumor volume in three-dimensional conformal radiotherapy of nasopharyngeal carcinoma
Radiation Biology
Radiation Biology
تحقيق بديع
Original Research
<div style="text-align: justify;">Background: To evaluate computed tomography (CT) and magnetic resonance imaging (MRI) fusion images for delineating gross tumor volume (GTV) in three-dimensional conformal radiotherapy (3D-CRT) of nasophanrygeal carcinoma (NPC), and compare treatment outcomes between CT- and CT+MRI-based targets. Materials and Methods: A total of 120 NPC patients treated with 3D-CRT were included, in which, 60 each were treated with CT-based and 60 with CT+MRI fusion targets. We explored the clinical application of CT+MRI fusion targets and compared the 1-, 3-, and 5-year survival and relapse rates between both targets. Results: The clinical characteristics and treatment factors were well balanced. The differences in public volume using CT alone in the CT+MRI (Group A) and the CT arm (Group B) were not significant (33.6±2.18 vs. 34.3±2.98, P > 0.05). The public volumes of GTV in the two arms were 49.48±2.46 cm<sup>3</sup> and 33.6±2.18 cm<sup>3</sup> respectively (P < 0.05). CT+MR fusion images did not influence the one-, three-, and 5-year survival rates (100% vs. 98.3%, 85.0% vs. 81.2%, and 73.3% vs. 68.3%, respectively). The three- and 5-year out-of-field progression was reduced in the CT+MRI arm. However, only the difference in 3-year out-of-field relapse rate was significant (3.3% vs. 13.3%; P < 0.05). The incidence of acute toxicities was similar between groups. Conclusion: The variability in GTV delineation in NPC was ascribed to intermodality and not interobserver variability. CT+MR fusion images likely reduced the 3-year out-of-field relapse rate.<br>
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</div>
Nasophanrygeal carcinoma, image fusion, three-dimensional conformal radiation therapy.
251
257
http://ijrr.com/browse.php?a_code=A-10-1-673&slc_lang=en&sid=1
H.
Chen
7900319475328460015474
7900319475328460015474
No
Department of Medical Oncology, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, China
H.
Huang
haixinhuangcn@163.com
7900319475328460015475
7900319475328460015475
Yes
Department of Medical Oncology, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, China
G.
Li
7900319475328460015476
7900319475328460015476
No
Department of Medical Oncology, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, China
D.
Huang
7900319475328460015477
7900319475328460015477
No
Department of Medical Oncology, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, China
S.
Huang
7900319475328460015478
7900319475328460015478
No
Department of Medical Oncology, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, China
Z.
Wang
7900319475328460015479
7900319475328460015479
No
Department of Medical Oncology, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, China