International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1397
1
1
gregorian
2018
4
1
16
2
online
1
fulltext
en
Clinical evaluation of simultaneous integrated boost in brain metastasis patients with helical intensity modulated radiotherapy
Radiation Biology
Radiation Biology
تحقيق بديع
Original Research
<div style="text-align: justify;">Background: This study was performed to assess patient survival and treatment toxicity after helical tomotherapy (HT) with simultaneous integrated boost (SIB) radiotherapy (RT) for cancer patients with one to eight brain metastases (BM) who have been treated with or without surgery. Materials and Methods: A total of 48 brain metastasis (BM) patients were included in this retrospective study between April 2015 and December 2016,. The patients were treated with image-guided intensity modulated radiation therapy (IMRT) on the helical tomotherapy (HT) machine. Whole brain HT as 25 Gy and SIB to metastasis sites as 35 Gy was delivered in 10 fractions. The patient were aged between 50 to 80 years old, volume of the BM was between 6 to 75 cc and the number of brain metastasis was between 1 to 8, Karnofsky Performance Score (KPS) ranged between 50-90 and RPA I-III. Surgery was performed to two patients before RT. The maximum patient follow-up time was 20 months. Results: The primary neurotoxicity observed in patients was grade I- II brain edema related headache and lethargy. In patients who had survived 3- 12 months, KPS improved median score of 20 points and RPA was grade I after six months. Twelve patients had passed away at the end of a 20- month follow-up. Conclusion: HT utilizing SIB treatment for 1- 8 BM was achieved successfully with no significant toxicity. An improvement of performance status indicators of patients following RT was observed.<br>
</div>
Simultaneous integrated boost, brain metastasis, Tomotherapy, radiotherapy.
177
183
http://ijrr.com/browse.php?a_code=A-10-1-715&slc_lang=en&sid=1
A.
Mayadagli
alpdag@hotmail.com
7900319475328460011971
7900319475328460011971
Yes
Department of Radiation Oncology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
H.S
Kiziltan
7900319475328460011972
7900319475328460011972
No
Department of Radiation Oncology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
I.
Kingir Celtik
7900319475328460011973
7900319475328460011973
No
Department of Radiation Oncology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
K.
Berk
7900319475328460011974
7900319475328460011974
No
Department of Radiation Oncology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
E.
Tekce
7900319475328460011975
7900319475328460011975
No
Department of Radiation Oncology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
A.H.
Eris
7900319475328460011976
7900319475328460011976
No
Department of Radiation Oncology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey
H.
Seyithanoglu
7900319475328460011977
7900319475328460011977
No
Department of Radiation Oncology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey