International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1398
3
1
gregorian
2019
6
1
17
3
online
1
fulltext
en
Evaluation of the effects of dental filling material artifacts on IMRT treatment planning in patient with nasopharyngeal cancer
Radiation Biology
Radiation Biology
یادداشت فنی
Technical Note
<div style="text-align: justify;">Background: Presence of artifacts, caused by dental filling high-Z materials (DFM), on intensity-modulated radiation therapy (IMRT) treatment plan CT images may lead to uncertainty in head and neck calculated dose distributions. Hence, the purpose of this study was to investigate the effects of DFM on the IMRT calculated dose distribution and consequent radiobiological derived outcomes for nasopharyngeal cancer patients. Materials and Methods: IMRT optimization of two groups (15 patients in each) of nasopharyngeal cancer (NPC) patients with (group I) and without (group II) dental amalgam was performed by using the Prowess Panther treatment planning system (TPS). For all the patients, target prescribed dose was 70 Gy to planning target volume. We used 3 sets of treatment plans including; nine fields arrangement (F9E) and two plans of seven fields (namely: F7 and F7E) at different angles. The dose volume histograms (DVHs), monitor units (MUs), Homogeneity index (HI), conformity index (CI), Tumor control probability (TCP) and normal tissue complication probability (NTCP) of main organs at risk (OARs) were analyzed. Results: According to the results, the TCP of PTV70 due to presence of dental filling material was significantly decreased (p=0.031). On the other hand received dose by mandible, left cochlea, both eyes and right optic nerve were considerably different between patients with and without artifacts (p<0.05), whereas mandible showed the maximum differences (up to 315.65 cGy) compared to the other studied OARs. Conclusion: Results Presence of dental artifact in patients with nasopharyngeal carcinoma leads to uncertainty in calculated dose of IMRT treatment plans, especially for mandible as an OAR.</div>
Dental Filling Material, Treatment Planning, Intensity Modulated Radiation Therapy, Nasopharyngeal Carcinoma.
485
491
http://ijrr.com/browse.php?a_code=A-10-1-807&slc_lang=en&sid=1
P.
Saadatmand
7900319475328460014315
7900319475328460014315
No
Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
A.
Shanei
shanei@med.mui.ac.ir
7900319475328460014316
7900319475328460014316
Yes
Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
A.
Amouheidari
7900319475328460014317
7900319475328460014317
No
Radiation Oncology Department, Isfahan Milad General Hospital, Isfahan, Iran
I.
Abedi
7900319475328460014318
7900319475328460014318
No
Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran