International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.18869/acadpub.ijrr
en
jalali
1385
12
1
gregorian
2007
3
1
4
4
online
1
fulltext
en
Mathematical description and prognosis of synergistic interaction of radon and tobacco smoking
Radiation Biology
Radiation Biology
تحقيق بديع
Original Research
<span style="font-weight: bold">
Background:</span> Radon and its short-lived decay
products are considered as the important sources of
public exposure to natural radioactivity. The synergistic
interaction between tobacco smoking and radon is
known to be an actual problem. This study has
provided a mathematical description and prognosis of
the carcinogenic effects after combined action of
radon with smoking. <span style="font-weight: bold">Materials and Methods: </span>A
simple mathematical model was adjusted for the
optimization and prognosis of the synergistic
interaction of radon with smoking. The model
postulates that the occurrence of synergism is to be
expected as a result of additional carcinogenic
damage arising from the interaction of sublesions
induced by the two agents under consideration.
<span style="font-weight: bold">Results:</span> The predictions of the model were verified by
comparison with experimental data published by other
researchers. The model appears to be appropriate and
the predictions valid. <span style="font-weight: bold">Conclusion: </span>The suggested
mathematical model predicts the greatest level of
synergistic effect and condition under which this level
is reached. The synergistic effect appeared to decline
with any deviation from the optimal value of the ratio
of carcinogenic effective damages produced by each
agent alone. <br>Iran. J. Radiat. Res., 2007 4 (4): 169-174
Radon, smoking, synergistic interaction, mathematical model, carcinogenesis.
169
174
http://ijrr.com/browse.php?a_code=A-10-1-219&slc_lang=en&sid=1
J.K.
Kim
jkkim@kaeri.re.kr
`79003194753284600665`

79003194753284600665
Yes
S.A.
Belkina
`79003194753284600666`

79003194753284600666
No
V.G.
Petin
`79003194753284600667`

79003194753284600667
No