International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1398
10
1
gregorian
2020
1
1
18
1
online
1
fulltext
en
Comparison of 3D conformal and intensity modulated radiotherapy in early stage oral tongue cancer: dosimetric and radiobiological evaluation
Radiation Biology
Radiation Biology
تحقيق بديع
Original Research
<div style="text-align: justify;">Background: The aim of this study was to compare the dosimetric and radiobiological efficiency of various intensity modulated radiotherapy (IMRT) techniques with 3D conventional radiotherapy (3D-CRT) technique in the treatment of early stage oral tongue cancer. Materials and Methods: This study was performed on 38 CT images of patients who were planned with 3D-CRT and three sets of IMRT treatment plans including five, seven and nine fields with prescribed dose of 66 Gy to planning target volume. The dose volume histograms, homogeneity index (HI), conformity index (CI) and normal tissue complication probability (NTCP) of main organs at risk were derived using Prowess Panther treatment planning system. Results: The results of this study indicated an increase in HI and CI for IMRT plans compared to 3D-CRT. Furthermore, IMRT techniques led to a statistically significant reduction in received dose by mandible (up to 10.10 Gy) and thyroid (up to 13.59 Gy) compared to the conventional technique used; whereas, it led to a statistically significant increase in received dose by parotid glands (up to 7.62 Gy) and brain stem (up to 9.87 Gy). In addition, IMRT increased (up to 12.79%) the probability of occurrence of parotid xerostomia and decreased mandibular complications (up to 7.76%) in comparison to conventional treatment. Conclusions: It can be concluded that IMRT can be more successful in improving oral tongue cancer treatment with more conformity and homogeneity. However, IMRT may not be required for all patients with oral tongue cancer at early stage of the disease.</div>
Oral cavity cancer, oral tongue cancer, 3D conformal radiation therapy, intensity modulated radiotherapy.
33
42
http://ijrr.com/browse.php?a_code=A-10-1-837&slc_lang=en&sid=1
A.
Shanei
7900319475328460015381
7900319475328460015381
No
Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
I.
Abedi
7900319475328460015382
7900319475328460015382
No
Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
P.
Saadatmand
saadatmand.pegah@yahoo.com
7900319475328460015383
7900319475328460015383
No
Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
A.R.
Amouheidari
7900319475328460015384
7900319475328460015384
No
Radiation Oncology Department, Isfahan Milad General Hospital, Isfahan, Iran.
H.
Akbari-Zadeh
hadi.akbari.zadeh@gmail.com,
7900319475328460015385
7900319475328460015385
Yes
Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran