International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1399
4
1
gregorian
2020
7
1
18
3
online
1
fulltext
en
Comparison of different calculation indexes with dose volume histogram parameters for evaluation of radiation treatment plans in gynecologic malignancies
Medical Physics
Medical Physics
تحقيق بديع
Original Research
<div style="text-align: justify;">Background: We aimed to investigate the accordance of Critical Organ Scoring Index (COSI), Conformity Index (CI) and Normal Tissue Complication Probability (NTCP) parameters with Dose Volume Histograms (DVH) used for evaluation of 3 different pelvic radiotherapy plans. Materials and Methods: Ten gynecologic carcinoma patients who underwent adjuvant radiotherapy were enrolled in this study. Treatment plans were created with conformal treatment planning (3DCRT) and intensity modulated radiation therapy (IMRT) to a total dose of 50.4 Gy in 28 fractions. Initially, volume related dose evaluation was done via DVH. Subsequently, HI, CI, COSI and NTCP for selected normal tissues were calculated for each plan and compared with DVH parameters. Finally, a graphical demonstration was evaluated to see if the results were in accordance with DVH. Results: CI results were statistically significant in favor of IMRT (p<0.001). Rectum V<sub>40Gy </sub>decreased with 9IMRT compared to 3DCRT and 7IMRT (p=0.013 and p=0.013). V<sub>40Gy</sub> for bladder was also lower with 9IMRT compared with 3DCRT and 7IMRT (p=0.005 and p=0.012). COSI calculations revealed better small intestine protection in IMRT plans similar with DVH (p=0.005 and p=0.022). Femoral heads were better protected with IMRT plans were better compared to 3DCRT in NTCP calculations (p=0.002). Normal tissue protection was worst with 3DCRT via both DVH and COSI evaluations (p=0.001 and p<0.001 respectively). Conclusion: Using the indexes in this study to decide the most appropriate plan among multiple treatment plans in gynecologic cancer patients will be timesaving and easier in comparison with evaluating the DVH of every alternative plan.</div>
Gynecological radiotherapy, treatment planning, dosimetric evaluation.
477
486
http://ijrr.com/browse.php?a_code=A-10-2055-34&slc_lang=en&sid=1
A.
Inal
aysuntoy@yahoo.com
7900319475328460017248
7900319475328460017248
Yes
Department of Radiation Oncology, University of Health Sciences Antalya Training and Research Hospital 07100, Antalya, Turkey
E.
Duman
7900319475328460017249
7900319475328460017249
No
Department of Radiation Oncology, University of Health Sciences Antalya Training and Research Hospital 07100, Antalya, Turkey
E.E.
Ozkan
7900319475328460017250
7900319475328460017250
No
Department of Radiation Oncology, School of Medicine, Suleyman Demirel University, Turkey