International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1399
4
1
gregorian
2020
7
1
18
3
online
1
fulltext
en
Effects of adrenomeduline and ramp2 on the lung of mice exposed to total body radiation
Radiation Biology
Radiation Biology
تحقيق بديع
Original Research
<div style="text-align: justify;">Background: Adrenomedullin (AM) and its receptor, receptor activity-modifying protein (RAMP) 2 have pleiotropic regulatory functions in normal tissue and cancer tissue. AM is produced and secreted both numerous stromal cells and tumor cells. This study aims to investigate a possible role of AM and RAMP2 in the radiation exposure in the normal lung tissue. Materials and Methods: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice were subjected to a 500 cGy single-dose radiation exposure in the total body radiation device and lung tissues were collected. 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. Results: The general histology and the immunohistochemistry of the tissue samples prepared with anti- AM, anti–RAMP2, and monoclonal antibodies were investigated, yielding a statistically significant increase for AM on day 3 and for RAMP2 on day 1 after radiation exposure. Conclusion: The observed increase of AM and RAMP2 concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy. </div>
AM, RAMP2, radiation, lung, carcinogens.
571
578
http://ijrr.com/browse.php?a_code=A-10-1-864&slc_lang=en&sid=1
M.K.
Ozbilgin
kemalozbilgin@yahoo.com
7900319475328460016141
7900319475328460016141
No
Department of Histology and Embryology, Celal Bayar University School of Medicine, Manisa, Turkey
G.Z.
Karaman
7900319475328460016142
7900319475328460016142
No
Department of Histology and Embryology, Celal Bayar University School of Medicine, Manisa, Turkey
S.
Gencur
7900319475328460016143
7900319475328460016143
No
Department of Histology and Embryology, Celal Bayar University School of Medicine, Manisa, Turkey
E.
Gumustepe
7900319475328460016144
7900319475328460016144
No
Department of Radiation Oncology, Ankara University School of Medicine, Ankara, Turkey
C.
Kurtman
7900319475328460016145
7900319475328460016145
No
Department of Radiation Oncology, Ankara University School of Medicine, Ankara, Turkey