International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1399
7
1
gregorian
2020
10
1
18
4
online
1
fulltext
en
Biokinetic modelling of 89-Zr-labelled monoclonal antibodies for dosimetry assessment in humans
Medical Physics
Medical Physics
تحقيق بديع
Original Research
<div style="text-align: justify;">Background: Monoclonal antibodies have confirmed their merit as biotherapeutics across a wide spectrum of diseases, including cancer, heart disease, infection, and immune disorders. Materials and Methods: The dynamics of <sup>89</sup>Zr-labelled monoclonal antibodies (MAb) after injection into the human body are modelled. This modified biokinetic model can be used for dose assessment not only for <sup>89</sup>Zr-labelled MAb tumour visualization but also for diagnostic and radiation therapy with other MAb-labelled radionuclides. The created modified biokinetic model is based on experimental data from the literature. The cumulative <sup>89</sup>Zr activity in organs and tissues per Bq of administered activity is calculated with the WinAct program. Results: For the organs receiving the highest radiation exposure, the average absorbed doses were estimated with IDAC 2.1 software. The results from the modelled calculations are compared with new published experimental diagnostic results from real patients. The calculations reveal that the organs which received the highest dose were the spleen, liver, kidneys, and red bone marrow (doses of 1.54, 1.33, 0.81 and 0.82 mGy/MBq, respectively). In the modified biokinetic model, the organs exhibiting the highest dose were the liver, gallbladder wall, spleen, pancreas, and kidneys (at 1.07, 0.77, 0.70, 54 and 0.44 mGy/MBq, respectively), when the injection was associated with monoclonal antibodies. Conclusion: The developed biokinetic model is in good agreement with direct measurements and can be considered a first step for simulating the radiopharmaceutical dosimetry of the <sup>89</sup>Zr isotope.</div>
PET visualization, internal exposure, zirconium-89, monoclonal antibodies, absorbed dose.
825
833
http://ijrr.com/browse.php?a_code=A-10-2055-69&slc_lang=en&sid=1
H.M.H.
Zakaly
h.m.zakaly@azhar.edu.eg
7900319475328460017386
7900319475328460017386
Yes
Department of Experimental Physics, Institute of Physics and Technology, Ural Federal University, Yekaterinburg, Russia
M.Y.A.
Mostafa
7900319475328460017387
7900319475328460017387
No
Department of Experimental Physics, Institute of Physics and Technology, Ural Federal University, Yekaterinburg, Russia
M.
Zhukovsky
7900319475328460017388
7900319475328460017388
No
Minia University, Faculty of Science, Department of Physics, El-Minia, Egypt