International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1383
3
1
gregorian
2004
6
1
2
1
online
1
fulltext
en
Effects of Pentoxifylline on the healing of irradiated wounds in pig skin
Radiation Biology
Radiation Biology
تحقيق بديع
Original Research
<p><strong>Background: </strong>This study was designed to investigate the efficacy of Pentoxifylline (PTX) in the treatment of irradiated wounds. </p><p><strong>Materials and Methods: </strong>Ten female pigs of the Large White strain were used in these <br>investigations. Six skin fields, 4 * 4 cm and separated from each other by 4 cm, were marked out on each flank and those on left flank were irradiated with 18Gy single dose of 250 kV X-rays. The animals were then randomly allocated to one of three groups. Ten weeks after irradiation a 2 * 2 cm surgical wound was produced, by removing the skin up to facia level, at the centre of the original skin fields. This was done on both irradiated (left flank) and unirradiated control (right flank) fields. Two groups of animals were treated by daily oral gavaging, with 13.3mg/kg/day PTX dissolved in 10 ml water while a group of control animals received only 10 ml water by oral gavage as placebo. PTX treatment started either two weeks prior to wounding or at the day of wounding. The progression of the healing of excision wounds were evaluated periodically by assessment of wound contraction. </p><p><strong>Results and Conclusion: </strong>Overall, irradiated wounds healed much slower than unirradiated wounds. While PTX treatment had no effect on the healing rate of unirradiated wounds it appeared that treating the animals with PTX delayed the healing of irradiated wounds. This was true whether PTX treatment started two weeks prior to or at the time of wounding. <i>Iran </i><i>. J. Radiat. Res., 2004 2 (1): 1-7 </i></p>
, wound healing, Pentoxifylline, pig skin
1
7
http://ijrr.com/browse.php?a_code=A-10-1-35&slc_lang=en&sid=1
M. Rezvani
79003194753284600102
79003194753284600102
Yes
G.A. Ross
79003194753284600103
79003194753284600103
No
K. Lamb
79003194753284600104
79003194753284600104
No
J. H. Wilkinson
79003194753284600105
79003194753284600105
No