International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1400
4
1
gregorian
2021
7
1
19
3
online
1
fulltext
en
Histogram analysis of intravoxel incoherent motion and dynamic contrast-enhanced MRI with the two-compartment exchange model in glioma
Radiobiology
Radiobiology
تحقيق بديع
Original Research
<div style="text-align: justify;">Background: Since different grades of gliomas have different treatment programs, prognosis, and survival rates, it’s important to differentiate them effectively. Intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced (DCE) with the two-compartment exchange model (2CXM) have showed great potential for identifying the brain tumors. Materials and Methods: Thirty-nine patients with glioma underwent IVIM and DCE imaging at 3.0T. Quantitative parameters (mean, median, 10<sup>th</sup>, 25<sup>th</sup>, 75<sup>th</sup> and 90<sup>th</sup> percentiles) from IVIM (apparent diffusion coefficient (ADC), D, D*, f, and their product fD*) and DCE (v<sub>p</sub>, v<sub>e</sub>, PS, and F<sub>p</sub>) were analyzed. The independent Student’s t-test and Mann-Whitney U-tests were used to assess whether these parameters could distinguish low- from high-grade glioma. Receiver-operating characteristic (ROC) curve analysis and Delong test were performed to determine and compare the diagnostic efficiency of IVIM and DCE parameters in differentiating low- and high-grade gliomas, respectively. Results: Various histogram statistics of IVIM and DCE parameters could differentiate different grades of glioma. v<sub>e</sub> and v<sub>p</sub> generally yielded higher area under the curve (AUC) values than IVIM parameters, and the differences in AUC values of v<sub>e</sub>_mean and IVIM parameters had a statistical significance. Although DCE had higher AUC values than IVIM, they didn’t reach statistical significance. Conclusions: v<sub>e</sub> was the best parameter in differential diagnosis of gliomas. IVIM had the similar diagnosis performance with DCE, and both IVIM and DCE-MRI parameters can be used for preoperative grading of gliomas.</div>
Apparent diffusion coefficient, Dynamic contrast-enhanced, Glioma, Intravoxel incoherent motion, D value.
505
514
http://ijrr.com/browse.php?a_code=A-10-2188-23&slc_lang=en&sid=1
F.
Xing
7900319475328460020218
7900319475328460020218
No
Department of Radiology, Renmin Hospital of Wuhan University, Wuhan 430060, P. R. China
G.
Wu
wuguangy2002@163.com
7900319475328460020219
7900319475328460020219
Yes
Radiology Department, Shenzhen University General Hospital and Shenzhen University Clinical Medical Academy, Shenzhen, 5180554, P. R. China