International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1400
4
1
gregorian
2021
7
1
19
3
online
1
fulltext
en
Structural evaluation of Parotid gland in post radiotherapy oral cancer patients: A prospective study
Radiobiology
Radiobiology
تحقيق بديع
Original Research
<div style="text-align: justify;">Background: To evaluate structural variation of the parotid gland in post-radiotherapy oral carcinoma patients. Material and Methods: 52 patients (33 males, 19 females) with histologically confirmed cancer of head and neck region were enrolled. All the patients underwent intensity modulated radiotherapy (IMRT) with linear accelerator. A quantitative analysis was conducted with the help of contrast enhanced computed tomography (CECT) scan regarding the changes in the volume and density of the parotid glands (PGs) along with the assessment of their interrelationship in relation to the mean dose applied to the glands. The evaluations were done immediately after radiotherapy, and after 2 and 3 years. Results: Parotid size reduction was observed in 77.77 % of cases immediately after radiotherapy with a mean dose of 26.66 Gy applied to the parotid glands. Parotid shrinkage reduced to 61.5 % cases three years post radiotherapy. High density changes were revealed by 69.2 % cases immediately after radiotherapy with a mean dose of 34.53 Gy applied to these parotid glands. Low density changes were revealed by 48.1 % cases after 2 years follow up which further reduced to 25 % at three years follow up. Conclusion: There was evidence of structural variation in the PGs during the course of IMRT which was significantly related with the mean dose applied to them. There were high density changes and low density changes immediately after radiotherapy and 2-3 years post-radiotherapy respectively. Further there was volumetric shrinkage post-radiotherapy which shows recovery 2 and 3 years post-radiotherapy.</div>
Radiotherapy, oral cancer, IMRT, parotid gland density, parotid gland size, xerostomia.
521
529
http://ijrr.com/browse.php?a_code=A-10-2188-25&slc_lang=en&sid=1
X.
Hao
7900319475328460018865
7900319475328460018865
No
Department of Imaging,Yuncheng Central Hospital, Yuncheng, Shanxi Province, 044000, China
C.
Zhang
7900319475328460018866
7900319475328460018866
No
Department of Imaging,Yuncheng Central Hospital, Yuncheng, Shanxi Province, 044000, China
X.
Lv
lxbdbjlzy@sina.com
7900319475328460018867
7900319475328460018867
Yes
Department of Medical Imaging, Linfen Central Hospital, No. 17 Jiefang West Road, Linfen, Shanxi Province, 041000, China