International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1400
4
1
gregorian
2021
7
1
19
3
online
1
fulltext
en
Successful treatment of a patient with an EGFR-mutated pulmonary adenocarcinoma and a history of uremia with erlotinib after gefitinib-induced kidney dysfunction: a case report
Radiobiology
Radiobiology
مطالعه موردي
Case Report
<div style="text-align: justify;">A 48-year-old male patient with a history of uremia was diagnosed with pulmonary adenocarcinoma based on a computed tomography (CT) scan and biopsy. In addition, an epidermal growth factor receptor (EGFR) exon 19 deletion was identified by gene detection. Surgical treatment was not acceptable because of his poor physical condition, so he was treated with gefitinib. Kidney function deteriorated and the serum urea nitrogen and creatinine levels were increased. Two weeks after discontinuing treatment with gefitinib, kidney function gradually returned to normal and was treated with erlotinib. This is an unusual case involving a patient with EGFR-mutated pulmonary adenocarcinoma and a history of uremia who was successfully treated with erlotinib after gefitinib-induced kidney dysfunction.</div>
Epidermal growth factor receptor, pulmonary adenocarcinoma, Erlotinib, gefitinib, kidney function.
749
753
http://ijrr.com/browse.php?a_code=A-10-2188-50&slc_lang=en&sid=1
L.
Zhou
LinmeiZhou@outlook.com
7900319475328460020490
7900319475328460020490
Yes
Respiratory ward 2, PCCM, Affiliated Hospital of Zunyi Medical University, Zunyi City, 563003, China
Z.
Chen
7900319475328460020491
7900319475328460020491
No
Respiratory ward 2, PCCM, Affiliated Hospital of Zunyi Medical University, Zunyi City, 563003, China