International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1400
10
1
gregorian
2022
1
1
20
1
online
1
fulltext
en
Mitigation of 131-I induced oxidative stress by supplementation of turmeric and green cardamom in thyroid patients
Radiobiology
Radiobiology
تحقيق بديع
Original Research
<div style="text-align: justify;">Background: The use of <sup>131</sup>I in thyroid diseases is responsible for oxidative stress due to increased production of reactive oxygen species that may lead to multiple disorders in human. Purpose of this study was to mitigate the oxidative stress, generated by <sup>131</sup>I therapy, by supplementation of phytoprotectants. Materials and Methods: After eliminating absconders, 97 volunteers of benign and malignant hyperthyroid diseases viz. control (n=42), standard (n=23), turmeric (n=19) and green cardamom (n=13) groups participated in this study. Vitamins were administered orally in standard group while turmeric (Curcuma longa) and green cardamom (Eletteria cardamomum) as phytoprotectants were given orally in the respective groups, 5 days before <sup>131</sup>I therapy. The malondialdehyde (MDA) was measured in serum before (baseline), at 3-hours and after 2-weeks of <sup>131</sup>I administration. Results: After radioactive iodine therapy (RAIT), there was a continuous decline of serum MDA in vitamin group (3.57 to 2.64 µmol/L) in contrast to the control, where there was a ceaseless rise (3.01 to 3.69 µmol/L) in the oxidative stress in terms of MDA. In akin to the standard group of vitamins, there was incessant decrease in both the treatment groups of green cardamom (3.55 to 2.89 µmol/L) and turmeric (3.45 to 2.06 µmol/L). The turmeric was proved as better phytoprotectant. Conclusion: The turmeric and green cardamom are good scavengers of free radicals and can be used as supplements along with <sup>131</sup>I, in thyroid patients as radioprotective agents. The turmeric is more potent radioprotectant as compared to green cardamom.</div>
Turmeric, green cardamom, radioprotectants, malondialdehyde, oxidative stress.
29
36
http://ijrr.com/browse.php?a_code=A-10-2188-57&slc_lang=en&sid=1
A.
Rakha
drarmalik45@gmail.com
7900319475328460020706
7900319475328460020706
Yes
Department of Biochemistry, Punjab Medical College, Faisalabad, Pakistan
Kh.
Rehman
7900319475328460020707
7900319475328460020707
No
Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan
M.
Babar Imran
7900319475328460020708
7900319475328460020708
No
Pakistan Institute of Nuclear Medicine, Faisalabad, Pakistan
M.
Shahid
7900319475328460020709
7900319475328460020709
No
Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan
N.
Jahan
7900319475328460020710
7900319475328460020710
No
Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan