International Journal of Radiation Research

en Combination of ultrasound with BRAF V600E gene detection for the evaluation of aggressive behavior of papillary thyroid microcarcinoma Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: The Japanese clinical guidelines and the 2015 American Thyroid Association Management Guidelines recommend that indolent papillary thyroid microcarcinoma (PTMC) be monitored actively and that patients with aggressive PTMC immediately undergo surgery. This study aimed to establish a stage model and provide a reference for the preoperative identification of aggressive PTMC and indolent PTMC, which might guide the treatment of PTMC. Materials and Methods: Risk factors for the aggressive PTMC were identified through multivariate logistic regression analysis. According to the regression coefficient, each risk factor was assigned a risk score; thereafter, a risk score (RS) model and a stage model were established. Results: The tumor’s largest diameter > 6 mm, BRAFV600E (v-Raf murine sarcoma viral oncogene homolog B1, V600E) mutation, ultrasound-suspected lymph node metastasis, ultrasound-suspected extrathyroidal extension, and microcalcification were identified as risk factors for aggressive PTMC. The stage model was divided into three stages: stage I (RS=0.0; predictive probability for PTMC aggressiveness <10%), stage II (RS=1.0–2.3; predictive probability for PTMC aggressiveness, 10–50%), stage III (RS=3.2–7.6; predictive probability for PTMC aggressiveness, >50%). Based on the abovementioned results, stages I and II were considered to be probably indolent PTMC, and stage III was considered as probably aggressive PTMC. Conclusion: We suggest that patients with stages I and II PTMC be recommended for active surveillance, while those with stage III PTMC be recommended for immediate surgery.</div> Papillary thyroid microcarcinoma, ultrasound, BRAFV600E, aggressive. 389 395 http://ijrr.com/browse.php?a_code=A-10-1-921&slc_lang=en&sid=1 W. Liu 7900319475328460021802 7900319475328460021802 No Department of Ultrasound, the Second Hospital of Anhui Medical University, 230601, HeFei, AnHui, China M. Peng 714200630@qq.com 7900319475328460021803 7900319475328460021803 Yes Department of Ultrasound, the Second Hospital of Anhui Medical University, 230601, HeFei, AnHui, China F. Jiang 7900319475328460021804 7900319475328460021804 No Department of Ultrasound, the Second Hospital of Anhui Medical University, 230601, HeFei, AnHui, China S.Y. Wang 7900319475328460021805 7900319475328460021805 No Department of Head and Neck, the First Affiliated Hospital of USTC West District, 230000, HeFei, AnHui, China J.J. Liu 7900319475328460021806 7900319475328460021806 No Department of Head and Neck, the First Affiliated Hospital of USTC West District, 230000, HeFei, AnHui, China K. Tao 7900319475328460021807 7900319475328460021807 No Department of Head and Neck, the First Affiliated Hospital of USTC West District, 230000, HeFei, AnHui, China J. He 7900319475328460021808 7900319475328460021808 No Department of Head and Neck, the First Affiliated Hospital of USTC West District, 230000, HeFei, AnHui, China