International Journal of Radiation Research

en Do auto-planning intensity modulated radiotherapy treatment plans for central lung cancer have improved quality over manual plans? Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: To investigate the performance of Auto-Planning intensity modulated radiation therapy (IMRT) plans for patients with central lung cancer and to determine whether Auto-Planning improves the quality of IMRT plans. Materials and Methods: Thirty patients treated with IMRT for central lung cancer were replanned with the Pinnacle3 Auto-Planning module. The dose distribution at the target, organ at risk (OAR) sparing, dose falloff in the five rings outside of target, monitor units (MUs), planning time, and dosimetric verification in terms of the γ passing rate were evaluated. A Wilcoxon signed-rank test was performed to assess differences between groups (p<0.05). Results: The target homogeneity in the Auto-Planning were significantly better than that in the manual plans, the target conformity in both groups were similar. The Auto-Planning plans yielded lower V5, V10, V13, V20, V30, V40 values, mean lung dose of total lung (p<0.01), and Dmax of spinal cord (p<0.01) and V30 of heart (p<0.01). No significant difference was found for the V40 of the heart (p=0.203). The Auto-Planning module reduced the Dmean, D2 and D5 values in all rings outside of PTV. The planning time was 52.5% shorter for Auto-Planning plans than for manual plans (p<0.01), and 4.4% additional MUs were required with Auto-Planning. No difference was observed for the γ passing rate. Conclusion: Auto-Planning for central lung cancer could improve homogeneity of target volumes, significantly delivery lower dose to OARs and steeper dose falloff outside of tumors while reducing the planning time.</div> Pinnacle auto-planning, IMRT, lung cancer. 499 505 http://ijrr.com/browse.php?a_code=A-10-1-936&slc_lang=en&sid=1 H. Chen 7900319475328460021722 7900319475328460021722 No Institute of Modern Physics, Fudan University, Shanghai, China Y. Shao 7900319475328460021723 7900319475328460021723 No Institute of Modern Physics, Fudan University, Shanghai, China H. Wang 7900319475328460021724 7900319475328460021724 No Institute of Modern Physics, Fudan University, Shanghai, China H. Gu 7900319475328460021725 7900319475328460021725 No Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China Y. Duan 7900319475328460021726 7900319475328460021726 No Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China A. Feng 7900319475328460021727 7900319475328460021727 No Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China Y. Huang 7900319475328460021728 7900319475328460021728 No Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China C. Chen xzyong12vip@sina.com 7900319475328460021729 7900319475328460021729 Yes Institute of Modern Physics, Fudan University, Shanghai, China Z. Xu chychen@fudan.edu.cn 7900319475328460021730 7900319475328460021730 No Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China