en Radiation Biology Radiation Biology گزارش کوتاه Short Report <div style="text-align: justify;"><span style="font-size:12pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="tab-stops:1.029in"><span style="unicode-bidi:embed"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-IN" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-IN">The present study was carried out to estimate the effect of Ultraviolet B (UVB) radiation on the thyroid gland of female Wistar rats.</span></span></span> <span lang="en-IN" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-IN">Materials and Methods</span></span></span></span></span></span><span lang="en-IN" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-IN">: </span></span></span></span></span><span lang="en-IN" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-IN">Female rat (n=24) of 12-16 weeks with body weight of 130-150gm were housed in standard cages, fed sterilized food and water ad libitum. Animals were divided into four groups. Ist group was control, IInd group was exposed to 280 nm of UVB radiation for 2 h/day. IIIrd group was exposed to 280 nm of UVB radiation for 2 h/day and 25 mg/kg body weight curcumin orally. IVth group was given 25 mg/kg body weight curcumin orally. All treatments last for 15 days. </span></span></span><span lang="en-IN" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-IN">Results</span></span></span></span></span></span><span lang="en-IN" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-IN">:</span></span></span></span></span> <span lang="en-IN" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-IN">The results showed that</span></span></span><span lang="en-IN" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-IN"> UVB radiation decreased body and </span></span></span><span lang="en-IN" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-IN">thyroid gland weight. </span></span></span><span lang="en-IN" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-IN">However at the same time increased T3, T4, FT3, and FT4 levels (p<0.01: p<0.001; p<0.05) and decreased the level of TSH (p<0.001) significantly. Histologically, UVB radiation-damaged follicular cells and disappeared colloid fluid, and decreased follicle diameter significantly (p<0.01). </span></span></span><span lang="en-IN" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-IN">Conclusion</span></span></span></span></span></span><span lang="en-IN" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-IN">:</span></span></span></span></span> <span lang="en-IN" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-IN">It is concluded that UVB radiation generates imbalance in thyroid hormones and induced hyperthyroidism on female Wistar rat and curcumin play protective role in hyperthyroidism against UVB radiation.</span></span></span></span></span></span></span></span></span></span></span></div> UVB radiation, hormones, hyperthyroidism, curcumin, female Wistar rat. 507 510 http://ijrr.com/browse.php?a_code=A-10-1-937&slc_lang=en&sid=1 G. Rai 7900319475328460021779 7900319475328460021779 No Department of Zoology, Dr Harisingh Gour (A Central University) Vishwavidyalaya, Sagar (M.P.), India P. Mahobiya 1607payal@gmail.com 7900319475328460021780 7900319475328460021780 Yes Department of Zoology, Dr Harisingh Gour (A Central University) Vishwavidyalaya, Sagar (M.P.), India