en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">To investigate the value of 3.0T magnetic resonance perfusion-weighted imaging (PWI) in the preoperative differential diagnosis and grading assessment of gliomas. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods:</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> The PWI features of 23 single brain metastases and 73 gliomas (32 low-grade and 41 high-grade) were retrospectively analyzed with postoperative pathological findings. The cerebral blood volume (CBV) values of the tumour parenchyma, the peritumoral oedema area and the contralateral normal brain tissue were measured, and the relative CBV (rCBV) values were calculated and statistically analysed. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results:</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> A total of 96 patients, comprising 66 men and 30 women with a mean age of 47 &plusmn; 11 years, were included in the study. The time-signal curves of gliomas of different grades obtained by magnetic resonance perfusion have different characteristics. The rCBV values for tumor parenchyma and peritumoral edema were higher in the high-grade glioma group than in the low-grade glioma group and the single brain metastasis group ([6.01 &plusmn; 1.64] vs [2.16 &plusmn; 0.87] vs [4.37 &plusmn; 1.03]) and ([1.82 &plusmn; 0.47] vs [0.79 &plusmn; 0.34] vs [0.81 &plusmn; 0.21]), and the differences were significant (p < 0.05). The rCBV value of the tumour parenchyma in the single brain metastasis group was higher than that in the low-grade glioma group ([4.37 &plusmn; 1.03] vs [2.16 &plusmn; 0.87]), and the difference was significant (p < 0.05). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Magnetic resonance PWI has high clinical value in the preoperative diagnosis and grading evaluation of gliomas.</span></span></span></span></span></span></span></span></span></div> Perfusion Weighted MRI, glioma, neoplasm grading, diagnosis. 573 578 http://ijrr.com/browse.php?a_code=A-10-1-1210&slc_lang=en&sid=1 L. Zhang 7900319475328460027903 7900319475328460027903 No Department of Magnetic Resonance Imaging, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou City 061001, Hebei Province, China M. Sun Smin_1201@163.com 7900319475328460027904 7900319475328460027904 Yes Department of Magnetic Resonance Imaging, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou City 061001, Hebei Province, China