International Journal of Radiation Research

en A New hybrid radiotherapy technique for non-small cell lung cancer: Is more effective for functional lung sparing Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: The Conventional thoracic radiotherapy planning ignores regional pulmonary function changes. This study aimed to evaluate the beneficial effect of a new hybrid three-dimensional conformal radiation therapy (3DCRT)/intensity-modulated radiation therapy (IMRT) technique. Materials and Methods: Thirty patients with non-small cell lung cancer were included in this study. Four protocols were designed for each patient: anatomical IMRT (A-IMRT, based on the total lung), functional IMRT (F-IMRT), pure IMRT (O-IMRT) plan, and hybrid 3DCRT/IMRT plan (H-3DCRT/IMRT), which were based on the functional lung. The opposing pair of fields in the O-IMRT and H-3DCRT/IMRT protocols provide 2/9 and 1/2 of radiation dose, respectively. The planning target volume coverage, dose in both total and functional lungs, maximum spinal cord dose, mean esophagus dose, mean heart dose, homogeneity index (HI), conformity index (CI), and treatment monitor units (MUs) were compared in this study. Results: The V5, V20, and mean dose (Dmean) of the both total and functional lungs in the H-3DCRT/IMRT protocol were the lowest among the four treatment regimes. For D2, D98, HI, and CI, the A-IMRT protocol was superior to the H-3DCRT/IMRT protocol. Compared with the A-IMRT protocol, the F-IMRT protocol achieved significantly lower V5, V20, and Dmean for functional lungs, but showed worse HI, CI, and maximum dose of spinal cord. The H-3DCRT/IMAT protocol significantly reduced the maximum spinal cord dose and MUs. Conclusions: The H-3DCRT/IMAT plan based on functional lung images appeared to be better than conventional F-IMRT in preserving functional lung without compromising on HI and CI in NSCLC patients.</div> non-small-cell lung carcinoma, three dimensional conformal radiotherapy, intensity-modulated radiotherapy, respiratory function tests. 609 616 http://ijrr.com/browse.php?a_code=A-10-1-1216&slc_lang=en&sid=1 C. Chen 7900319475328460027930 7900319475328460027930 No Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan, 430071, Hubei, China G. Chen 7900319475328460027931 7900319475328460027931 No Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan, 430071, Hubei, China R. Fang 7900319475328460027932 7900319475328460027932 No Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan, 430071, Hubei, China Y. Xu 7900319475328460027933 7900319475328460027933 No Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan, 430071, Hubei, China H. Liu liuhui69@hotmail.com 7900319475328460027934 7900319475328460027934 Yes Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan, 430071, Hubei, China Z. Liao zliao@whu.edu.cn, 7900319475328460027935 7900319475328460027935 No Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Wuhan, 430071, Hubei, China