International Journal of Radiation Research

en Spread-out of Bragg peak of proton beam using Au nanoparticles: A Monte Carlo simulation study Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Proton Beam Therapy (PBT) provides significantly enhanced dose distribution and dosimetric advantages compared to photon beam radiation therapy. In PBT, the Spread-Out Bragg Peak (SOBP) is crucial for achieving a conformal dose distribution within the target volume. We propose a novel method for creating SOBP by passing the beam through slabs containing varying concentrations of Au nanoparticles (NPs). Materials and Methods: GEANT4.10.6 was used for Monte Carlo tracking of proton beams within the slabs and water phantom. Various arrangements of layers containing AuNPs, with concentrations ranging from 1 to 35 M, were positioned along the path of the proton beams with an energy of 200 MeV. The most suitable arrangement of the slabs was determined based on the width of the SOBP and the dose variation in the SOBP plateau. Results: In the most suitable quintuple and sextuple arrangements of slabs, the width of the Bragg peak increases within the range of 45 to 65 mm. Furthermore, in these arrangements, variations in dose within the SOBP plateau are less than 5%. Conclusion: The arrangement of slabs with different AuNP concentrations is a stationary device placed along the beamline. This setup requires no additional time considerations and can be readily incorporated within the clinical setting.</div> Bragg peak, Proton, Au nanoparticle, Monte Carlo, SOBP. 697 701 http://ijrr.com/browse.php?a_code=A-10-1-1228&slc_lang=en&sid=1 A.S. Talebi 7900319475328460028010 7900319475328460028010 Yes Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran H. Rajabi 7900319475328460028011 7900319475328460028011 No Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran