en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">This study aims to investigate the pituitary MRI morphological parameters and alterations in 25-hydroxyvitamin D3 [25-(OH) D3], free thyroxine (FT4), and sex hormone levels in female children with central precocious puberty (CPP) and assess their clinical relevance. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">From February 2022 to February 2023, 46 female children with CPP and 46 healthy controls were included. Pituitary MRI morphological parameters, 25-(OH) D3, FT4, and sex hormone levels were compared. Diagnostic values of each parameter were assessed. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Patients with CPP exhibited higher pituitary height and altered morphology compared to controls, with a higher proportion in grades 4 and 5 (P < 0.05). Coronal and sagittal dimensions were increased, while coronal width was decreased in the study group (P < 0.05). Levels of E2, LH, FSH, and FT4 were elevated, while 25-(OH) D3 was reduced in CPP patients (P < 0.05). Pituitary height, coronal height, and hormone levels showed high diagnostic value for CPP, with AUC values ranging from 0.811 to 0.886. Combined diagnosis using these indicators improved AUC to 0.909. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">In female children with CPP, significant differences exist in pituitary MRI morphological parameters, sex hormones, 25-(OH) D3 and FT4 levels, providing valuable diagnostic insights for CPP.</span></span></span></span></span></span></span></span></span></div> Central precocious puberty, pituitary MRI, 25-Hydroxyvitamin D3, Free phyroxine, sex hormones, dagnostic imaging. 0 0 http://ijrr.com/browse.php?a_code=A-10-1-1254&slc_lang=en&sid=1 Z. Zhang 7900319475328460028496 7900319475328460028496 No Department of Radiology, Hainan Women & Children's Medical Center, Haikou, China Y. Wei 7900319475328460028497 7900319475328460028497 No Department of Radiology, Hainan Women & Children's Medical Center, Haikou, China Y. Zhang 7900319475328460028498 7900319475328460028498 No Department of Neonatology, Hainan Women & Children's Medical Center, Haikou, China J. Wen 7900319475328460028499 7900319475328460028499 No Department of Clinical Laboratory, Hainan Women & Children's Medical Center, Haikou, China Y. Lin Linyi88431@163.com 7900319475328460028500 7900319475328460028500 Yes Department of Radiology, Hainan Women & Children's Medical Center, Haikou, China