International Journal of Radiation Research

en Application value of MRI radiomics in differential diagnosis of osteoporotic and malignant neoplastic vertebral compression fractures Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: To explore the radiomics features of osteoporotic and malignant neoplastic vertebral compression fractures (VCFs), and to analyze the application value of radiomics in differential diagnosis of osteoporotic and malignant neoplastic VCFs. Materials and Methods: Fifty-one patients with VCFs caused by malignant tumors and forty-nine patients with osteoporosis-induced VCFs treated in the Xiaoshan Hospital Affiliated to Hangzhou Normal University from January 2020 to June 2023 were retrospectively collected into a training set (70 cases) and a verification set (30 cases) according to a stratified random sampling design and a 7:3 ratio. The radiomics parameters of T2WI images of the diseased vertebral bodies were extracted, and the parameters with statistical differences were screened out by dimensionality reduction, so as to build a prediction model. Receiver operating characteristic (ROC) curves were drawn to evaluate the differential diagnosis performance of radiomics for the etiology of vertebral fractures. Results: Eight radiomics features were obtained after dimensionality reduction using the LASSO algorithm. The constructed model was effective in differentiating osteoporotic and malignant neoplastic VCFs, with an area under the ROC curve (AUC) of 0.95; while the AUC for the validation set was 0.84. Conclusions: The radiomics features of T2WI images of vertebral fractures have high efficiency in the differential diagnosis of fracture etiology.</div> agnetic resonance imaging, osteoporosis, compression fractures, neoplasms. 927 931 http://ijrr.com/browse.php?a_code=A-10-1-1259&slc_lang=en&sid=1 Y. Li 7900319475328460028608 7900319475328460028608 No Department of Radiology, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, Zhejiang, 310000, China H. Zhang 7900319475328460028609 7900319475328460028609 No Department of Radiology, Hangzhou Ninth People's Hospital, Hangzhou, Zhejiang, 310020, China Y. Qian 7900319475328460028610 7900319475328460028610 No Department of Radiology, Xiaoshan District Traditional Chinese Medicine Hospital, Hangzhou, Zhejiang, 311200, China Zh. Gao 7900319475328460028611 7900319475328460028611 No Department of Radiology, Xiaoshan District Traditional Chinese Medicine Hospital, Hangzhou, Zhejiang, 311200, China Zh. Han 7900319475328460028612 7900319475328460028612 No Department of Radiology, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, Zhejiang, 310000, China M. Zhan 7900319475328460028613 7900319475328460028613 No Department of Radiology, Hangzhou Ninth People's Hospital, Hangzhou, Zhejiang, 310020, China Ch. Xu xcf628@163.com 7900319475328460028614 7900319475328460028614 Yes Department of Radiology, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, Zhejiang, 310000, China