en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Scavenger receptor cysteine-rich family member with 4 domains (SSC4D) is aberrantly expressed in gastric cancer (GC) based on bioinformatics analysis. However, its function has not been studied in GC. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods:</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> The relation of SSC4D with GC patient survival and diagnsois was investigated based on bioinformatics analysis and clinical information from forty-seven patients. SSC4D was silenced by shRNAs and the impact of SSC4D silencing on GC cell proliferaton, migration, and invasion was analyzed. Xenograft nude mice were also used to reveal the function of SSC4D on GC carciogenesis at a pre-clinical level. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">The knockdown of SSC4D inhibits GC cell malignacy as well as tumorigenesis. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">SSC4D exerts oncogenic effects on GC cell growth, migration, invasiveness and epithelial cell mesenchymal transition (EMT) and tumor growth.</span></span></span></span></span></span></span></span></span></div> Gastric cancer, SSC4D, biomarker, migration, invasion. 963 970 http://ijrr.com/browse.php?a_code=A-10-1-1264&slc_lang=en&sid=1 J. Zhou 7900319475328460028637 7900319475328460028637 No Department of Gastrointestinal Digestive Center, Haining Traditional Chinese Medicine Hospital, Jiaxing, Zhejiang, 314400, China T. Jiang 7900319475328460028638 7900319475328460028638 No Department of Gastrointestinal Digestive Center, Haining Traditional Chinese Medicine Hospital, Jiaxing, Zhejiang, 314400, China Q. Qi qiqingqing2023@163.com 7900319475328460028639 7900319475328460028639 Yes Department of Pediatric, Haining Traditional Chinese Medicine Hospital, Jiaxing, Zhejiang, 314400, China