en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">Radiation therapy is associated with a risk of long-term adverse effects. Ginger extract has several components that have many biological activities and vitamin c has also been recognized for protection against radiation-induced cell damage. The present study is designed to investigate the possible ameliorating effect of ginger extract and vitamin C on radiation-induced oxidative body damage.&nbsp; Ginger extract and vitamin C were daily given to rats during 14 days before starting irradiation. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Method: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">Rats were exposed to gamma radiation (6 Gray). </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">the result revealed that the levels of lipid peroxidation measured in brain tissues such as malondialdehyde (MDA), acetylcholinesterase (AChE) were significantly increased, while reduced the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) content, dopamine (DA) and serotonin (ST) levels were significantly decreased in the brain homogenate of irradiated rats. Gamma-irradiation (6 Gy) resulted in a significant elevation in inflammatory markers of tumor necrosis factor-alpha (TNF-</span></span></span></span><span lang="el" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:el">&alpha;), </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">interleukin-6 (IL-6), interleukin-12 (IL-12) and C-reactive protein (CRP) compared to the control group. The rats that were administrated combined treatment with ginger extract and vitamin C showed significantly less severe damage and remarkable improvement in all of the last mentioned parameters when compared to irradiated rats. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusions: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">According to the results obtained it could be concluded that a combined treatment with ginger extract by its antioxidant constituents, and vitamin C might be a useful candidate against radiation-induced oxidative stress, enzyme activities in the brain and metabolic disorders without any toxicity.</span></span></span></span></span></span></span></span></span></span></div> Gamma radiation, brain, Ginger extract, vitamin C, oxidative stress, antioxidants. 1027 1035 http://ijrr.com/browse.php?a_code=A-10-1-1272&slc_lang=en&sid=1 D.S. Mansour 7900319475328460028795 7900319475328460028795 No Biological Applications Department, Nuclear Research Center, Atomic Energy Authority, Egypt R.M. Morsi 7900319475328460028796 7900319475328460028796 No Biological Applications Department, Nuclear Research Center, Atomic Energy Authority, Egypt A.M. Mousa amr_halim72@yahoo.com 7900319475328460028797 7900319475328460028797 Yes Biological Applications Department, Nuclear Research Center, Atomic Energy Authority, Egypt