International Journal of Radiation Research

en Two-samples mendelian randomization analysis of the causal relationship between depression intervention and radiotherapy sessions Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Previous research suggests that depression interventions may affect the session of radiotherapy (RT), though the causal relationship remains uncertain. This research seeks to elucidate the cause-and-effect link between treatments for depression and RT sessions through the application of two-sample Mendelian randomization (TSMR) analysis. Materials and Methods: Information on depression treatments and RT sessions was sourced from publicly available genome-wide association studies (GWAS) summary data. Genetic variations known as single nucleotide polymorphisms (SNPs) that are closely linked to depression treatments were chosen as instrumental variables (IVs). Six distinct TSMR techniques were utilized, including MR Egger, weighted median, inverse variance weighted (IVW), weighted mode, IVW with fixed effects, and MR Egger with bootstrap. The causal relationship between depression interventions and RT session was primarily assessed using the P-value from the IVW fixed effects model. Heterogeneity and pleiotropy tests were conducted to validate the findings. Results: Eight sensitive SNPs were identified for the analysis. Both the MR Egger (Q_pval=0.118>0.05) and inverse variance weighted (Q_pval=0.143>0.05) methods indicated low heterogeneity in the MR analysis. The findings remained consistent  through various sensitivity  tests. The IVW fixed effects analysis revealed a significant causal effect between depression intervention and RT session (P=0.016, OR=0.979, 95% CI: 0.961-0.996), indicating a negative causal relationship. Conclusion: Depression intervention appears to be a beneficial factor in reducing RT session, supporting its integration into treatment plans for RT patients to enhance their quality of life.</div> Mendelian randomization analysis, radiotherapy, depression, genome-wide association studies. 521 526 http://ijrr.com/browse.php?a_code=A-10-1-1362&slc_lang=en&sid=1 N. Lei 7900319475328460031332 7900319475328460031332 No Division of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China Z. Li lizhenglys@126.com 7900319475328460031333 7900319475328460031333 Yes Department of Radiation Oncology and Division of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China H. Xu 7900319475328460031334 7900319475328460031334 No Division of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China X. Liu 7900319475328460031335 7900319475328460031335 No Division of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China Y. Zhou 7900319475328460031336 7900319475328460031336 No Division of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China S. Lei 7900319475328460031337 7900319475328460031337 No Division of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China X. Wang 7900319475328460031338 7900319475328460031338 No Division of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China Q. Wang 7900319475328460031339 7900319475328460031339 No Division of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China Y. Li 7900319475328460031340 7900319475328460031340 No Division of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China X. Cai 7900319475328460031341 7900319475328460031341 No Division of Abdominal Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China