en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background:</span></span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">This study focuses on analyzing the effects of three-dimensional conformal radiotherapy (3DCRT) and image-guided radiotherapy (IGRT) on the safety and prognosis of individuals with hepatocellular carcinoma (HCC). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods:</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> Eighty cases of HCC individuals admitted between January 2023 and December 2023 were studied; the control group received IGRT intervention with 34 cases; the research group received 3DCRT intervention with 46 cases. The safety (incidence of grade 1, 2, and 3 hepatic toxic side effects), prognosis, range of lower extremity computed tomography angiography-planned target volume (CTV-PTV) externally, and efficacy of the treatment were comparatively analyzed. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">The data manifested that the incidence of grade 1 toxicity in the research group exceeded that in the control group, but the incidence of grade 3 toxicity in the research group was lower, and the 1-year and 2-year survival rates in the research group were greater. The median survival time in the research group was longer than that in the control group. The range of CTV-PTV exposure in the left and right, head and foot, anterior and posterior aspects was lower than that in the control group. In addition, the CR+PR rate was significantly higher in the research group. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">These outcomes revealed that IGRT is more suitable for HCC patients than 3DCRT, which not only has a certain degree of safety, but also can help to significantly improve the prognosis.</span></span></span></span></span></span></span></span></span></div> Hepatocellular carcinoma, image-guided radiotherapy, three-dimensional conformal radiotherapy, safety, prognosis. 563 567 http://ijrr.com/browse.php?a_code=A-10-1-1368&slc_lang=en&sid=1 F. Xu 7900319475328460031363 7900319475328460031363 No Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China P. Xu ki2233@163.com 7900319475328460031364 7900319475328460031364 Yes Department of Radiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province, China