en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background:</span></span></span></span></span></span> <span lang="en-US" style="language:en-US">Thyroid nodules are common and can be benign or malignant. Ultrasound-guided fine needle aspiration cytology (USG-guided FNAC) is a new method for differentiating these nodules, but previous studies have yet to provide consistent conclusions. The aim of the study was to explore the effectiveness of USG-guided FNAC combined with ultrasonography in diagnosing benign and malignant thyroid nodules. </span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="language:en-US">The study involved 87 patients who underwent thyroid ultrasound and USG-guided FNAC. The results were compared with surgical and pathological findings, and the diagnostic efficiency was analyzed using ROC curves. </span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="language:en-US">Among the 87 thyroid nodules, 22 were malignant, and 53 were benign. USG-guided FNAC alone diagnosed 34 malignant and 58 benign cases, while the combined method diagnosed 25 malignant and 63 benign cases. The ROC curve analysis showed that the combined method had a higher area under the curve (AUC) compared to ultrasound or FNAC alone, indicating better diagnostic accuracy. </span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="language:en-US">Combining USG-guided FNAC with ultrasound improves the sensitivity of preoperative differential diagnosis of benign and malignant thyroid nodules.</span></span></span></span></span></span></span></div> Thyroid nodules, ultrasound-guided FNAC, benign and malignant, diagnostic accuracy, ROC curve analysis. 607 612 http://ijrr.com/browse.php?a_code=A-10-1-1374&slc_lang=en&sid=1 J.F. Liu 7900319475328460031491 7900319475328460031491 No Ultrasound Department, Tongling Municipal Hospital, Tongling, Anhui Province, China J. Qian 7900319475328460031492 7900319475328460031492 No Ultrasound Department, Tongling Municipal Hospital, Tongling, Anhui Province, China J. Ma 7900319475328460031493 7900319475328460031493 No Ultrasound Department, Tongling Municipal Hospital, Tongling, Anhui Province, China H.X. Tang 7900319475328460031494 7900319475328460031494 No Ultrasound Department, Tongling Municipal Hospital, Tongling, Anhui Province, China J.X. Ding 7900319475328460031495 7900319475328460031495 No Ultrasound Department, Tongling Municipal Hospital, Tongling, Anhui Province, China Y.Y. Tong 13965238978@163.com 7900319475328460031496 7900319475328460031496 Yes Ultrasound Department, Tongling Municipal Hospital, Tongling, Anhui Province, China