en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background:</span></span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Our new present study uses biological indices to predict NTCP (normal tissue complications probability) and TCP (tumor control probability) in breast cancer patients undergoing mastectomy planned with MIT (monoisocentric technique) and DIT (dual isocentric technique) in the 3DCRT (three-dimensional conformal radiotherapy). </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">This study involved using DVH (dose-volume histograms) from randomly selected patients to calculate the NTCP and TCP with our in-house program, RADBIOFOR. We focused on specific parameters related to pneumonitis in the lungs, pericarditis in the heart, and tumor control for the targeted area. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">The incidence of clinical symptomatic pneumonitis grade 2 is lower for MIT than DIT, with a mean&nbsp; difference of 6.86%, 1.39% for symptomatic radiation pneumonitis grade 2, 1.17% and 0.82% for radiation pneumonitis grade 2. Both techniques produced comparable results, with MIT showing slightly better control than DIT, resulting in a mean difference of 0.18%. Our study suggests that the mean lung dose significantly affects the incidence of radiation pneumonitis. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">MIT outperforms DIT and offers better lung and heart protection with a lower incidence of radiation complications. Similar local control rates in the chest wall and lymph node region.</span></span></span></span></span></span></span></span></span></div> Monoisocentric technique, dual isocentric technique, TCP, NTCP, pneumonitis, 3DCRT. 691 695 http://ijrr.com/browse.php?a_code=A-10-1-1385&slc_lang=en&sid=1 N. Dahdouh narimane.dahdouh@univ-setif.dz 7900319475328460031806 7900319475328460031806 Yes Department of Laboratory of Optoelectronics and Devices, Physics Department, Faculty of Sciences, UFAS1; Algeria Z. Chaoui 7900319475328460031807 7900319475328460031807 No Department of Laboratory of Optoelectronics and Devices, Physics Department, Faculty of Sciences, UFAS1; Algeria S. Khoudri 7900319475328460031808 7900319475328460031808 No Cancer Center of Setif, Algeria