International Journal of Radiation Research

en Correlation between clinical, CT features and EGFR gene in minimally invasive adenocarcinoma Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: To analyze the correlation between epidermal growth factor receptor (EGFR) gene mutations and clinical as well as computed tomography (CT) signs in minimally invasive adenocarcinoma (MIA). Materials and Methods: A total of 118 patients with MIA treated at the Department of Thoracic Surgery, Tangshan Gongren Hospital, from December 2018 to December 2021 were included in this study. Patients were categorized into two groups based on their Epidermal Growth Factor Receptor（EGFR）mutation status: a mutation group and a wild-type group. Differences in clinical and CT features between the two groups were recorded and statistically analyzed. Results: Among the 118 patients, 69 were in the mutation group, while 49 were in the wild-type group. No significant differences were observed in gender, smoking history, age, mean nodule diameter, peripheral emphysema, air bronchogram, lobulation sign, pleural indentation sign, morphology, tumor-lung interface, peripheral fibrosis, and density between the two groups (P > 0.05). However, significant differences were noted in the spiculation sign, vacuole sign, and vascular convergence sign between the groups (P < 0.05). Logistic regression analysis identified the vacuole sign with an odds ratio (OR) of 0.410 (P > 0.05) and the spiculation sign and vascular convergence sign with ORs of 1.498 and 2.262, respectively (P < 0.05), as independent risk factors for predicting EGFR mutations. The areas under the ROC curves (AUC) for the spiculation sign and vascular convergence sign were 0.634 and 0.735, respectively, in distinguishing EGFR gene mutations in MIA.</div> Lung adenocarcinoma, CT signs, epidermal growth factor receptor, tomography, X-ray computed. 43 48 http://ijrr.com/browse.php?a_code=A-10-1-1453&slc_lang=en&sid=1 L.P. Zhou 7900319475328460032719 7900319475328460032719 No Department of Function, The Fifth Hospital of Tangshan (CT/DR Room), Tangshan, China L.M. Chang 240612799@qq.com 7900319475328460032720 7900319475328460032720 Yes Department of Medical Imaging, Tangshan Gongren Hospital, Tangshan, China H. Zhao 7900319475328460032721 7900319475328460032721 No Department of Medical Imaging, Tangshan Gongren Hospital, Tangshan, China X.Y. Yang 7900319475328460032722 7900319475328460032722 No Department of Medical Imaging, Tangshan Gongren Hospital, Tangshan, China L.L. Shi 7900319475328460032723 7900319475328460032723 No Department of Radiology, Tangshan Maternal and Child Health Hospital, Tangshan, China