International Journal of Radiation Research

en Efficacy of tislelizumab combined with gemcitabine and resulting changes in CT imaging for advanced non-small cell lung cancer Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: The purposes of this study were to evaluated the efficacy and changes in computed tomography (CT) imaging associated with tislelizumab combined with gemcitabine for advanced non-small cell lung cancer (NSCLC). Material and Methods: This study examined 122 patients with advanced NSCLC who were treated at our hospital between January 2021 and October 2023. Subjects were categorized into the control group (gemcitabine monotherapy) and study group (tislelizumab + gemcitabine), with 61 patients in each group. Clinical efficacy, CT imaging changes (maximum lesion diameter, CT value, short diameter of metastatic lymph nodes), serum tumor markers (CA125, CEA, NSE), quality of life (FACT-L), drug safety, and survival outcomes were compared between groups. Results: The study group showed higher rates of objective remission (42.62%) and clinical control (86.89%) compared to the control group (18.03% and 62.30%, respectively, x2=8.728, 9.731, P<0.05). CT parameters (maximum diameter, CT value, and short diameter of metastatic lymph nodes) were remarkably shorter in the study group (P<0.05). Serum CA125, CEA, and NSE levels were decreased in the study group, and their FACT-L score was higher (P<0.05). No remarkable discrepancy was found in complication rates. At the one-year follow-up, the survival rate was 70.49% in the study group and 44.26% in the control group (x2=13.571, P<0.05). Conclusion: Tislelizumab combined with gemcitabine improves short-term efficacy, reduces serum tumor markers, enhances life quality, increases survival rates in advanced NSCLC patients, and has a good safety profile.</div> <div style="text-align: justify;"></div> Tislelizumab, gemcitabine, lung neoplasms, non-small-cell, combined modality therapy. 55 62 http://ijrr.com/browse.php?a_code=A-10-1-1455&slc_lang=en&sid=1 Z. Li 7900319475328460032730 7900319475328460032730 No Radiology Department, First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou Province, China M. Pu 7900319475328460032731 7900319475328460032731 No Radiology Department, First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou Province, China R. Huang 7900319475328460032732 7900319475328460032732 No Radiology Department, First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou Province, China P. Zhou 7900319475328460032733 7900319475328460032733 No Radiology Department, First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou Province, China T. Zhang 7900319475328460032734 7900319475328460032734 No Radiology Department, First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou Province, China Y. Zhang zhangyusui3785@hotmail.com 7900319475328460032735 7900319475328460032735 No Radiology Department, First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou Province, China