en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background:</span></span></span></span></span></span> <span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">To observe the effect of quantitative parameters of intravoxel incoherent motion-diffusion weighted imaging (IVIM-DWI) in the evaluation of transcatheter arterial chemoembolization (TACE) combined with 3-dimensional conformal radiation therapy (3D-CRT) treatment effect. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Materials and Methods: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">Research subjects were selected from 80 cases of patients with primary liver cancer (PLC) from May 2021 to October 2022. According to the judgment criteria of treatment effect of solid tumors, the patients were divided into complete remission (CR)/partial remission (PR) group (n=37) and stable disease (SD)/progressive disease (PD) group (n=43) after TACE combined with 3D-CRT treatment. The quantitative parameters of IVIM-DWI [F value, D* value, D value and apparent diffusion coefficient (ADC) value] in the two groups were compared. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Results: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">The value of D*, F, D and ADC of IVIM-DWI quantitative parameters in the SD/PD group were all higher‌ (P<0.05). The receiver operating characteristic (ROC) curve indicated that the area under curve (AUC) of the value of D*, F, D and ADC in IVIM-DWI quantitative parameters of patients with PLC to predict the effect of TACE combined with 3D-CRT in patients were 0.827, 0.777, 0.827, 0.863 and 0.923, and the AUC of the combination prediction was the largest. The sensitivity and specificity of combined prediction were 92.3% and 81.1% (Youden index 0.896), respectively. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Conclusion: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">The value of D*, F, D and ADC in IVIM-DWI quantitative parameters are feasible to evaluate the treatment effect of TACE combined with 3D-CRT in patients with PLC.</span></span></span></span></span></span></span></span></span></span></div> Hepatocellular carcinomas, multiparametric magnetic resonance imaging, radiotherapy, chemoembolization therapeutic, ROC Curve. 97 102 http://ijrr.com/browse.php?a_code=A-10-1-1461&slc_lang=en&sid=1 Z. Wu 7900319475328460032814 7900319475328460032814 No Department of Radiology, The Second People's Hospital of Hunan Province, Changsha, Hunan, China Y. Pang 7900319475328460032815 7900319475328460032815 No Department of Radiology, The Second People's Hospital of Hunan Province, Changsha, Hunan, China J. Wang 7900319475328460032816 7900319475328460032816 No Department of Radiology, The Second People's Hospital of Hunan Province, Changsha, Hunan, China P. Gao 7900319475328460032817 7900319475328460032817 No Department of Interventional Medicine, The Second People's Hospital of Hunan Province, Changsha, Hunan, China W. Yin 7900319475328460032818 7900319475328460032818 No Department of Oncology, The Second People's Hospital of Hunan Province, Changsha, Hunan, China Y. Xia yizherenx5555@163.com 7900319475328460032819 7900319475328460032819 Yes Medical Imaging Center, Jiujiang NO.1 People's Hospital, Jiujiang, Jiangxi, China