en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">We aimed to analyze the significance of multi-slice spiral computed tomography (CT) combined with carcinoembryonic antigen (CEA) and Wnt pathway inhibitor (DKK1) for the diagnosis of early-stage lung carcinoma. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Materials and Methods:</span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB"> Subjects (102 in total) were selected from patients with suspected early-stage lung carcinoma receiving treatment in the hospital. Multi-slice spiral CT was performed on all subjects, CEA and DKK1 levels in the serum were detected, and the diagnostic efficiency of multi-slice spiral CT for early-stage lung cancer was analyzed. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Results: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">The sensitivity of 94.25% (82/87), Youden index of 0.743, specificity of 80.00% (12/15), accuracy of 92.16% (94/102), positive diagnostic value of 96.47% (82/85), and negative diagnostic value of 70.59% (12/17) were obtained for multi-slice spiral CT in diagnosing early-stage lung cancer. As revealed by receiver operating characteristic curve analysis results, multi-slice spiral CT parameters combined with CEA and DKK1 had an area under the curve of 0.954, sensitivity of 95.22% and specificity of 86.17% in the diagnosis of early-stage lung carcinoma, significantly superior to multi-slice spiral CT parameters, CEA or DKK1 alone (P<0.05). </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Conclusion: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">The combination of CEA and DKK1 with multi-slice spiral CT can improve the diagnostic efficiency for early-stage lung cancer.</span></span></span></span></span></span></span></span></span></span></div> Carcinoembryonic antigen, diagnosis, lung neoplasms, CT. 103 108 http://ijrr.com/browse.php?a_code=A-10-1-1462&slc_lang=en&sid=1 X. Zhang 7900319475328460032854 7900319475328460032854 Yes Department of Respiratory and Critical Care Medicine, The official name of our hospital has been changed into 301 Hospital, Beijing, China X. Wu 7900319475328460032855 7900319475328460032855 No Department of Respiratory and Critical Care Medicine, Jiangxi Provincial People's Hospital (The First Affiliated Hospital of Nanchang University), Nanchang, Jiangxi Province, China G. Wang becky.shaw133049@yahoo.com 7900319475328460032856 7900319475328460032856 No Department of Radiology, Zhejiang Lishui People’s Hospital, Lishui, Zhejiang Province, China