International Journal of Radiation Research

en Efficacy and safety of ultrasound-guided microwave ablation therapy for benign and malignant thyroid nodules of different sizes based on real-world evidence Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Benign and malignant thyroid nodules (BMTDs) often show lymph-node metastasis in the neck and impose great physical and psychological burdens. Therefore, early diagnosis and treatment BMTD are essential. The objective of this study was to analyze the effectiveness and safety of ultrasound-guided microwave ablation therapy for BMTDs of different sizes. Materials and Methods: The study examined 180 patients with solitary BMTD from Shijiazhuang People’s Hospital between June 2022 and June 2024. Patients with BMTD diameter larger than 1 cm were assigned to group A (60 patients), and those with diameters of 0.5–1 cm were assigned to group B (60 patients). Group C comprised those with BMTD diameters smaller than <0.5 cm (60 patients). All patients were treated with conventional thyroid ultrasound, ultrasonography, and ultrasound-guided microwave ablation. The primary assessments were the change in transverse and longitudinal diameters of the thyroid nodules, volume reduction rate (VRR), and cure rate at months 1, 3, 6, and 9 post-treatment. The secondary outcomes were quality-of-life scores, incidence of adverse effects, complications, and recurrence rates. Results: After treatment, all indicators improved in all groups. Group C had greater improvements in nodule diameter, VRR, cure rate, cosmetic score, adverse reactions, and complications than group A and group B. Thyroid biochemical indicators showed greater improvement in groups B and C than group A (P<0.05). No groups showed any recurrence (P>0.05). Conclusion: Ultrasound-guided microwave ablation can treat BMTD and is particularly suitable for solitary thyroid nodules with diameter <0.5 cm, which showed the highest cure rate.</div> Microwave Ablation, ultrasonography, thyroid nodule, nodule size, therapeutic efficacy. 143 150 http://ijrr.com/browse.php?a_code=A-10-1-1468&slc_lang=en&sid=1 L. Zhang 7900319475328460032885 7900319475328460032885 No Department of Clinical Nutrition and Metabolism, Shijiazhuang People's Hospital, Shijiazhuang, Hebei, China Y. Liu 7900319475328460032886 7900319475328460032886 No Department of Endocrinology and Metabolism, Shijiazhuang People's Hospital Fanxi Road Campus, Shijiazhuang, Hebei, China P. Zhang 7900319475328460032887 7900319475328460032887 No Department of Clinical Nutrition and Metabolism, Shijiazhuang People's Hospital, Shijiazhuang, Hebei, China Y. Zhang 7900319475328460032888 7900319475328460032888 No School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, UK M. Xie 7900319475328460032889 7900319475328460032889 No Department of Plastic and Cosmetic Surgery, Shijiazhuang People's Hospital Fanxi Road Campus, Shijiazhuang, Hebei, China X. Zhang 7900319475328460032890 7900319475328460032890 No Department of Clinical Nutrition and Metabolism, Shijiazhuang People's Hospital, Shijiazhuang, Hebei, China H. Li 7900319475328460032891 7900319475328460032891 No Department of Endocrinology and Metabolism, Shijiazhuang People's Hospital Fanxi Road Campus, Shijiazhuang, Hebei, China Y. Duan Duanyulong191960@126.com 7900319475328460032892 7900319475328460032892 Yes Department of Medical Imaging, Henan Armed Police Corps Hospital, Zhengzhou, Henan, China