International Journal of Radiation Research

en Relationship between peripheral-blood immuno-inflammatory markers, radiotherapy efficacy, and 1-year overall survival rate among patients with stage III non-small cell lung cancer Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Locally advanced non-small cell lung cancer (NSCLC) is often associated with unfavorable clinical outcomes. This study aims to examine the association between peripheral immuno-inflammatory biomarkers, the effectiveness of radiotherapy, and 1-year survival rates in stage III NSCLC. Materials and Methods: This study reviewed 180 stage III NSCLC patients treated with radical radiotherapy from 2020 to 2024. Pretreatment neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), and lymphocyte-to-monocyte ratio (LMR) levels were measured and compared with healthy controls. Biomarker differences were analyzed across clinical subgroups and between radiotherapy response groups. Using median values as cutoffs, one-year survival data were assessed, with Cox regression determining prognostic factors. Results: Patients with NSCLC had significantly higher NLR, PLR, and SII and lower LMR than the control group (P<0.05). The good-response group had lower NLR, PLR, and SII and higher LMR (P<0.05). Higher NLR, PLR, and SII were associated with worse 1-year survival, while higher LMR predicted better outcomes (P<0.05). Cox analysis confirmed that all four markers were independent prognostic factors (P<0.05). Conclusion: The peripheral blood markers NLR, PLR, SII, and LMR are closely associated with radiotherapy efficacy and 1-year survival in stage III NSCLC.</div> Carcinoma, non-small-cell lung, inflammatory markers, radiotherapy, survival rate, stage III neoplasms. 151 157 http://ijrr.com/browse.php?a_code=A-10-1-1469&slc_lang=en&sid=1 T. Li Li ty13841402@hotmail.com 7900319475328460032894 7900319475328460032894 Yes Department of Pulmonary and Critical Care Medicine, General Hospital of Benxi Iron, Liaoning Province, China B. Han 7900319475328460032895 7900319475328460032895 No Department of Pulmonary and Critical Care Medicine, General Hospital of Benxi Iron, Liaoning Province, China Q. Dong 7900319475328460032896 7900319475328460032896 No Department of Pulmonary and Critical Care Medicine, General Hospital of Benxi Iron, Liaoning Province, China D. Ji 7900319475328460032897 7900319475328460032897 No Department of Pulmonary and Critical Care Medicine, General Hospital of Benxi Iron, Liaoning Province, China