en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background:</span></span></span></span></span></span> <span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">To delve into the association between preoperative immune-related markers and lymphovascular space invasion (LVSI) in patients with endometrial cancer (EC). </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Materials and Methods: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">According to the 7:3 allocation, 411 EC patients were analyzed. Clinical and pathological data were collected, and imaging histologic features were extracted from contrast-enhanced T1-weighted imaging (CE-T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and apparent diffusion coefficient (ADC) maps, the related factors affecting LVSI were analyzed. Subsequently, a backward step-wise selection approach was adopted to select the most relevant variables for incorporation into the nomogram. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Results: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">In the training cohort, independent predictors for LVSI were identified as systemic immune-inflammation index (SII), depth of myometrial invasion (MI), and carbohydrate antigen 125 (CA125) levels. The nomogram was used to predict the probability of LVSI, and the area under the ROC curve was 0.7813. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Conclusion: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">LVSI positivity in EC patients is strongly associated with elevated SII, MI&ge;1/2, and high CA125 levels. The SII-based nomogram provides a reliable tool for predicting LVSI status in EC patients.</span></span></span></span></span></span></span></span></span></span></div> Endometrial cancer, nomogram, magnetic resonance imaging, diagnosis, risk modeling. 167 171 http://ijrr.com/browse.php?a_code=A-10-1-1471&slc_lang=en&sid=1 Y. Li 7900319475328460032900 7900319475328460032900 No Department 3 of Gynecological Oncology, Jilin Cancer Hospital, Changchun, Jilin, China Z. Xie 7900319475328460032901 7900319475328460032901 No Department 3 of Gynecological Oncology, Jilin Cancer Hospital, Changchun, Jilin, China J. Liu 7900319475328460032902 7900319475328460032902 No Department 3 of Gynecological Oncology, Jilin Cancer Hospital, Changchun, Jilin, China J. Piao 13578945886@163.com 7900319475328460032903 7900319475328460032903 Yes Department 3 of Gynecological Oncology, Jilin Cancer Hospital, Changchun, Jilin, China