en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">To observe the expression of serum vascular endothelial growth factor receptor-3 (VEGFR-3) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) quantitative parameters in patients with lung adenocarcinoma (AOL) mediastinal lymph node metastasis (MLNM), and analyze the relationship between the above parameter and MLNM of AOL. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Materials and Methods: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">One hundred patients with AOL, they were divided into MLNM group and non-MLNM group. Two groups were compared in the DCE-MRI quantitative parameters [Rate constant (Kep), volume transfer constant (Ktrans), extravascular extracellular volume fraction (Ve), and apparent diffusion coefficient (ADC)] and serum VEGFR-3 expression, and the relationship between the above index parameters and MLNM in patients with AOL was analyzed. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Results: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">Compared with the non-MLNM group, the Ktrans, Kep, Ve value and expression of serum VEGFR-3 in the MLNM group were higher, the ADC value was lower (P<0.05). Logistics regression analysis showed that preoperative fasting serum VEGFR-3 expression was related to MLNM in patients with AOL, and high VEGFR-3 expression might be a risk factor for MLNM in patients with AOL (OR>1, P<0.05). The ROC curve showed that the AUC of VEGFR-3 and DCE-MRI quantitative parameters to predict MLNM in patients with AOL was greater than 0.70. </span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-GB">Conclusion: </span></span></span></span></span></span><span lang="en-GB" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-GB">The DCE-MRI quantitative parameters combined with serum VEGFR-3 expression has a certain value in the preoperative assessment of MLNM in patients with AOL.</span></span></span></span></span></span></span></span></span></span></div> Adenocarcinoma of lung, magnetic resonance imaging, vascular endothelial growth factor receptor-3, lymphatic metastasis, diagnosis. 215 219 http://ijrr.com/browse.php?a_code=A-10-1-1478&slc_lang=en&sid=1 J. Yang 7900319475328460032958 7900319475328460032958 No Department of Radiology, Huanggang Central Hospital, Huanggang, Hubei, China P. Guo 7900319475328460032959 7900319475328460032959 No Department of Laboratory Medicine, Huanggang Central Hospital, Huanggang, Hubei, China D. Zhou 7900319475328460032960 7900319475328460032960 No Department of Radiology, Huanggang Central Hospital, Huanggang, Hubei, China L. Ding 7900319475328460032961 7900319475328460032961 No Department of Radiology, Huanggang Central Hospital, Huanggang, Hubei, China P. Jiang hgszxyycgzs201106@163.com 7900319475328460032962 7900319475328460032962 Yes Department of Radiology, Huanggang Central Hospital, Huanggang, Hubei, China