International Journal of Radiation Research

en CT-based evaluation of negative pressure sinus therapy in upper airway cough syndrome: Insights into airway remodeling and tumor detection Radiation Biology Radiation Biology گزارش کوتاه Short Report <div style="text-align: justify;">Background: Upper airway cough syndrome (UACS) is a common condition marked by chronic cough, nasal congestion, and throat irritation. Standard treatments-including antihistamines, decongestants, and corticosteroids-often yield limited relief. Sinus Negative Pressure Exchange (SNPE) technology has emerged as a novel approach that may enhance sinonasal drainage and mucociliary function. CT imaging provides structural insights and may aid in the detection of sinus tumors. Materials and Methods: This retrospective study evaluated patients with UACS treated using SNPE technology. Symptom severity-cough frequency, nasal blockage, and throat discomfort-was assessed before and after treatment. CT scans were used to assess anatomical changes and to identify any incidental sinus tumors. Logistic regression was used to explore factors associated with clinical response. Results: Patients undergoing SNPE therapy showed significant improvement in cough and nasal congestion. CT scans demonstrated better sinus aeration and drainage post-treatment, supporting the physiological benefits of SNPE. In several cases, clearer imaging enabled incidental detection of sinus tumors, suggesting a potential diagnostic advantage. Regression analysis confirmed a strong association between SNPE use and symptom relief, influenced by baseline severity and comorbidities. Conclusion: SNPE technology shows promise as a dual-purpose intervention for UACS—offering both symptomatic relief and improved radiologic visualization. These findings support SNPE's potential role in managing UACS and facilitating incidental sinus tumor detection. Larger prospective studies are recommended to confirm these outcomes and assess broader clinical implications.</div> Cough, upper respiratory tract diseases, negative-pressure therapy, CT imaging, sinus neoplasms, treatment outcomes. 277 282 http://ijrr.com/browse.php?a_code=A-10-1-1487&slc_lang=en&sid=1 S. Zhang 7900319475328460033025 7900319475328460033025 No Department of Otolaryngology, Sanmen People's Hospital, Taizhou City, Zhejiang Province, China M. Xu 7900319475328460033026 7900319475328460033026 No Department of Otolaryngology, Sanmen People's Hospital, Taizhou City, Zhejiang Province, China X. Shen 7900319475328460033027 7900319475328460033027 No Department of Otolaryngology, Sanmen People's Hospital, Taizhou City, Zhejiang Province, China J. Ke kejuying@zjsmyy.com 7900319475328460033028 7900319475328460033028 Yes Department of Otolaryngology, Sanmen People's Hospital, Taizhou City, Zhejiang Province, China