en jalali 1401 7 1 gregorian 2022 10 1 20 4 online 1 fulltext

en Radiation-induced brain injury (RIBI) is a common complication in patients with head and neck tumors. RIBI usually occurs six months to three years after therapy and is often accompanied by cognitive dysfunction, epilepsy, and other neurological dysfunctions. In severe cases, RIBI can cause a wide range of cerebral edema and herniation. A systematic search was conducted through PubMed/Medline, EMBASE, and Cochrane library databases and articles with the keywords radiation-induced brain injury, pathogenesis and protective agents were collected. The commonly known pathogenesis of RIBI includes vascular injury, immune-inflammatory response, glial cell damage, and neuronal damage. Therapeutic agents, hyperbaric oxygen, surgery, and stem cells transplantation are the most common treatment for RIBI. Tamoxifen, curcumin, and quercetin can prevent glial cell activation, proliferation, and oxidative stress caused by irradiation. Over recent years, the RIBI remission rate has gradually increased; however, there are still no effective prevention and treatment methods. This review summarized recent progress in the treatment for RIBI, as well as the pathogenesis of RIBI, including vascular injury, glial cell injury, immune-inflammatory response, and neuronal damage. Radiation-induced brain injury (RIBI), conventional medicine, pathogenesis, hyperbaric oxygen (HBO), protective agents. 727 736 http://ijrr.com/browse.php?a_code=A-10-1-971&slc_lang=en&sid=1 2022/10/22 1401/7/30 2022/10/18 1401/7/26 Y. Zhang Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China 00319475328460022521 00319475328460022521 No G. Ou Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China 00319475328460022522 00319475328460022522 No Q. Li Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China 00319475328460022523 00319475328460022523 No S. Ma School of Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China mashan76@sina.com 00319475328460022524 00319475328460022524 Yes L. Du Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China 00319475328460022525 00319475328460022525 No

en Background: To investigate whether features of 5-mm peritumoral regions could significantly improve the predictive efficacy of a radiomics model based on solid pulmonary tumors at distinguishing lung adenocarcinoma(LAC) from granuloma(GR). Materials and Methods: We retrospectively evaluated 167 lung tumors pathologically proven to be LAC (96) or GR (71) and divided them into training group (116) and testing (51) group. We delineated each tumor with three different measures using the tumor and its 5-mm peritumoral region. Then, we extracted 465 features from each volume of interest(VOI) and chose the optimal features to build the diagnostic models. We built four different models using different methods. Finally, we compared the performance of the four models in the test set. Results: The area under the curve(AUC) of each model in the test group was 0.765 (95% confidence interval(CI): 0.620–0.909), 0.797 (95%CI: 0.670–0.924), and 0.784 (95%CI: 0.647–0.920), respectively. Results of the DeLong test showed that the differences between model 2, model 3, and model 1 were not significant. Results of net reclassification improvement(NRI) showed that model 2 and model 3 had better differential diagnostic efficacy than model 1, with accuracies(ACCs) of 0.784, 0.745, and 0.686, respectively, but the differences were not significant (P>0.05). Moreover, the nomogram had good diagnostic and predictive abilities, with an AUC of 0.848 (95%CI: 0.736–0.961) and an ACC of 0.804. Conclusions: Features of 5-mm peritumoral regions improved the predictive ability of the radiomics model based on the solid pulmonary tumor, but the difference was not significant. lung adenocarcinomas, granulomas, radiomics, nomogram, machine learning. 737 745 http://ijrr.com/browse.php?a_code=A-10-1-972&slc_lang=en&sid=1 2022/10/222022/10/22 1401/7/30 2022/10/182022/10/18 1401/7/26 Y. Geng Department of Radiology, The fourth Affiliated Hospital of China Medical University, Shengyang, China 00319475328460022527 00319475328460022527 No L. Sun Department of Radiology, The fourth Affiliated Hospital of China Medical University, Shengyang, China 1403952319@qq.com 00319475328460022528 00319475328460022528 Yes M. Sun Department of Radiology, The fourth Affiliated Hospital of China Medical University, Shengyang, China 00319475328460022529 00319475328460022529 No Z. Zhang Department of Radiology, The fourth Affiliated Hospital of China Medical University, Shengyang, China 00319475328460022530 00319475328460022530 No J. Liu Department of Radiology, The fourth Affiliated Hospital of China Medical University, Shengyang, China 00319475328460022531 00319475328460022531 No

en Background: There is an increase in pediatric Computed Tomography (CT) imaging with advancement in technology but CT radiation dose produces significant adverse effects. The objective of this experimental phantom study is to develop an age-based low-dose pediatric CT head protocol. Materials and Methods: Polymethyl methacrylate (PMMA) pediatric head mimicking phantom scanning was performed on a CT scanner using various combinations of tube voltage (kV) and product of tube current and exposure time (mAs) setting. Images were reconstructed by iterative reconstruction iDose4 level 1-5.  Quantitative assessment of image quality (IQ) was done by calculating Signal to Noise Ratio (SNR), Contrast to Noise Ratio (CNR), and Image Noise (IN). Radiation dose indices (RDI) were measured by recording Volumetric CT Dose Index (CTDIv) and Dose length product (DLP). Figure of Merit (FOM) was calculated to study overall effects between IQ and RDI. IQ and RDI obtained using different exposure settings were compared. Result: Optimized age-based low-dose protocols were developed based on IQ analysis and RDI. For pediatric CT head, with age less than one year kV and mAs of 80 and 150 and for one–five years age kV and mAs of 100 and 200 with iDose4 level-3 was found to be optimum low dose protocol. Conclusion: The experimental phantom study concluded that with use of low kVp and mAs, radiation dose was reduced to 62% for less than 1-year age group and 51% for 1-5 year age group and also with use of iterative reconstruction technique iDose4 level-3 diagnostic image quality was maintained. Computed tomography, pediatric population, radiation dose, dose optimization, CT image quality. 747 751 http://ijrr.com/browse.php?a_code=A-10-1-973&slc_lang=en&sid=1 2022/10/222022/10/222022/10/22 1401/7/30 2022/10/182022/10/182022/10/18 1401/7/26 Priyanka Department of Medical Imaging Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India 00319475328460022533 00319475328460022533 No R. Kadavigere Department of Radiodiagnosis and Imaging, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India rajarad@gmail.com 00319475328460022534 00319475328460022534 Yes S. Sukumar Department of Medical Imaging Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India 00319475328460022535 00319475328460022535 No

other Background: Electromagnetic fields may primarily affect cognitive functions. It has not been elucidated how electromagnetic radiation affects the brain, particularly in the young age group. We aimed to examine the cognitive function, expression of N-methyl-D-aspartate receptors (NMDA), and EEG alterations in weaned rats exposed to a 2.45 GHz electromagnetic field. Materials and Methods: Twenty-one weaned (21 days old) male Wistar Albino rats were divided into two groups as experimental group (n=12) and control group (n=9). Animals in the experimental group were exposed to a 2.45 GHz electromagnetic field for one hour a day for more than 28 days. At the end of this period, rats were subjected to training and learning test using Morris Water Maze. After obtaining EEG records, hippocampi were removed. 2A and 2B subunits of NMDA receptors were studied in hippocampal homogenates using the Western Blot method. Results: There were no statistically significant differences between the two groups in measures of latency to target quadrant, time spent in the target quadrant, and average swim speed as compared in Morris water maze. However, the time to arrive at the visible platform was significantly longer in experimental animals. There were no statistically significant differences in expression of 2A and 2B subunits of NMDA receptors between the two groups. Evaluation of EEG records revealed that spike frequency was significantly higher and time to first spike was significantly shorter in the experimental group. Conclusion: These results indicated that a 2.45 GHz electromagnetic field might negatively affect EEG, motivation, and attention, particularly in the young age group. EEG, electromagnetic field, NMDA, Water Maze memory test, weaned rat. 753 760 http://ijrr.com/browse.php?a_code=A-10-1-974&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/22 1401/7/30 2022/10/182022/10/182022/10/182022/10/18 1401/7/26 H. Yucel Manisa City Hospital, Pediatrics, Manisa, Turky 00319475328460022537 00319475328460022537 No N.O. Dundar Izmir Katip Çelebi University, Pediatric Neurology, Izmir, Turkey 00319475328460022538 00319475328460022538 Yes D.K. Doguc Suleyman Demirel University, Biochemistry, Isparta, Turkey 00319475328460022539 00319475328460022539 No C. Uguz Yozgat Bozok University, Biophysics, Yozgat, Turkey 00319475328460022540 00319475328460022540 No O. Celik Demirel University, Biophysics, Isparta, Turkey 00319475328460022541 00319475328460022541 No F. Tutku Aksoy Altinbas University, Biochemistry, Istanbul, Turkey 00319475328460022542 00319475328460022542 No M. Nazıroglu Suleyman Demirel University, Biochemistry, Isparta, Turkey 00319475328460022543 00319475328460022543 No S. Comlekci Suleyman Demirel University, Electronic Engineering, Communication Engineering for Exposure System and Dosimetric Design, Isparta, Turkey 00319475328460022544 00319475328460022544 No B. Dundar Izmir Katip Celebi University, Pediatric Endocrinology, Izmir, Turkey 00319475328460022545 00319475328460022545 No

en Background: Breast cancer (BC) is a global threat to women’s health. Volumetric intensity modulated arc therapy (VMAT) is effective for the local control of BC. This study evaluated the pulmonary and cardiac radiotherapeutic dosage to provide information for estimating normal tissue complication probability (NTCP) once malignant tumors appear in patients’ left and right breasts. Materials and Methods: We conducted a retrospective analysis of VMAT regimen of 40 patients with BC, among whom 20 patients (group 1) were diagnosed with right BC and 20 patients (group 2) with left BC. The pulmonary and cardiac dose volume histogram (DVH) parameters were acquired and compared between patients with left and right BC treated with VMAT. Results: Generally, the pulmonary and cardiac dosages in patients with right BC were larger than in those with left BC. For the lung, the V20 and V5 of right BC patients were significantly higher, relative to the left BC patients (P<0.05). For the heart, the V5 and V10 of right BC patients were significantly lower, compared to left BC patients, with differences of up to 20% and 10%, respectively (both P<0.05). V20, V30, and V40 as low as zero were observed for right BC patients. Conclusions: When treating left BC, image guidance and respiratory management techniques should be applied to limit radiotherapy complications that occur in the heart because of patient positioning and respiratory movement.     Left breast cancer, right breast cancer, VMAT, heart dose, lung dose. 761 765 http://ijrr.com/browse.php?a_code=A-10-1-975&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/22 1401/7/30 2022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 H. Zhang Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China yinhongtao1982@outlook.com 00319475328460022547 00319475328460022547 No H. Yin Department of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin, China wenchengshao@outlook.com 00319475328460022548 00319475328460022548 No W. Shao Department of Radiation Physics, Harbin Medical University Cancer Hospital, Harbin, China 00319475328460022549 00319475328460022549 No

en Background: Radiograph of hand and wrist has been widely used in children's bone age assessment (BAA). However, ionizing radiation may be harmful for children in the future. Therefore, alternative methods have been attempted for the evaluation of children's bone age. Here, we reported an automated volume scanner (AVS) in assessing the biological age of children in comparison with X-ray radiograph as the gold standard. Material and Methods: Total 22 children (13 male and 9 female) with short stature or precocious puberty were enrolled into this study. Their chronological age ranged from 4 to 14 years old. The children's left hand-wrist was scanned with the AVS by putting them into a water sink containing tape water. Coronal images of the left hand-wrist were reconstructed and compared with X-ray images. Results: The number of patients whose hand-wrist bones (except for the first metacarpal sesamoid bone and the secondary ossification center of the first metacarpal bone) identified by AVS image was not significantly different from that by X-ray image. In addition, the total number of observed bones in each patient were not significantly different between the two methods. The concordance rate (percentage of patients whose hand-wrist bone presented in both AVS image and X-ray image) was high and the inter-observer variance of BA was small. Conclusions: The AVS method was highly correlated with the standard radiograph for children's bone age assessment with small inter-observer variability. This novel AVS method could be an alternative method in clinical practice for bone age assessment with higher safety and reliability. radioactive automated volume scanner, bone age assessment, chronological age. 767 772 http://ijrr.com/browse.php?a_code=A-10-1-976&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/22 1401/7/30 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 J. Shi Department of Imaging Diagnosis Center, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China 00319475328460022551 00319475328460022551 No Y. Chen Department of Endocrinology and Genetic Diseases, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China 00319475328460022552 00319475328460022552 No L. Yang Department of Imaging Diagnosis Center, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China 00319475328460022553 00319475328460022553 No Z. Ni Ultrasound Department, Siemens Healthineers Ltd. China 00319475328460022554 00319475328460022554 No J. Du Department of Imaging Diagnosis Center, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China duizhi0360603636@163.com 00319475328460022555 00319475328460022555 Yes Q. Wang Department of Imaging Diagnosis Center, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China wfv313@163.com 00319475328460022556 00319475328460022556 No

en Natural radioactivity, radiation exposure, Gold mine, radionuclides, effective dose. 773 777 http://ijrr.com/browse.php?a_code=A-10-1-977&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/22 1401/7/30 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 D. Kolkoma Department of Applied Physics, PNG University of Technology, Papua New Guinea 00319475328460022558 00319475328460022558 No F. Pereira Department of Applied Physics, PNG University of Technology, Papua New Guinea 00319475328460022559 00319475328460022559 No P.J. Jojo Department of Applied Physics, PNG University of Technology, Papua New Guinea jojopanakal@gmail.com 00319475328460022560 00319475328460022560 No

en Background: This study was designed to evaluate the matching percentage among findings of the ultrasound scans (USS) to the magnetic resonance imaging (MRI) in women with fibroids. Materials and Methods: This descriptive, retrospective study was conducted from January 2016 to December 2018. This study includes 205 female patients referred from the Gynaecological Department to the Radiological Department in the Bahrain Defense Force Hospital for MRI and USS for fibroid evaluation. The data collected included their age, parity, and nationality. The StatsDirect software was used to analyze the fibroids according to the site, size, type, and number. Results: The findings of USS matched the MRI in the posterior fibroid sites in 52.5% of cases, followed by anterior (38.1%) and fundal (21.8%). For fibroid size, USS matched MRI findings in 83.3% for fibroids between >5 to ≤10 cm, 78.3% for fibroids between >2 to ≤5 cm, and 36.8% for fibroids sized ≤2 cm. Fibroids more than 10 cm in size were in agreement for 33.33% of fibroids. Submucosal fibroids matched in just 29.4% of cases, but for the subserosal fibroids, it was 44.8%. The matching score for more than four fibroids was 61.8%, followed by single fibroids (54.8%) and two fibroids (34.8%). Conclusions: Results of USS and MRI were reasonably correlated in terms of fibroid location and size. USS diagnosis of posterior wall and fibroids of size less than 2 cm highly matched MRI diagnosis. Fibroid size, Ultrasound, Magnetic resonance imaging, Fibroid type, Fibroid site. 779 784 http://ijrr.com/browse.php?a_code=A-10-1-978&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/22 1401/7/30 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 B. Al Omran Al Omran Radiology Department, Bahrain Defense Force Hospital, Riffa, Bahrain drbedooralomran@gmail.com 00319475328460022562 00319475328460022562 Yes A. Mohamed Mehad Mohamed Mehad Royal College of Surgeons in Ireland, Medical University Bahrain, Muharraq, Bahrain 00319475328460022563 00319475328460022563 No S. Matoi Royal College of Surgeons in Ireland, Medical University Bahrain, Muharraq, Bahrain 00319475328460022564 00319475328460022564 No S.M. Abdul Qadir Royal College of Surgeons in Ireland, Medical University Bahrain, Muharraq, Bahrain 00319475328460022565 00319475328460022565 No A. Peluola Royal College of Surgeons in Ireland, Medical University Bahrain, Muharraq, Bahrain 00319475328460022566 00319475328460022566 No R. O’Sullivan Royal College of Surgeons in Ireland, Medical University Bahrain, Muharraq, Bahrain 00319475328460022567 00319475328460022567 No N. Dayoub Assisted Reproduction and Gynecology Center London, United Kingdom 00319475328460022568 00319475328460022568 No

en Background: Although radioiodine-131 (131I) has been widely used for the treatment of Graves' disease (GD), radiation is a potential risk factor for mutagenic abnormalities. This retrospective clinical study mainly aimed to investigate the influence of maternal exposure to 131I used for the treatment of GD prior to pregnancy on chromosomal aberration and intellectual development of offspring in China. Materials and Methods: In total, 69 children whose mothers received 131I for the treatment of GD during childbearing age were included. Data on the obstetric history, medical records, and the birth characteristics of the children were obtained. The thyroid function, thyroid ultrasound, chromosomal structure, and somatic and intellectual development of the children were measured. Results: In all 66 women, the range of the administered 131I was within 228.2 ± 70.3 MBq. The height and weight of all children were within the normal ranges, and one child was confirmed as having subclinical hypothyroidism. Two children were diagnosed with benign thyroid nodules, one child was diagnosed with thyroid cysts, and one child was confirmed as having several anechoic areas in both lobes of the thyroid gland. Chromosomal aberration was observed in one child. None of the children showed any abnormalities in somatic and/or intellectual development. Conclusion: This is the first study to confirm that 131I used for the treatment of GD prior to pregnancy does not significantly increase the risk of chromosomal aberration or impair the intellectual development of offspring.     Graves' disease, 131-I treatment, chromosomal structure, intellectual development. 785 791 http://ijrr.com/browse.php?a_code=A-10-1-979&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/22 1401/7/30 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 J. Zeng Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China 00319475328460022570 00319475328460022570 No J. Wang Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China 00319475328460022571 00319475328460022571 No Q. Guo Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China 00319475328460022572 00319475328460022572 No Y. Hou Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China 00319475328460022573 00319475328460022573 No Q. Lei Department of Paediatrics, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China 00319475328460022574 00319475328460022574 No B. Yao Department of Hematology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China 00319475328460022575 00319475328460022575 No J. Lan Department of Neurology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China 00319475328460022576 00319475328460022576 No D. Zheng Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China 00319475328460022577 00319475328460022577 No Q. Feng Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China 00319475328460022578 00319475328460022578 No Z. Li Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China 00319475328460022579 00319475328460022579 No F. Chen Department of Nuclear Medicine, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China 00319475328460022580 00319475328460022580 No J. Xing Department of Nuclear Medicine, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China 00319475328460022581 00319475328460022581 No Y. Fang Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, No.8, Dong Street, Fengtai District, Beijing 100071, China 00319475328460022582 00319475328460022582 No

en Background: Our aims were to prepare microspheres labelled with radioactive astatine as brachytherapy seeds and to confirm the antitumor ability of these microspheres. Materials and Methods: Chitosan-collagen composite microspheres (CCMs) were synthesized through an emulsification crosslink reaction and radiolabelled with 211At using the chloramine-T method. Radiation stability was assessed in both phosphate-buffered saline and blood serum. The in vivo distribution and therapeutic effects were evaluated in BALB/c nude mice with implanted tumours. Results: CCMs showed ideal morphological characteristics (diameter of 7.5-15 μm) and acceptable radiation stability (73.99% in PBS and 72.56% in serum after 16 hours). The in vivo biodistribution analysis demonstrated that 211At-CCMs were highly localized in tumour tissue. The therapeutic efficacy of 211At-CCMs when intratumorally injected into a cervical tumour model was assessed. Fourteen days after a single-dose treatment with 211At-CCMs, significantly retarded tumour volume growth was observed. Conclusion: 211At-CCM brachytherapy has the potential to provide an alternative solution for tumour treatment.     Brachytherapy, microspheres, radiation oncology, Astatine-211. 793 798 http://ijrr.com/browse.php?a_code=A-10-1-980&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/22 1401/7/30 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 Y. Li Department of Nuclear Medicine, West China Hospital of Sichuan University, China 00319475328460022584 00319475328460022584 No F. Pang Department of Intervention, Shenzhen Traditional Chinese Medicine Hospital, China 00319475328460022585 00319475328460022585 No H. Cai Department of Nuclear Medicine, West China Hospital of Sichuan University, China 00319475328460022586 00319475328460022586 No L. Li Department of Nuclear Medicine, West China Hospital of Sichuan University, China tsflyh@126.com 00319475328460022587 00319475328460022587 Yes

en Background: This study targeted to conclude the effect of cherry juice and fractionated dose γ-irradiation on the fertility of elderly rats. Materials and Methods: Male and female rats were assigned to five groups: young adult control, old adult control, old adult irradiated using 137Cs, source (0.3 Gy*3), old adult cherry juice and cherry irradiated group. Cherry juice was administered orally at the dose 5ml/kg b.w. Follicle stimulating hormone (FSH), estradiol (E2), 8-hydroxy-2-deoxyguanosine (8-OHdG), and insulin-Like Growth Factor 1 (IGF-1) were estimated in the serum of female rats. Serum testosterone (T), FSH, and testicular steroidogenic acute regulatory (STAR) gene expression were evaluated in male rats. Metallothionine (MT), malondialdehyde (MDA) and glutathione (GSH) were estimated in the uterus and testes. Results: Co-treatments of old adult male and female rats with cherry juice and fractionated doses of γ-irradiation developed a significant decrease in MDA in uterus and testes, parallel with an increase in the level of uterus MT and testes GSH as compared with young rats. A significant increase in the levels of female E2, IGF-1, and male T along with a decrease in FSH in both sexes was observed. Additionally, STAR gene expression in male was up regulated. Conclusion: Fractionated dose of gamma radiation (0.3 Gy*3) has no effect on tested reproductive hormones, while Cherry juice stimulates the secretion of E2, and T, and elevates GSH. Tart cherry juice can improve reproductive ability, especially for those undergoing radiotherapy Thus, cherry juice may be a potential candidate to ameliorate the effect of aging on reproductive ability. radioactive Aging rats, STAR, testosterone, estrogen, γ-irradiation. 799 806 http://ijrr.com/browse.php?a_code=A-10-1-981&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/26 1401/8/4 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 H.A. Fahmy Drug Radiation Research Department, National Centre for Radiation Research and Technology, Egyptain Atomic Energy Authority, Cairo, Egypt fahmy.hanan@yahoo.com 00319475328460022589 00319475328460022589 Yes A.M. Hawas Drug Radiation Research Department, National Centre for Radiation Research and Technology, Egyptain Atomic Energy Authority, Cairo, Egypt 00319475328460022590 00319475328460022590 No M.A. Mohamed Drug Radiation Research Department, National Centre for Radiation Research and Technology, Egyptain Atomic Energy Authority, Cairo, Egypt 00319475328460022591 00319475328460022591 No

en Background: The main purpose of the present study was to evaluate the safety and efficiency of concurrent administration of hydroxychloroquine (HCQ) and whole brain radiation therapy (WBRT) in patients with brain metastases. Based on numerous preclinical reports, inhibition of autophagy by HCQ can significantly enhance the efficacy of DNA-damaging therapies improving results of radiation therapy. The primary end point of this study was response to treatment and complications, determined by the National Cancer Institute Common Toxic Criteria for Adverse Events (CTCAE) scale V5.0. Material and Methods: Patients with pathologically-confirmed primary solid malignancies together with single or multiple brain metastases on magnetic resonance imaging (MRI) were enrolled in the study (n=64). Treatment with HCQ (200 mg/P.O. once daily) was begun concurrent with WBRT (total dose of 30 Grays (Gy) in 10 daily fractions) in case group. Control group received the standard regimen. Results: Analysis of complications and response rate at each follow up points revealed no statistically significant differences between the case and control groups. Although, median brain metastasis specific Progression Free Survival (PFS) was non-significantly longer in HCQ group compared to control. No grade 3 or more severe toxicities were reported during therapy in both groups of the study. Conclusion: Although concurrent administration of HCQ with WBRT in patients who suffers from brain metastases was well tolerated, this combination did not meaningfully improve outcomes in comparison to WBRT alone.     Whole brain radiation therapy, hydroxychloroquine, brain metastases, autophagy, radio-sensitizers. 809 813 http://ijrr.com/browse.php?a_code=A-10-1-982&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/262022/10/30 1401/8/8 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 F. Farhan Radiation Oncology Research Center (RORC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran 00319475328460022596 00319475328460022596 No S. Mansouri Radiation Oncology Research Center (RORC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran 00319475328460022597 00319475328460022597 No F. Samiee Radiation Oncology Research Center (RORC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran 00319475328460022598 00319475328460022598 No A. Kazemian Radiation Oncology Research Center (RORC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran 00319475328460022599 00319475328460022599 No B. Kalaghchi Radiation Oncology Research Center (RORC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran 00319475328460022600 00319475328460022600 No M. Lashkari Radiation Oncology Research Center (RORC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran 00319475328460022601 00319475328460022601 No H. Alizadeh Department of Pediatric Radiology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran 00319475328460022602 00319475328460022602 No M. Yamrali Radiation Oncology Research Center (RORC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran maisa36@yahoo.com 00319475328460022603 00319475328460022603 Yes

en Background: To evaluate the predictive value of the 18F-FDG PET/CT parameters on the histopathological features, receptor expression status, and molecular proliferation markers in breast cancer. Also, to assess the effect of the normal breast parenchymal uptake (BPU) on primary breast cancer. Materials and Methods: 287 patients were included, 198 patients with breast cancer (BC) and 89 patients with the healthy breast control group (CG). The metabolic parameters of breast carcinoma were compared with immunohistochemical subtypes, Ki-67 expression status, tumor size, axillary nodal involvement, and distant organ metastasis. We also analyzed the BPU using a 1.5 cm3 volume of interest (VOI) in the BC and CG groups. Results: There was a positive correlation between primary tumor SUVmax and tumor size (p=0.001), high Ki-67 expression (p<0.001), axillary nodal involvement (p<0,001), distant organ metastases (p=0.026), ER and PR negativity, and HER2 positivity (p=0.000, 0.001, and 0.021, respectively). Furthermore, the change in mean SUVmax in molecular subtypes was statistically significant (p<0.001). In addition, the SUVmax measured 0.5 cm from the tumor in the same quadrant is higher than the opposite quadrant and contralateral breast, suggesting that the distance to the tumor increases, the FDG uptake decreases (p<0.001 and 0.001, respectively). Conclusion: Strong relationships were detected between the ER and PR negativity, HER2-positivity, high Ki-67 expression, tumor size, axillary lymph node involvement, distant organ metastases, and SUVmax values. Therefore, we believe that metabolic parameters obtained with 18F-FDG PET/CT may provide relevant information about breast cancer tumor biology and suggest a potential role in identifying more aggressive behavior. FDG PET/CT, breast cancer, breast parenchymal uptake, SUVmax. 815 821 http://ijrr.com/browse.php?a_code=A-10-1-983&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/262022/10/302022/10/30 1401/8/8 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 G. Alçin University of Health Sciences Turkey, Istanbul Training and Research Hospital, Clinic of Nuclear Medicine, Istanbul, Turkey gokselalcin@hotmail.com.tr 00319475328460022605 00319475328460022605 Yes E. Arslan University of Health Sciences Turkey, Istanbul Training and Research Hospital, Clinic of Nuclear Medicine, Istanbul, Turkey 00319475328460022606 00319475328460022606 No T. Aksoy University of Health Sciences Turkey, Istanbul Training and Research Hospital, Clinic of Nuclear Medicine, Istanbul, Turkey 00319475328460022607 00319475328460022607 No S. Akbas University of Health Sciences Turkey, Istanbul Training and Research Hospital, Department of Oncology, Istanbul, Turkey 00319475328460022608 00319475328460022608 No T.F. Cermik University of Health Sciences Turkey, Istanbul Training and Research Hospital, Clinic of Nuclear Medicine, Istanbul, Turkey 00319475328460022609 00319475328460022609 No

en Background: PSMA is known as a suitable marker for imaging and targeted therapy of malignant tumors, especially prostate cancer. While; 177Lu-labeled PSMA is recognized as a promising compound for the treatment of metastatic castration-resistant prostate cancer patients, deployment of radionuclides with higher beta energy, including 188Re, can be useful for larger-sized tumors. However, the absorbed dose of the PSMA radiolabeled compound is substantial according to the considerable accumulation in the kidney. Materials and Methods: In this study; the biodistribution of 188Re-HYNIC-PSMA was studied in Wistar rats. ANACOMP software was utilized for compartmental modeling. The human absorbed dose of this new agent was assessed according to the rats’ biodistribution data using the RADAR method. Results: The highest accumulation of activity in Wistar rats’ organs were observed in the kidney. The human organs that received the highest absorbed dose were the kidneys and bladder wall with 0.69 and 0.46 mSv/MBq, respectively. Conclusion: The absorbed dose of 188Re-PSMA-617 in critical organs is comparable to the values of 177Lu-PSMA-617. 188Re-HYNIC-PSMA can be considered a safe compound for the treatment of PSMA expressing tumors.     Compartmental modeling, absorbed dose, PSMA, 188Re. 823 827 http://ijrr.com/browse.php?a_code=A-10-1-984&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/262022/10/302022/10/302022/10/30 1401/8/8 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 M. Hadisi Department of Energy Engineering, Sharif University of Technology, Tehran, Iran 00319475328460022611 00319475328460022611 No N. Vosoughi Department of Energy Engineering, Sharif University of Technology, Tehran, Iran 00319475328460022612 00319475328460022612 No H. Yousefnia Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran hyousefnia@aeoi.org.ir 00319475328460022613 00319475328460022613 Yes A. Bahrami-Samani Bahrami-Samani Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran 00319475328460022614 00319475328460022614 No S. Zolghadri Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran 00319475328460022615 00319475328460022615 No R. Bagheri Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran 00319475328460022616 00319475328460022616 No

en Background: the aim of this study was to investigate the role of choline glycerophosphate (GPC) either alone or combined with silymarin in modulating whole body gamma irradiation-induced brain and intestinal injuries in rats. Materials and Methods: Rats were irradiated with 7Gy then subjected to GPC and/ or silymarin for two weeks. At the end of the experiment, the animals were sacrificed then, brain and intestine samples were removed for biochemical, molecular and histopathological examinations. Results: it has been detected that GPC alone or combined with silymarin ameliorated the adverse effects of radiation as revealed by the inhibition of oxidative stress, apoptotic and inflammatory markers [Malondialdehyde (MDA), Caspase-3 Tumors necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and nuclear factor kappa-B (NF-kB)]. However, Total antioxidant capacity (TAC), anti-inflammatory marker, Interleukin-10 (IL-10) and inhibitor of Nuclear factor kappa-Ba (IkBa) mRNA were increased. This was also accompanied by a significant increase in the Acetylcholine (ACh) level, Choline Acetyltransferase (ChAT) activity and Alpha-7 nicotinic receptor (α7nAChR), mRNA-expression and a significant decrease in the activity of Acetylcholine esterase (AChE) as compared with the corresponding values of the irradiated group. Moreover, a reduction in the tissue lesions was observed in brain and intestinal tissues. Conclusion: Choline glycerolphosphate and silymarin exhibited modulating effect against detrimental effects of gamma-radiation via cholinergic anti-inflammatory pathway.     γ-radiation, choline glycerophosphate, silymarin, brain and intestinal injury. 829 837 http://ijrr.com/browse.php?a_code=A-10-1-985&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/262022/10/302022/10/302022/10/302022/11/1 1401/8/10 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 N. Abdel-Aziz Radiation Biology Research Department, Health Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), P.O. Box 29, Nasr City, Cairo, Egypt 00319475328460022632 00319475328460022632 No A.A. Elkady Health Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), P.O. Box 29, Nasr City, Cairo, Egypt elkadyah13@gmail.com 00319475328460022633 00319475328460022633 Yes E.M. Elgazzar Health Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), P.O. Box 29, Nasr City, Cairo, Egypt 00319475328460022634 00319475328460022634 No

en Background: Our study was to evaluate the value of contrast-enhanced ultrasonography (CEUS) and contrast-enhanced magnetic resonance imaging (CE-MRI) in analyzing the blood vessels associated with ovarian tumors. Materials and Methods: A total of 100 patients with ovarian tumors underwent CEUS and CE-MRI before surgery. After surgery, the resected ovarian tissues were evaluated via immunohistochemistry to calculate the tumor microvessel density (MVD), and the correlation between the parameters of CEUS and CE-MRI and MVD in ovarian tumors was determined. Results: The MVD level between ovarian tumors was significantly different (p = 0.03); the peak intensity (PI) and area under the curve (AUC) of CEUS parameters in malignant tumors were significantly higher than those in benign tumors (p = 0.03, p = 0.03); and were significantly positively correlated with MVD (r = 0.57, p = 0.00; r = 0.50, p = 0.00). The Ktrans and Ve of CE-MRI parameters in malignant tumors were significantly higher than those in benign tumors (p = 0.01 and p = 0.04), and were also significantly positively correlated with MVD (r = 0.66, p = 0.00; r = 0.55, p = 0.00). Moreover, there was no significant difference between CEUS and CE-MRI in terms of sensitivity (Se), specificity (Sp), negative predictive value (NPV) and positive predictive value (PPV) in malignant ovarian tumors (p > 0.05). Conclusion: Both CEUS and CE-MRI parameters can reflect the MVD level in ovarian tumors; therefore, CEUS is expected to become a viable alternative approach for evaluating ovarian tumors.   Ovarian tumors, microvessel density, contrast-enhanced ultrasound, contrast-enhanced magnetic resonance imaging. 839 843 http://ijrr.com/browse.php?a_code=A-10-1-986&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/262022/10/302022/10/302022/10/302022/11/12022/11/5 1401/8/14 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 M. Yang Department of Ultrasound, Huangshi Maternity & Children’s Health Hospital, Edong Healthcare, Huangshi, Hubei, China 00319475328460022643 00319475328460022643 No X. Liu Department of Ultrasound, Huangshi Maternity & Children’s Health Hospital, Edong Healthcare, Huangshi, Hubei, China 00319475328460022644 00319475328460022644 No H. Su Department of Ultrasound, Huangshi Maternity & Children’s Health Hospital, Edong Healthcare, Huangshi, Hubei, China 00319475328460022645 00319475328460022645 No

en Background: With the advent of Intensity Modulated Radiotherapy (IMRT) and recently, Volumetric Modulated Arc Therapy (VMAT), treatment planning using Flattening Filter Free (FFF) beams can meet all of the energy requirements in radiation therapy clinics. Manufacturers of linear accelerators no longer need to install a flattening filter (FF) in gantry head. This study aims to provide evidence of the superiority of FFF to FF through both dosimetric measurements and clinical treatment plans. Materials and Methods: A 50×50×50cm3 water phantom was created in the RayStation treatment planning system (TPS) for dosimetry comparisons. Flat beam profiles were generated using FFF beam through an optimization process for 10×10 to 30×30cm2 field sizes. Next, a comparison of treatment plans was made using 21 Head and Neck and 14 Lung/Mediastinum treatment sites using 6MV and 6MV-FFF beams. Results: Using FFF beams, profiles with flatness and symmetry identical to or better than those of the flattened beams were produced. At the very edge of the optimized plans for FFF beams, horns had the highest gamma index deviation <1.5% of the normalized dose. For clinical plans evaluated, most of the mean doses to organs-at-risk (OAR) volumes receiving 5% to 30% of the prescription dose were reduced with FFF beams. Conclusion: These results indicate the feasibility of delivering flat beams with FFF quality and producing treatment plans with equal or higher qualities in PTV coverage while achieving better sparing of OAR which will allow escalation of target dose if desired. Plus, removing FF will simplify the gantry head and reduces quality assurance and machine maintenance efforts.       radioactive Flattening filter free, linac, VMAT, sliding window. 845 850 http://ijrr.com/browse.php?a_code=A-10-1-987&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/262022/10/302022/10/302022/10/302022/11/12022/11/52022/11/9 1401/8/18 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 E.I. Parsai Department of Radiation Oncology, University of Toledo Medical Center, 1325 Conference Drive, Toledo, OH 43614, USA ishmael.parsai@gmail.com 00319475328460022674 00319475328460022674 Yes E. Salari Department of Radiation Oncology, University of Toledo Medical Center, 1325 Conference Drive, Toledo, OH 43614, USA 00319475328460022675 00319475328460022675 No D. Shvydka Department of Radiation Oncology, University of Toledo Medical Center, 1325 Conference Drive, Toledo, OH 43614, USA 00319475328460022676 00319475328460022676 No J. Wan Advanced Radiation Physics Service, Inc. Toledo, Ohio Metropolitan Area, Toledo, OH 43614, USA 00319475328460022677 00319475328460022677 No

en Background: Cardiotoxicity is one of the most serious complications of radiation. Nanoparticles, has gained increasing attention as therapeutic agents. This work aims to evaluate the beneficial effect of zinc oxide nanoparticles (ZnONPs) on the cardiotoxicity induced by ionizing radiation. Materials and Methods: Twenty eight male rats were included in the study. Animals were categorized into four groups (n=7),  group I: (control), group II: rats were irradiated with a single dose of ɤ radiation (6Gy), group III: rats injected with ZnONPs (10mg /Kg b.wt), intrapritoneally for two weeks (5days/week), group IV (treated):  irradiated rats received ZnONPs intrapritoneally with the same dose for two weeks after 24hr of irradiation. Results: γ-irradiation caused a significant elevation in the levels of creatine phosphokinase, creatine kinase, lactate dehydrogenase, troponin I, fibrinogen and C-reactive protein. Additionally, a noticeable increase in the lipid content including cholesterol, triglycerides and low density lipoprotein with concomitant decline in high density lipoprotein and finally, a marked decrease in hematological parameters as compared to the control group. These changes manifested good amelioration in the groups injected with ZnONPs. Conclusion: Based on these findings, it can be argued that treatment with ZnONPs reduces the extent of radiation damage by providing significant hypolipidemic, anti-inflammatory and antioxidant effects in irradiated rats. Gamma irradiation, Zn oxide nanoparticles, cardiotoxicity. 851 855 http://ijrr.com/browse.php?a_code=A-10-1-988&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/262022/10/302022/10/302022/10/302022/11/12022/11/52022/11/92022/11/12 1401/8/21 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 M.M. Abbas Biological Applications Department, Isotopes Applications Division, Nuclear Research Center, Egyptian Atomic Energy Authority, Cairo, Egypt dr.manammounir2021@yahoo.com 00319475328460022711 00319475328460022711 Yes A.H. Mahmoud Biological Applications Department, Isotopes Applications Division, Nuclear Research Center, Egyptian Atomic Energy Authority, Cairo, Egypt 00319475328460022712 00319475328460022712 No H.A. Abdelmonem Biological Applications Department, Isotopes Applications Division, Nuclear Research Center, Egyptian Atomic Energy Authority, Cairo, Egypt 00319475328460022713 00319475328460022713 No

en Background: NatuAt present, radioactive seed implantation is a common treatment for prostate cancer, the TPS (treatment planning system) calculates the dose by adding the dose attributed to each source. However, the interseed attenuation effect would result in a difference between the actual dose and the calculated dose. The aim of this study was to identify the factors influencing the interseed attenuation effect. Materials and Methods: I-125 seed sources were selected, and MC (Monte Carlo) method was used to simulate the dose distribution around seed sources. The results obtained from the linear addition of a single-source dose were compared with those obtained considering the interseed attenuation effect. The effects of the medium, source arrangement and source number on the dose were evaluated. Results: The MC simulation results for multiple seed sources are lower than those for linear additive doses in most areas. In different medium, the mean error caused by interseed attenuation effect is the smallest in adipose tissue (0.52%) and the largest in bone (1.41%). Taking four sources as examples, the maximum error is 9.34%, appearing in the plane where the source is located. The error decreases to 1.3% when the source is located 2 mm away from the source plane. The more scattered the sources are in space, the smaller the error will be. Conclusions: A high atomic number and high-density medium will cause a high error. The area with a high error is mainly observed in the plane where the sources are located, the edge error of the source distribution area is larger. radioactive seed implantation, interseed attenuation effect, Monte Carlo, I-125 seed source. 857 864 http://ijrr.com/browse.php?a_code=A-10-1-989&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/262022/10/302022/10/302022/10/302022/11/12022/11/52022/11/92022/11/122022/11/13 1401/8/22 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 H. Gao State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China 00319475328460022715 00319475328460022715 No Y. Wang State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China 00319475328460022716 00319475328460022716 No C. Du State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China 00319475328460022717 00319475328460022717 No X. Li State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China 00319475328460022718 00319475328460022718 No K. Liu State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China 00319475328460022719 00319475328460022719 No H. Xue State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China 00319475328460022720 00319475328460022720 No W. Tang State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China 00319475328460022721 00319475328460022721 No L. Chen State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China 00319475328460022722 00319475328460022722 No C. Yan State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China 00319475328460022723 00319475328460022723 No Y. Tu State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China 00319475328460022724 00319475328460022724 No L. Sun State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China slhmz666@suda.edu.cn 00319475328460022725 00319475328460022725 Yes

en Background: To investigate the clinical efficacy of hyperthermic intraperitoneal chemotherapy in combination with the malignant ascites in gastric cancer following the Intensive preoperative radiotherapy for radical surgery of tumor. Materials and Methods: We selected a total of 112 gastric cancer patients who had been operated on for radical surgery of tumor in this hospital as subjects that were randomized into the control group and the observation group, with 56 patients in each group. Patients in the control group took the abdominal aspiration in combination with the intravenous chemotherapy, while those in the observation group underwent the hyperthermic intraperitoneal chemotherapy. After treatment, we compared the effectiveness rate, levels of tumor markers, incidence rates of adverse reactions, and  Karnofsky (KPS) scores between the two groups. Results: In the observation group and the control group, the effectiveness rates of patients were 71.43% and 44.64%, showing the statistical significance of the difference (P < 0.05); after treatment, the levels of CEA, CA125, and CA199, tumor markers, were decreased compared to before treatment (P < 0.05). The incidence rates of adverse reactions were 75.00% and 82.14%, showing no statistical significance of difference (P > 0.05). Following the treatment, the KPS scores were improved in two groups compared to before treatment (P < 0.05). Conclusion: For gastric cancer patients with malignant ascites, hyperthermic intraperitoneal chemotherapy excels in the clinical efficacy by decreasing the level of tumor markers, to improve the life quality of patients, but with no increase in the incidence rate of adverse reactions. Pelvis, Environmental radioactivity, internal hazard, gamma emitters, NaI (Tl), soil, Najaf schools. 865 869 http://ijrr.com/browse.php?a_code=A-10-1-990&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/262022/10/302022/10/302022/10/302022/11/12022/11/52022/11/92022/11/122022/11/132022/11/14 1401/8/23 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 Z. Wang Department of Surgical Oncology, The First People’s Hospital of Lanzhou, Lanzhou, Gansu730050, China 00319475328460022727 00319475328460022727 No P. Wang Department of Internal Medicine, Nanjing Gaochun People's Hospital, Jiangsu Province, Nanjing, Jiangsu 211300, China 00319475328460022728 00319475328460022728 No L. Lv Department of Internal Medicine, Nanjing Gaochun People's Hospital, Jiangsu Province, Nanjing, Jiangsu 211300, China 00319475328460022729 00319475328460022729 No Y. Liu Department of Hand and Foot Surgery, Subei People's Hospital of Jiangsu province, Yangzhou, Jiangsu 225000, China 00319475328460022730 00319475328460022730 No C.J. Sun Department of Oncology, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu 225000, China prof.lililuolililuo253@gmail.com 00319475328460022731 00319475328460022731 No

en Background: It is generally accepted that smokers are more prone to lung cancers, however non-smokers also are at high risk if they are exposed to higher concentration of radon. Radon has been the major source of this alpha particle. Materials and Methods: The use of water in day to day activities has immensely increase the rate of exposure to radon in indoor. Therefore, 42 water samples (30 well and 12 borehole water) use for such domestics activities were systemically collected from different places for radon probing with the aid of an electronic active detector RAD7 produced by Durridge USA. The annual inhalation and ingestion were also estimated from the water samples. Result: After probing the radon in the water samples, the obtained results ranged for well and borehole water samples were 0.08 to 14.8 Bq/l and 0.004 to 5.41 Bq/l respectively. Statistical analysis results confirmed that there is a significant difference between the mean value of radon concentration in different sources of water from both well and borehole, (p=0.000). The estimated inhalation and ingestion doses were lower than the world average reference level. Conclusion: The areas with higher radon concentration in their water samples should take necessary actions to avoid consequences from exposure to higher radon. The total annual effective dose due to inhalation and ingestion were estimated to be 10.0 µSv/y for well water and 8.579 µSv/y for bore hole water which were lower than the recommended action level of 0.1 mSvy-1 set by WHO. Lung cancer, radon, drinking water. 871 877 http://ijrr.com/browse.php?a_code=A-10-1-991&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/262022/10/302022/10/302022/10/302022/11/12022/11/52022/11/92022/11/122022/11/132022/11/142022/11/15 1401/8/24 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 E.A. Oni Department of Pure and Applied Physics, Ladoke Akintola University of Technology, Ogbomoso, Nigeria emand1215@gmail.com 00319475328460022748 00319475328460022748 Yes O.O. Oladapo Department of Science Laboratory Technology, Ladoke Akintola University of Technology, Ogbomoso, Nigeria 00319475328460022749 00319475328460022749 No A.A. Aremu Department of Pure and Applied Physics, Ladoke Akintola University of Technology, Ogbomoso, Nigeria 00319475328460022750 00319475328460022750 No

en Background: Computed tomography (CT) is a highly effective imaging technique for abdominopelvic pathologies. Nonetheless, radiation concerns arise due to patients receiving a significant effective dose (ED). Thus, patient dose evaluation is critical to ensure that benefits compensate for the projected cancer risk. The current study aimed to assess abdominopelvic CT radiation exposure. Material and Methods: A cross-sectional analytical design was conducted for 130 abdominopelvic CT procedures. The WAZA-ARI version 2 CT dosimetry system, which is web-based, open Monte Carlo simulation software for CT dose computations was used to calculate organ doses. Lifetime attributable risk (LAR) of cancer induction was calculated for dual-phase abdominopelvic CT through the website “Xrayrisk.com”. Results: Results revealed that the mean ED was slightly lower in females compared to males (13.9±2.9 mSv vs. 15.5±2.7 mSv). The mean EDs for male patients in the arterial and venous phases were 6.2±1.08 mSv and 9.3±1.62, respectively, while the corresponding mean EDs  for female patients were 5.56±1.16 mSv and 8.34±1.74. The highest organ equivalent doses for both genders and among all exams were gonads (males 32.55, females 28.76 mSv); small intestine (males 30.26, females 26.66 mSv); colon (males 29.79, females 26.33 mSv), and stomach (males 28.55, females 25.23 mSv). Conclusion: Variations among organ doses and assumptions regarding negligible risk of malignancy inform current hospital policy.  Our findings suggest that achieving the balance between diagnostic benefits and radiation risk requires careful attention. Dual-phase abdominopelvic CT, patient radiation exposure. 879 882 http://ijrr.com/browse.php?a_code=A-10-1-992&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/262022/10/302022/10/302022/10/302022/11/12022/11/52022/11/92022/11/122022/11/132022/11/142022/11/152022/11/15 1401/8/24 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 K.M. Abushab Medical Imaging Department, Al-Azhar University, Gaza, Palestine khaledshap@hotmail.com 00319475328460022751 00319475328460022751 Yes H.H. Mansour Medical Imaging Department, Al-Azhar University, Gaza, Palestine 00319475328460022752 00319475328460022752 No Y.S. Alajerami Medical Imaging Department, Al-Azhar University, Gaza, Palestine 00319475328460022753 00319475328460022753 No

en Natural Cat scratch disease is caused by the infection of Bartonella henselae after a cat scratch, bite, or close contact, and mainly presents with skin lesions and swollen lymph nodes in the drainage area. Herein, we report a 71-year-old female cat scratch disease patient who initially presented with low fever and enlarged lymph nodes on the left side of her neck, who underwent fluorine-18 labeled fluorodeoxyglucose positron emission tomography/computed tomography for suspected lymphoma. As increased fluorodeoxyglucose uptake can indicate inflammation or tumor, and lymph node enlargement accompanied by abnormal metabolism can mimic lymphoma or other diseases, the diagnosis of cat scratch disease is difficult. Its diagnosis should be indicated when unilateral lymphadenopathy is accompanied by abnormally high metabolic uptake of fluorodeoxyglucose. Cat scratch disease, 18F-FDG, PET/CT, lymphoma. 883 885 http://ijrr.com/browse.php?a_code=A-10-1-994&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/262022/10/302022/10/302022/10/302022/11/12022/11/52022/11/92022/11/122022/11/132022/11/142022/11/152022/11/152022/11/15 1401/8/24 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 X. Hu Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, PR China, 563003 00319475328460022755 00319475328460022755 No H. Hu Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, PR China, 563003 00319475328460022756 00319475328460022756 No R. Yu Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, PR China, 563003 00319475328460022757 00319475328460022757 No X. Cai Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, PR China, 563003 00319475328460022758 00319475328460022758 No P. Yang Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, PR China, 563003 00319475328460022759 00319475328460022759 No J. Cai Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, PR China, 563003 jiong_cai@163.com 00319475328460022760 00319475328460022760 Yes

other Background: Epithelioid sarcoma (ES) is a rare soft tissue tumor that mainly occurs under the skin of the extremities. ES in the groin area may be easily misdiagnosed with undifferentiated pleomorphic sarcoma, leiomyosarcoma, rhabdomyosarcoma, and other mesenchymal tumors. Herein, we reported a single case of a patient with proximal-type epithelioid sarcoma of the groin, including its clinical and imaging findings. We also discussed some previously reported similar cases. Case Presentation: Our ES patient was a 24-year-old male who developed a subcutaneous nodule in the groin area 1 year before admission. After careful clinical and pathological examination, the patient was diagnosed with ES. He received chemotherapy (<a href="file:///D:/../AppData/Local/Microsoft/Windows/INetCache/asus1---/AppData/Local/youdao/dict/Application/8.9.9.0/resultui/html/index.html#/javascript:;">doxorubicin, ifosfamide plus cisplatin) and, later on, surgery. His symptoms improved, and he is still being followed up. In addition, we conducted a review of the literature and compared our data with 12 previously reported similar cases (including 17 patients with ES involving the groin). Conclusion: ES is a highly invasive tumor prone to metastasis and postoperative recurrence. Surgery seems to be the most effective treatment for ES. The effectiveness of auxiliary and radiotherapy needs to be confirmed by a large amount of data. A systematic understanding of the clinical and imaging features of ES in the groin area may help clinical and imaging doctors to correctly diagnose the disease. Epithelioid sarcoma, groin, mesenchymal tumor, case report. 887 892 http://ijrr.com/browse.php?a_code=A-10-1-995&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/262022/10/302022/10/302022/10/302022/11/12022/11/52022/11/92022/11/122022/11/132022/11/142022/11/152022/11/152022/11/152022/11/15 1401/8/24 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 X. Hu Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563003, PR China 00319475328460022773 00319475328460022773 No C. Zhang Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563003, PR China 00319475328460022774 00319475328460022774 No K. Qian Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563003, PR China 00319475328460022775 00319475328460022775 No R. Yu Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563003, PR China 00319475328460022776 00319475328460022776 No T. Mei Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563003, PR China 00319475328460022777 00319475328460022777 No J. Cai Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563003, PR China jiong_cai@163.com 00319475328460022778 00319475328460022778 Yes

en Pulmonary ventilation/perfusion (V/Q) scintigraphy is often used for the diagnosis of pulmonary embolism. However, it should be noted that the perfusion defect shown by pulmonary perfusion imaging is not the only manifestation of pulmonary embolism. Any disease that causes pulmonary vasculature stenosis and occlusion can cause pulmonary blood flow perfusion impaired. We report a case of fibrosing mediastinitis (FM) with pulmonary hypertension as a complication of pulmonary artery and pulmonary vein stenosis. Based on clinical symptoms, laboratory test and multiple radiographic findings, the diagnosis of FM was established. The patient underwent balloon dilation and stent implantation of right upper lobe pulmonary vein, as well as balloon dilatation of right upper lobe pulmonary artery, whose symptoms was immediately improved during the following investigation. pulmonary perfusion scintigraphy, fibrosing mediastinitis, pulmonary artery stenosis, pulmonary vein stenosis, interventional therapy, SPECT/CT. 893 896 http://ijrr.com/browse.php?a_code=A-10-1-996&slc_lang=en&sid=1 2022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/222022/10/262022/10/302022/10/302022/10/302022/11/12022/11/52022/11/92022/11/122022/11/132022/11/142022/11/152022/11/152022/11/152022/11/152022/11/15 1401/8/24 2022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/182022/10/18 1401/7/26 R. Wang Department of Nuclear Medicine, Gansu Provincial Hospital, Lanzhou 730000, China 00319475328460022769 00319475328460022769 No Z. LI First Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou 730000, China 00319475328460022770 00319475328460022770 No Y. Wang Department of Nuclear Medicine, Gansu Provincial Hospital, Lanzhou 730000, China 00319475328460022771 00319475328460022771 No H. Wang Department of Nuclear Medicine, Gansu Provincial Hospital, Lanzhou 730000, China whj1425@126.com 00319475328460022772 00319475328460022772 Yes