en jalali 1403 1 1 gregorian 2024 4 1 22 2 online 1 fulltext

en Background: Multimodal medical imaging plays a key role in the diagnosis and differential diagnosis of myocarditis, enabling a comprehensive assessment of cardiac structure and function. Materials and Methods: We used multimodal medical imaging technology to diagnose and differential diagnose patients with myocarditis, and analyzed the patient data in detail. Results: Multimodal medical imaging techniques provide a wealth of information to help distinguish myocarditis from other heart diseases. Conclusion: Multimodal medical imaging is of great value in the diagnosis and differential diagnosis of myocarditis, but there are still some challenges and limitations in its application. Multimodal medical imaging, differential diagnosis, myocarditis, cardiac function, imaging technology. 243 250 http://ijrr.com/browse.php?a_code=A-10-1-1165&slc_lang=en&sid=1 2024/04/17 1403/1/29 2024/04/22 1403/2/3 W. Wang Heilongjiang University of Chinese Medicine, Heilongjiang, China 00319475328460026634 00319475328460026634 No D. Feng Heilongjiang University of Chinese Medicine, Heilongjiang, China 00319475328460026635 00319475328460026635 No Q. Song Heilongjiang University of Chinese Medicine, Heilongjiang, China 00319475328460026636 00319475328460026636 No W. Sun Heilongjiang University of Chinese Medicine, Heilongjiang, China 00319475328460026637 00319475328460026637 No D. Zhang Heilongjiang University of Chinese Medicine, Heilongjiang, China 00319475328460026638 00319475328460026638 No M. Li Heilongjiang University of Chinese Medicine, Heilongjiang, China 00319475328460026639 00319475328460026639 No K. Li Heilongjiang University of Chinese Medicine, Heilongjiang, China 00319475328460026640 00319475328460026640 No H. Chen Department of Pediatrics, First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Heilongjiang, China 18845058624@163.com 00319475328460026641 00319475328460026641 Yes F. Li Heilongjiang University of Chinese Medicine, Heilongjiang, China 00319475328460026642 00319475328460026642 No

en Background: Breast cancer is a common cancer that affects women. The Luminal A subtype of breast cancer is defined by low Ki67 expression (<14%), Her-2 negative, and positive ER and PR. Luminal A exhibits a favorable prognosis compared to other breast cancer types. Materials and Methods: Gene expression profiling was employed in this investigation to discover genes linked to clinical efficacy and recurrence in Luminal A breast cancer tissue samples. The study's overarching goal was to discover new therapeutic targets by deciphering the molecular mechanisms behind Luminal A breast cancer. Results: Our analysis revealed specific genes linked to Luminal A breast cancer, and their expression levels were correlated with clinical outcomes. High expression of certain genes was associated with improved clinical efficacy and a reduced recurrence rate. Conclusion: The study provides valuable insights into the molecular mechanisms of Luminal A breast cancer, offering potential targets for personalized therapeutic approaches. Breast neoplasms, luminal a subtype, gene expression, clinical efficacy, recurrence. 251 256 http://ijrr.com/browse.php?a_code=A-10-1-1166&slc_lang=en&sid=1 2024/04/172024/04/17 1403/1/29 2024/04/222024/04/22 1403/2/3 J. Ma Department of General Surgery, the Second Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China 00319475328460026644 00319475328460026644 No T. Gan Department of Orthopedics, the Second Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China 00319475328460026645 00319475328460026645 No A. Song Department of General Surgery, the Second Hospital of Lanzhou University, Lanzhou, 730000, Gansu, China songail@lzu.edu.cn 00319475328460026646 00319475328460026646 Yes

en Background: Evaluation of Size-Specific Dose Estimation (SSDE) by patient's weight and Body Mass Index (BMI) instead of Anterior-Posterior (AP) and Lateral (LAT) diameter measurements in patient's images for lung computed tomography (CT). Materials and Methods: Before the examination, the weight and BMI of all patients were measured and calculated. All AP and LAT diameters were measured from the axial images, and localizer and conversion factors (fsize) were calculated based on them. Volume Computed Tomography Dose Index (CTDIvol) and Dose Length Product (DLP) values were also recorded from the patient's examination summary. In this way, different SSDEs based on effective diameter (SSDEeff), water equivalent diameter(SSDEw), AP diameter (SSDEAP), LAT diameter (SSDELAT), sum of the AP and LAT diameters (SSDEAP+LAT), AP diameter in scout view (SSDEAPscout) and LAT diameter in scout view (SSDELATscout) are obtained. By Pearson statistical test the correlation between patients' BMI and weight with all types of SSDE calculation methods was examined. Results: There was a statistically significant correlation between all measured and compared parameters, but the most correlation between BMI and weight with SSDEs was obtained with SSDEeff (R=0.825, P<0.05) and SSDEw (R=0.777, P<0.05), respectively. Also, the correlation between BMI and effective diameter (deff) (R=0913, P<0.05) is the highest among all types of diameters measured. The correlation of BMI with SSDEw and water equivalent diameter (dw) was (R=0.807, P<0.05), (R=0.909, P<0.05), respectively. Conclusion: There seems to be a significant correlation between BMI andf_size so that we can estimate patients' SSDE without measuring AP and LAT diameters, even before a CT scan. size-specific dose estimate, CT scan, patient's BMI, body diameter. 257 264 http://ijrr.com/browse.php?a_code=A-10-1-1167&slc_lang=en&sid=1 2024/04/172024/04/172024/04/17 1403/1/29 2024/04/222024/04/222024/04/22 1403/2/3 I.  Azinkhah Fintech in Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran 00319475328460026648 00319475328460026648 No M. Sadeghi Fintech in Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran sadeghi.m@iums.ac.ir 00319475328460026649 00319475328460026649 Yes

en Background: In the present study, PET/CT imaging characteristics were explored to investigate the prognostic value of 18F–fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in oesophageal squamous cell carcinoma (ESCC). Materials and Methods: Baseline PET/CT and clinical characteristics were collected in 125 patients with ESCC treated with radical radiotherapy from 2007–2016. The maximum standardized uptake value (SUVmax) of the primary gross tumour (SUVmax-T) and metastatic lymph nodes (SUVmax-N) were separately measured using X-tile. Overall survival (OS) and progression free survival (PFS) were estimated according to the Kaplan–Meier method. A multivariate Cox model was used to establish the independent prognostic factors. Results: The gross tumours presented higher 18F-FDG uptake than normal tissues. The OS and PFS did not show significant differences between patients with different SUVmax-T values. However, patients with SUVmax-N ≥ 11 had a significantly worse OS and PFS than those with SUVmax-N <11 (P<0.05). A weak correlation was observed in SUVmax-T and SUVmax-N. The OS and PFS of patients with PET-negative lymph nodes (LNs) were significantly better than those with PET-positive LNs. However, the OS and PFS of patients with one or two PET-positive LNs were not significantly better than those with more than two PET-positive LNs. In multivariate analysis, SUVmax-N was suggested to be an independent predictor for OS and PFS. Conclusions: SUVmax-N, but not SUVmax-T, is an independent prognostic indicator for patients with ESCC. SUV, positron emission tomography, metabolic lymph node, survival. 265 270 http://ijrr.com/browse.php?a_code=A-10-1-1168&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/17 1403/1/29 2024/04/222024/04/222024/04/222024/04/22 1403/2/3 J. Deng Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Shanghai, 200032, China 00319475328460026651 00319475328460026651 No W. Ren Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Shanghai, 200032, China 00319475328460026652 00319475328460026652 No J. Shen Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Shanghai, 200032, China 00319475328460026653 00319475328460026653 No L. Ma Department of Oncology, Shanghai Medical College, Fudan University; Shanghai, 200032, China 00319475328460026654 00319475328460026654 No K. Zhao Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Shanghai, 200032, China zhaokuaile1153@163.com 00319475328460026655 00319475328460026655 Yes

en Background: Diagnosing knee osteoarthritis (KOA) often relies on limited routine methods. This study investigates the efficacy of T2 mapping and Apparent Diffusion Coefficient (ADC) values in MRI for enhanced assessment of cartilage damage in KOA, focusing on their correlation with pain severity. Materials and Methods: A total of 52 KOA patients (74 knee joints) and 50 healthy individuals (100 knee joints) were assessed from May 2022 to June 2023. Both groups underwent MRI with Diffusion Weighted Imaging (DWI) sequence and T2 mapping to analyze ADC and T2 mapping values across femoral condyle, tibial plateau, and patellar joint surfaces, and their correlation with pain levels. Results: The KOA group showed significantly higher ADC and T2 mapping values in all examined areas compared to the control group (P<0.05). These values were also higher in advanced stages of cartilage degeneration and correlated positively with increased pain scores (P<0.05). Conclusion: MRI utilizing DWI and T2 mapping provides a quantitative reflection of knee joint cartilage degeneration in KOA. These methods show a positive correlation with pain severity, suggesting their potential for more accurate KOA diagnostics and assessment. Knee osteoarthritis (KOA), magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), T2 mapping, cartilage degeneration. 271 275 http://ijrr.com/browse.php?a_code=A-10-1-1169&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/30 1403/2/11 2024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 C.Z. Huang Department of Radiological, The second Affiliated Hospital of Hainan Medical University, Hainan, China 00319475328460027057 00319475328460027057 No C.K. Lin Department of Radiological, The second Affiliated Hospital of Hainan Medical University, Hainan, China 724897505@qq.com 00319475328460027058 00319475328460027058 Yes Q.M. Fu Department of Radiological, The second Affiliated Hospital of Hainan Medical University, Hainan, China 00319475328460027059 00319475328460027059 No J.H. Huang Department of Radiological, The second Affiliated Hospital of Hainan Medical University, Hainan, China 00319475328460027060 00319475328460027060 No N.L. Jia Department of Radiological, The second Affiliated Hospital of Hainan Medical University, Hainan, China 00319475328460027061 00319475328460027061 No Y. Chen Department of Radiological, The second Affiliated Hospital of Hainan Medical University, Hainan, China cheny86a@163.com 00319475328460027062 00319475328460027062 No

en Background: The presence of tertiary lymphoid structures (TLS) is related with good prognosis of various cancers including bladder cancer. The majority of bladder tumors are identified as non-muscle-invasive bladder cancer (NMIBC) when they are discovered in their early stages. We aimed to evaluate the prognostic value and clinical relevance of TLS in NMIBC. Materials and Methods: This cohort included 130 NMIBC samples, with 39 (30%) having TLS, as confirmed by hematoxylin and eosin and immunohistochemistry staining. The chi-square test was utilized to examine the relationship between TLS and the biomarkers and clinicopathologic characteristics of NMIBC. Results: It was found that TLS has significant association with pT stage, Ki-67 expression, and COX-2 expression. Using Kaplan-Meier analysis and Gehan-Breslow-Wilcoxon test, we found that the presence of TLS is associated with longer recurrence-free survival and overall survival of NMIBC patients. Moreover, we used bioinformatics to analyze the association of TLS marker L1CAM and bladder cancer. L1CAM is downregulated in bladder cancer, linked to an advanced stage of the disease, and indicates a poorer prognosis for those who have bladder cancer. In bladder cancer, there is a positive correlation between its expression and B cell infiltration. We also indicated that NMIBC with TLS have a higher level of TLS than that without TLS. Conclusion: To conclude, the presence of TLS is an important favorable prognostic indicator in NMIBC. A further understanding on TLS can provide new insights to improve immunotherapy for bladder cancer. Tertiary lymphoid structure, non-muscle-invasive bladder cancer, clinical relevance. 277 282 http://ijrr.com/browse.php?a_code=A-10-1-1170&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/30 1403/2/11 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 JB. Ji Department of Urology, Yancheng Third People's Hospital (The Yancheng School of Clinical Medicine of Nanjing Medical University), Yancheng, Jiangsu 224001, China. 00319475328460026862 00319475328460026862 No PC. Li Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu 210029, China lipengchao_edu@outlook.com 00319475328460026863 00319475328460026863 Yes TT. Yuan Department of Urology, Yancheng Third People's Hospital (The Yancheng School of Clinical Medicine of Nanjing Medical University), Yancheng, Jiangsu 224001, China. 00319475328460026864 00319475328460026864 No ZK. Qu Department of Urology, Yancheng Third People's Hospital (The Yancheng School of Clinical Medicine of Nanjing Medical University), Yancheng, Jiangsu 224001, China. 00319475328460026865 00319475328460026865 No GX. Song Department of Urology, Yancheng Third People's Hospital (The Yancheng School of Clinical Medicine of Nanjing Medical University), Yancheng, Jiangsu 224001, China. 00319475328460026866 00319475328460026866 No ML. Bao Department of Urology, Yancheng Third People's Hospital (The Yancheng School of Clinical Medicine of Nanjing Medical University), Yancheng, Jiangsu 224001, China. 00319475328460026867 00319475328460026867 No XD. Liang Department of Urology, Yancheng Third People's Hospital (The Yancheng School of Clinical Medicine of Nanjing Medical University), Yancheng, Jiangsu 224001, China. 00319475328460026868 00319475328460026868 No B. Jiang Department of Urology, Yancheng Third People's Hospital (The Yancheng School of Clinical Medicine of Nanjing Medical University), Yancheng, Jiangsu 224001, China. 00319475328460026869 00319475328460026869 No XL. Yin Department of Urology, Yancheng Third People's Hospital (The Yancheng School of Clinical Medicine of Nanjing Medical University), Yancheng, Jiangsu 224001, China. 00319475328460026870 00319475328460026870 No YY. Wang Department of Urology, Yancheng Third People's Hospital (The Yancheng School of Clinical Medicine of Nanjing Medical University), Yancheng, Jiangsu 224001, China. 00319475328460026871 00319475328460026871 No H. Ji Department of Urology, Yancheng Third People's Hospital (The Yancheng School of Clinical Medicine of Nanjing Medical University), Yancheng, Jiangsu 224001, China. 00319475328460026872 00319475328460026872 No

en Background: To evaluate the value of six tumor markers including squamous cell carcinoma antigen (SCCA), cytokeratin 19 fragment (CYFRA21-1), carcinoembryonic antigen (CEA), glycoconjugate antigen 125 (CA125), neuron-specific enolase (NSE), along with gastrin-releasing peptide precursor (ProGRP) in the diagnosis and pathological staging of lung cancer (LC) alone or in combination. Materials and Methods: A retrospective analysis was performed on 300 patients of which 62 cases were diagnosed as small cell lung cancer (SCLC), 105 adenocarcinoma (LUAD), 41 squamous cell carcinoma (LUSC) and 92 large cell lung cancer (LCLC) by histopathology. Another 364 patients with benign lung disease in the same period were chosen for the benign lung disease group. Results: The detection results of 6 tumor markers in serum of LC, SCCA, NSE and ProGP patients with different pathological types were higher compared with lung benign lesions group (P<0.01). LC can be separated into SCLC along with non-Small cell lung cancer (NSCLC) by NSE+ProGRP combination. The detection rate of lung squamous cell carcinoma by SCCA+ cytokeratin 19 fragment (CYFRA21-1) was higher than that by CEA+CA125 combination for adenocarcinoma. The combined determination of NSE and ProGRP was highly sensitive to SCLC. In NSCLC, the combined detection of SCC-Ag and CYFRA21-1 showed high sensitivity to LUSC. CEA+CA125 combined detection was highly sensitive to LUAD. Conclusion: The combined determination of NSE and ProGRP was highly sensitive to SCLC. CEA+CA125 combined detection was highly sensitive to LUAD, and SCCA+CYFR21-1+CEA+CA125 was the best combined detection analysis of multiple indexes. Squamous cell carcinoma antigen, CYFRA21-1, carcinoembryonic antigen, lung cancer. 283 287 http://ijrr.com/browse.php?a_code=A-10-1-1171&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/30 1403/2/11 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 RM. Zhou Department of Respiratory and Critical Care Medicine, Gaozhou People's Hospital, Gaozhou, Guangdong 525200, China 00319475328460026767 00319475328460026767 No ZH. Cai Department of Respiratory and Critical Care Medicine, Gaozhou People's Hospital, Gaozhou, Guangdong 525200, China 00319475328460026768 00319475328460026768 No YR. Yuan Department of Respiratory and Critical Care Medicine, Gaozhou People's Hospital, Gaozhou, Guangdong 525200, China 00319475328460026769 00319475328460026769 No ZL. Zhou Department of Respiratory and Critical Care Medicine, Gaozhou People's Hospital, Gaozhou, Guangdong 525200, China 00319475328460026770 00319475328460026770 No H. Ding Department of Respiratory and Critical Care Medicine, Gaozhou People's Hospital, Gaozhou, Guangdong 525200, China 00319475328460026771 00319475328460026771 No YQ. Cheng Department of Respiratory and Critical Care Medicine, Gaozhou People's Hospital, Gaozhou, Guangdong 525200, China 00319475328460026772 00319475328460026772 No L. Liang Department of Respiratory and Critical Care Medicine, Gaozhou People's Hospital, Gaozhou, Guangdong 525200, China gyliangli@outlook.com 00319475328460026773 00319475328460026773 Yes ZN. Tuo Department of Respiratory and Critical Care Medicine, Gaozhou People's Hospital, Gaozhou, Guangdong 525200, China tuozineng888@163.com 00319475328460026774 00319475328460026774 No

en Background: Radiotherapy is an important and effective modality in treating cancer patients. Radiation-induced cardiovascular injury is one of the consequences of radiotherapy due to undesired exposure of the heart. The non-targeted effects of radiation add to the risk of cardiovascular injury following radiotherapy. Accordingly, we investigated the abscopal effect of radiation in the myocardium of partially irradiated rats and compared the abscopal effect with the effect induced in the myocardium following either direct or sham irradiation. Materials and Methods: Twenty male rats divided into four groups; sham, 2Gy whole-body, 2Gy cranially- and 2Gy lower-limb irradiated, were used. Myocardium samples were collected and examined for MDA, p53, caspase 3, and glutathione reduced expression. Additionally, TGF-β and NF-κB expression levels were investigated. Results: Our data revealed elevated levels of lipid peroxidation in abscopal myocardium following cranial- /lower-limb irradiation with 2 Gy γ-radiation, as compared with the sham or whole-body irradiated groups. Similar behavior was noticed with p53 and caspase3 expression, suggesting apoptosis induction in the abscopal cardiomyocytes. The rise in lipid peroxidation and apoptosis markers in the abscopal myocardium was associated with an increase in glutathione reduced. The data propose oxidative stress induction in the myocardium following distant irradiation, which was further confirmed by the elevation in TGF-β and nuclear NF-κB expression. Conclusion: Abscopal effect was induced in the myocardium of partially-irradiated rats, suggesting increased risk of myocardial injury following localized radiotherapy. Ionizing radiation, abscopal effect, lipid peroxidation, oxidative stress, cytokines. 289 295 http://ijrr.com/browse.php?a_code=A-10-1-1172&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/1 1403/2/12 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 L.M. Ramadan Biochemistry Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt. 12622 00319475328460026776 00319475328460026776 No A.B. Abdelrazzak Spectroscopy Department, Physics Research Institute, National Research Centre, Cairo, Egypt. 12622 a.b.abdelrazzak@gmail.com 00319475328460026777 00319475328460026777 Yes

en Background: To investigate the role of pregnant-associatedplasma protein A (PAPP-A) and uterine artery Doppler ultrasound in predicting fetal growth restriction (FGR). Materials and Methods: In total, 120 pregnant women diagnosed with FGR in Shijiazhuang Obstetrics and Gynecology Hospital from January 2021 to December 2023 were selected as the FGR group, and 120 normal pregnant women were selected as the control group during the identical time frame. Maternal serum pregnancy-related protein A combined with uterine artery Doppler ultrasonography was performed during the period from the 11th, to the 13th+6 weeks of pregnancy. The course of pregnancy was observed in both groups of pregnant women. Results: The FGR group exhibited significantly reduced rates of vaginal delivery and fetal survival compared to the control group, while experiencing higher rates of preterm delivery and cesarean section, with statistical significance (P<0.001). The pulsatility index of the uterine artery (UtA-PI) and the resistance index of the uterine artery and the FGR group exhibited a higher proportion of early blood diastolic incisors compared to the normal group, with statistical significance noted at a level of P<0.001. The concentration of PAPP-A was lower than that of normal group (P<0.001). The sensitivity of combining UtA-PI and PAPP-A to predict FGR was 81.6%, and the sensitivity of combining UtA-PI and PAPP-A is 82.9%, which is 1.3% higher, but there was no statistically significant distinction between the two approaches (P>0.05). Conclusion: The implementation the combination between PAPP-A and Doppler ultrasound is an effective method to predict FGR. Doppler ultrasound, PAPP-A, fetal growth restrictionFGR. 297 302 http://ijrr.com/browse.php?a_code=A-10-1-1173&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/11 1403/2/22 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 F. Li The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050000, China 13472192605@163.com 00319475328460026858 00319475328460026858 Yes F. Liu The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050000, China 00319475328460026859 00319475328460026859 No W. Song The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050000, China 00319475328460026860 00319475328460026860 No H. Li The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050000, China 00319475328460026861 00319475328460026861 No

en Background: It is essential to evaluate the accuracy of dose calculation for treatment planning systems (TPSs). This study's primary goal was to evaluate the accuracy of dose calculation for ISOgray TPS in the presence of a wedges in the treatment fields. Materials and Methods: GATE (Geant4 Application for Tomography Emission) as a Monte Carlo (MC) code was utilized to model the 6 MV photon beam of an Elekta Compact linac. It did MC code verification for three different field sizes and three depths for open, and wedged fields with gamma index tool. Following the confirmation, the percentage depth dose (PDD) and dose profile were calculated using the TPS and compared with the simulation results. In the next step, the TPS dose calculations for the 10×10cm2 field with different wedge angles were compared by the result from analytical formula. Results: The PDD and dose profiles for open fields met the gamma index criteria. However, there was disagreement for large wedged fields. The dose profiles of wedge angles using Petti analytical equation were compared to ISOgray dose profiles. Results showed that dose profile points with all wedge angles meet the gamma index criteria except for the 45˚ wedge angle. Conclusions: The results indicated that the disagreement between MC and TPS dose calculations increases by increasing wedge angle and field size. The uncertainty is due to TPS dose calculation algorithm causing noticeable disagreement. A MC-based TPS for dose calculation is recommended to reduce the error in dose calculation or at least medical physicist consider this issue. IMRT, Effective wedge angle, motorized wedge, radiotherapy planning, ISOgray, Monte Carlo method. 303 308 http://ijrr.com/browse.php?a_code=A-10-1-1174&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/11 1403/2/22 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 S. Raghavi Medical Physics Department, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran 00319475328460026874 00319475328460026874 No H.R. Sadoughi Medical Physics and Radiology Department, Faculty of Paramedicine, North Khorasan University of Medical Sciences, Bojnurd, Iran 00319475328460026875 00319475328460026875 No M.E. Ravari Medical Physics Department, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran 00319475328460026876 00319475328460026876 No M.A. Tajik Mansoury Medical Physics Department, Shahid Beheshti University of Medical and Science, Tehran, Iran 00319475328460026877 00319475328460026877 No M. Behmadi Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran behmadim881.mph@gmail.com 00319475328460026878 00319475328460026878 No

en Background: To evaluate the effects of probe positioning on radioactive iodine uptake (RAIU) measurements and 131I quantification in Graves disease (GD) patients. Materials and Methods: We performed a cross-sectional study in GD patients between May 9 and June 27, 2013. 24 hr-RAIU was measured. Measurement A was the reference measurement and was obtained with the probe parallel to the bottom of the thyroid cartilage. Measurements B, C, D, and E were obtained by moving the probe 2.5 cm to the left, 5 cm to the left, 2.5 cm vertically upward, and 5 cm vertically upward, respectively. The 131I doses were calculated. Non-reference measurements were compared with measurement A using the paired t-test or Wilcoxon signed-rank test. Results: A total of 63 GD patients (17 men, 40.3±13.6 years old) were enrolled. Among them, 57 patients had 24 hr-RAIU measurement and 37 patients chose the 131I treatment. Significant changes were observed in 24 hr-RAIU and 131I dose between measurement A (24 hr-RAIU 60.40±12.67% and median 131I dose 8.17 mCi) and measurement E (24 hr-RAIU 48.67±11.74% and median 131I dose 9.50 mCi) (P<0.05). In one patient, the 24 hr-RAIU was 20.3% lower in measurement E compared with that in measurement A, resulting in a 30 mCi increase in the calculated 131I dose. Conclusions: The vertically upward movement by a distance of a radius of the collimator could affect the 24 hr-RAIU measurement and thus cause inaccurate calculation of the 131I dose. Thyroid function tests, iodine radioisotopes, Graves’ disease, data accuracy. 309 313 http://ijrr.com/browse.php?a_code=A-10-1-1175&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/12 1403/2/23 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 J. Zeng Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China 00319475328460026880 00319475328460026880 No T. Zhang Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China 00319475328460026881 00319475328460026881 No Y. Yang Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China 00319475328460026882 00319475328460026882 No J. Wang Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China 00319475328460026883 00319475328460026883 No X. Han Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China 00319475328460026884 00319475328460026884 No Q. Guo Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China 00319475328460026885 00319475328460026885 No Y. Fang Department of Endocrinology, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China fangyi5zhongxin@163.com 00319475328460026886 00319475328460026886 Yes

en Background: To evaluate the diagnostic potential of joint testing of serum tumor markers containing cytokeratin fragment antigen 21-1 (CYFRA21-1), progastrin-releasing peptide (ProGRP), carcinoembryonic antigen (CEA) as well as neuron-specific enolase (NSE) in a variety oflung cancer (LC). Materials and Methods: The LC group comprised 150 LC patients who were diagnosed for the first time and were not treated. During the same period, 120 patients harbored benign lung diseases and 120 healthy subjects were respectively designated as the benign group and control group. Immunochemiluminescence assay was implemented to detect tumor markers in serum from three groups and different types of LC. Results: Levels of four serum tumor markers in LC group were elevated relative to control group. CYFRA21-1 level in lung squamous cell carcinoma (LSCC) group was elevated compared to lung adenocarcinoma (LUAD) and small cell lung cancer (SCLC) groups. ProGRP and NSE levels in SCLC group increased compared to LSCC and LUAD groups. CEA level in LUAD group was higher compared to LSCC and SCLC groups. The highest positive rate of LSCC was CYFRA21-1, the highest positive rate of LUAD was CEA and the highest positive rates of SCLC were ProGRP and NSE. In terms of single tumor marker detection, CYFRA21-1 possessed the best diagnostic efficiency for LSCC, CEA possessed the best diagnostic efficiency for LUAD, NSE and ProGRP possessed the best diagnostic efficiency for SCLC, respectively. Conclusion: The individual determination of CYFRA21-1, ProGRP, CEA, and NSE has certain clinical application value for the pathological classification of LC. Lung cancer, tumor markers, diagnosis. 315 319 http://ijrr.com/browse.php?a_code=A-10-1-1176&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/12 1403/2/23 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 W. Liu Department of Clinical Laboratory, Beijing Hospital of Integrated Chinese & Western Medicine, Beijing 100039, China 00319475328460026888 00319475328460026888 No D. Zang Department of Clinical Laboratory, Beijing Hospital of Integrated Chinese & Western Medicine, Beijing 100039, China lww16032810@163.com 00319475328460026889 00319475328460026889 Yes

en Background: To study the possible dosimetric benefits of a Hybrid planning technique that consists of combining intensity modulated radiotherapy (IMRT) and volumetric arc therapy (VMAT) for whole brain radiation therapy hippocampal-sparing (WBRT-HS). Materials and Methods: Three types of plans were made for 15 patients, namely Hybrid, pure IMRT, and pure VMAT and retrospectively compared. Each plan was made using contoured structures on computed tomographic (CT) images fused with magnetic resonance imaging (MRI). The homogeneity (HI) and conformity (CI) indices of the planning target volumes (PTVs) were calculated to establish the dosimetric quality in all plans. The dose received to organs at risk (OARs), number of monitor units (MUs) and treatment time were evaluated for each type of planning technique. Results: Hybrid plans showed superior homogeneity (p = 0.04) and conformity (p = 0.01) indices compared to IMRT and VMAT plans. In terms of hippocampus sparing, the Hybrid technique showed almost equal D100% and maximum dose (Dmax) values compared to the other techniques, but without statistical significance (p> 0.05); however, there was a significant difference for the left hippocampus, where the IMRT technique obtained the best result (p <0.001). Hybrid plan values for dose delivered to the remaining OARs, MUs and treatment times were intermediate between those of IMRT and VMAT. Conclusion: Compared to the IMRT and VMAT plans, the hybrid plan showed improved dosimetric plan quality along with intermediate dose values to the OARs. Brain neoplasms, hippocampus, radiotherapy, intensity-modulated. 321 328 http://ijrr.com/browse.php?a_code=A-10-1-1177&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/12 1403/2/23 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 E.A. Martín-Tovar División de Oncología y Uronefrología, Departamento de Radioterapia, Unidad Médica de Alta Especialidad, Hospital de Especialidades del Centro Médico Nacional “Ignacio García Téllez”, Instituto Mexicano del Seguro Social, CP 97150, Mérida Yucatán, México enrique.martin.tovar@gmail.com 00319475328460026902 00319475328460026902 Yes A.H. Badillo-Alvarado División de Oncología y Uronefrología, Departamento de Radioterapia, Unidad Médica de Alta Especialidad, Hospital de Especialidades del Centro Médico Nacional “Ignacio García Téllez”, Instituto Mexicano del Seguro Social, CP 97150, Mérida Yucatán, México 00319475328460026903 00319475328460026903 No L.E. Cocom-Poot División de Oncología y Uronefrología, Departamento de Radioterapia, Unidad Médica de Alta Especialidad, Hospital de Especialidades del Centro Médico Nacional “Ignacio García Téllez”, Instituto Mexicano del Seguro Social, CP 97150, Mérida Yucatán, México 00319475328460026904 00319475328460026904 No J.L. Gaxiola-Sosa División de Oncología y Uronefrología, Departamento de Radioterapia, Unidad Médica de Alta Especialidad, Hospital de Especialidades del Centro Médico Nacional “Ignacio García Téllez”, Instituto Mexicano del Seguro Social, CP 97150, Mérida Yucatán, México 00319475328460026905 00319475328460026905 No

en Background: Wireless Fidelity (Wi-Fi) exposure might induce tissue damage through non-thermal effects. Nonetheless, only a few studies have evaluated the non-thermal effects on the testis undergoing reproductive development following Wi-Fi exposure. This study aimed to assess the oxidative stress status in the testis and subsequent sperm quality of growing rat pups that received edible bird nest (EBN) supplementation simultaneously. Materials and Methods: Fourteen weeks of 2. 45GHz Wi-Fi exposure and simultaneous 250mg/kg EBN were supplemented to three-week-old male Sprague–Dawley rats. Thirty animals were divided equally into control, control EBN, Wi-Fi, sham Wi-Fi, and Wi-Fi+EBN. Results: Results showed an increase in total oxidant status (TOS), a significant decrease in total antioxidant status (TAS), and a significant increase in the expression of 8-hydroxy-2′-deoxyguanosine (8-OHdG) in the testis of the Wi-Fi group. Sperm chromatin integrity, morphology, concentration, and motility were among the parameters that significantly decreased. Supplementation of 250mg/kg EBN in the Wi-Fi+EBN group significantly reduced TOS and 8-OHdG expression in the testis. EBN supplementation also significantly increased sperm chromatin integrity, morphology, and concentration. Conclusion: Wi-Fi exposure induces oxidative stress in the testis and affects important sperm parameters in rat pups. EBN supplementation quenched the oxidative stress activity due to Wi-Fi exposure and improved sperm quality. IMRT, OARs, TPS, DVH, mixed energy plans. 329 338 http://ijrr.com/browse.php?a_code=A-10-1-1178&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/12 1403/2/23 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 F.H.F. Jaffar Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia 00319475328460026913 00319475328460026913 No K. Osman Forensic Science Program, Centre for Diagnostic Science & Applied Health, Faculty of Health Sciences, Universiti Kebangsaan Malaysia (UKM), UKM Bangi, Selangor 43600, Malaysia 00319475328460026914 00319475328460026914 No C.K. Hui Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia 00319475328460026915 00319475328460026915 No A.F. Zulkefli Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia 00319475328460026916 00319475328460026916 No S.F. Ibrahim Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia timi@ukm.edu.my 00319475328460026917 00319475328460026917 Yes

en Background: Both fractional anisotropy (FA) and mean kurtosis (MK) in diffusion kurtosis imaging (DKI) have value in the diagnosis of Parkinson’s disease (PD). We here investigated the sensitivity and specificity of FA and MK to explore which of these methods were more efficient in the early diagnosis of the PD rat model. Materials and Methods: Twenty male SD rats were injected with 6-OHDA into the right substantia nigra (SN) for modeling, and other 20 rats were included in control group. DKI was performed 5 weeks after modeling. The FA and MK values of the right SN were measured and analyzed. Receiver operating characteristic curve was used to evaluate the sensitivity and specificity of the above two value in the identifying PD. Immunohistochemistry of tyrosine hydroxylase (TH), Tunel assay, and Nissl staining in the SN was performed. Results: The FA, MK and FA+MK values in the PD group obtained on the 5th week were statistically significantly different from those of the control group (P < 0.01). The optimal cut-off FA+MK value (with respective area under the curve, sensitivity, specificity) was 1.404 (0.925, 95%, 75%), the Youden’s index of FA+MK was higher than of either of the two alone. The FA, MK and FA+MK values correlated positively with the Tunel staining, while they correlated negatively with the TH and Nissl staining. Conclusions: At the 5th week, the diagnostic efficiency of the combined FA and MK values was better than of either of the two alone in diagnosing PD. Fractional anisotropy, mean kurtosis, diffusion kurtosis imaging,Parkinson’s disease. 339 345 http://ijrr.com/browse.php?a_code=A-10-1-1179&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/12 1403/2/23 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 Y. Chen Department of Magnetic Resonance Imaging, First Hospital of Qinhuangdao, No. 258 Wenhua Road, Qinhuangdao, Hebei Province, PR China 00319475328460026919 00319475328460026919 No D. An Department of Magnetic Resonance Imaging, First Hospital of Qinhuangdao, No. 258 Wenhua Road, Qinhuangdao, Hebei Province, PR China 00319475328460026920 00319475328460026920 No Y. Dong Department of Interventional treatment, First Hospital of Qinhuangdao, No. 258 Wenhua Road, Qinhuangdao, Hebei Province, PR China dyc_hometown@aliyun.com 00319475328460026921 00319475328460026921 Yes

en Background: The goal of this study was to create a prediction model for brain metastasis (BrMs) in patients with lung cancer using unenhanced spectral computed tomography (CT) and radiomics. Materials and Methods: This study comprised 162 patients with lung cancer who underwent spectral CT from 2019–2021. Patients were split into training and test sets and into BrMs and BrMs-free groups. Spectral and radiomics parameters were obtained from the spectral CT images before pathological confirmation. Prediction models in the training and test sets were created using logistic regression. The receiver operating characteristic curve was used to evaluate each quantitative parameter for predicting BrMs. The diagnostic effectiveness of several parameters was analyzed and compared using the area under the curve (AUC) calculation. The final model was obtained using the Delong test. Results: There were statistically significant differences in the iodine concentrations and the slope of the energy spectrum attenuation curve of the two groups <(p0.05). The AUC of the combined radiomics model was greater than that of the 70 keV and 120 keV sequence models. The joint parameters of radiomics and spectral CT constructed an integrated model. In the training set, test set, and overall set, the AUCs of the integrated model were 0.875, 0.879, and 0.724, respectively. In the training and overall sets, the prediction performance of the integrated model outperformed the spectral and radiomics models (p<0.05). Conclusions: This integrated model may predict the BrMs in lung cancer patients. Prediction model, spectral CT, radiomics, lung cancer, brain metastasis. 347 353 http://ijrr.com/browse.php?a_code=A-10-1-1180&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/19 1403/2/30 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 S. Cao Department of Radiology, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai 200082, China cao906436987@163.com 00319475328460026953 00319475328460026953 Yes Z. Shu Department of Radiology, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai 200082, China 00319475328460026954 00319475328460026954 No

en Background: Using cone-beam computed tomography (CBCT) in radiotherapy, the thorax or pelvis, which are both large areas, can be scanned by rotating the gantry 360° using a half-fan (HF) bowtie filter (BF). The HF mode has a longer scan time than that of the full-fan (FF) mode, thus exposing the patient to an increased imaging dose. Materials and Methods: To determine the applicability of FF to anatomically large areas, positioning error values and absorbed dose of organs at risk (OARs) were measured when HF and FF were employed in 22 patients who underwent pelvic intensity-modulated radiation therapy. Results: In a clinical experiment applying FFBF scan mode to anatomically large areas of a patient’s body during CBCT, the positioning error values were measured for all target areas within the mean ± 3 mm in all three directions. The scanning time in the FF scan mode was reduced by 20 s, while the absorption dose was reduced by 7–52 times in the OARs. Conclusion: The appropriate application of FF for treating large-size targets can reduce the CBCT scanning time, which, in turn, would markedly decrease the radiation exposure in patients by reducing random errors during procedures. Bowtie filter, Full-fan, Half-fan, Positioning error values. 355 360 http://ijrr.com/browse.php?a_code=A-10-1-1182&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/19 1403/2/30 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 W.K. Choi Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea 00319475328460026964 00319475328460026964 No W. Park Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea 00319475328460026965 00319475328460026965 No S. Kim ksc@gachon.ac.kr 00319475328460026966 00319475328460026966 Yes

en Background: miR-144-3p exerts inhibitory roles in hepatocellular carcinoma (HCC). This paper aims to explore that miR-144-3p and its predictive target gene, SLIT- and NTRK-like family member 4 (SLITRK4), in HCC progression. Materials and Methods: The levels of SLITRK4 and miR-144-3p were determined by western blot and qPCR. A loss- and gain-of-function test was used to test whether the relationship between miR-144-3p and SlitrK4 affected the growth of HCC cells. StarBase examined the miR-144-3p target prediction using SLITRK4. Through the use of a luciferase reporter experiment, miR-144-3p's targeting SLITRK4 was identified. The salvage experiment confirmed that miR-144-3p interacts SLITRK4 to regulate the progression of HCC. Results: Findings showned that the expression of miR-144-3p decreased in HCC tissue and cells. MiR-144-3p inhibits deterioration progression of HCC cell progression. MiR-144-3p targeted SLITRK4 and negatively modulated SLITRK4 levels. Besides, miR-144-3p upregulation decreased HCC migration and invasion activity, while SLITRK4 overexpression reduced this inhibition effects. Conclusions: MiR-144-3p regulates invasion and proliferation activity in HCC by targeting SLITRK4. MiR-144-3P/ SLITRK4 axis might provide a potential anti-cancer therapy pathway for clinical diagnosis, treatment and prognosis in hepatoma. MiR-144-3p, SLITRK4, tumor progression, Hepatocellular carcinoma. 361 366 http://ijrr.com/browse.php?a_code=A-10-1-1181&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/19 1403/2/30 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 D.B. Xiao Department of Clinical Laboratory, SiJing Hospital of SongJiang District, Shanghai City, 201601, China 00319475328460026956 00319475328460026956 No H. Xu Department of Oncology, Ezhou Central Hospital, Ezhou City, Hubei Province, 436000, China 00319475328460026957 00319475328460026957 No J.C. Li Department of Clinical Laboratory, Hengyang Central Hospital, Hengyang City, Hunan Province, 421000, China 00319475328460026958 00319475328460026958 No K.K. Peng Department of Clinical Laboratory, SiJing Hospital of SongJiang District, Shanghai City, 201601, China 00319475328460026959 00319475328460026959 No X.L. Jiang Department of Clinical Laboratory, SiJing Hospital of SongJiang District, Shanghai City, 201601, China 00319475328460026960 00319475328460026960 No D.X. Wang Department of General Surgery, SiJing Hospital of SongJiang District, Shanghai City, 201601, China 00319475328460026961 00319475328460026961 No F.F. Zhu Department of Hepatobiliary and Pancreas Surgery, The First Affiliated Hospital of University of South China, Hengyang City, Hunan Province, 421001, China zff200078@163.com 00319475328460026962 00319475328460026962 Yes

en Background: Metal Artifact Reduction (MAR) is very important in terms of dose calculation and optimization accuracy in radiotherapy (RT). There are many MAR programs available commercially.  In this study, a MAR program was developed using MATLAB software (MATLAB-MAR), and the effect of the developed MATLAB-MAR on radiotherapy dose distribution was examined. Materials and Methods: In line with the purpose of the study, a phantom containing metal with a high atomic number (z=82) was created, and computer tomography (CT) of the phantom was taken. MAR developed with MATLAB software and a commercial metal artifact reduction (Smart-MAR) were applied on CT slices.  The Hounsfield unit (HU), visually, artefact size and gamma evaluation effects of MATLAB-MAR, Smart-MAR and Without-MAR slices in the CMS XiO planning systems. Results:  As a result of the study, the best visually and HU improvement was seen in MATLAB-MAR. Moreover, in the dose distribution evaluation made by gamma analysis, an improvement was observed in MATLAB-MAR. Conclusion: Although similar values were obtained with MATLAB-MAR and the commercial software, it was determined that MATLAB-MAR was more advantageous than the commercial software in terms of being cost-free, providing results in a shorter time, not requiring reconstruction, and being open to development. Metal artifact reduction, radiotherapy, gamma analysis, MATLAB. 367 372 http://ijrr.com/browse.php?a_code=A-10-1-1183&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/19 1403/2/30 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 A. Inal Department of Radiation Oncology, Health of Science University, Antalya Training and Research Hospital, Kazım Karabekir Street, Muratpaşa, Antalya, Turkey aysuntoy@yahoo.com 00319475328460026968 00319475328460026968 Yes S. Barlaz Us Department of Radiation Oncology, Mersin University School of Medicine Department, Çiftlikköy Kampüsü, Yenişehir, Mersin, Turkey 00319475328460026969 00319475328460026969 No

en Background: The research aims to construct a nomograph model for predicting distant metastasis of nasopharyngeal carcinoma after radiotherapy, and to evaluate the differentiation and consistency of the model. Materials and Methods: 292 nasopharyngeal carcinoma patients are selected and broken into a modeling group (204 cases) and a validation group (88 cases). The modeling group patients are further divided into a distant metastasis group (n=45) and a non-distant metastasis group (n=159). Logistic regression analysis is used to analyze the risk factors for distant metastasis of nasopharyngeal carcinoma after radiotherapy. Radiation therapy is performed on each group of patients and their lactate dehydrogenase, serum albumin, carcinoembryonic antigen are compared. Results: The proportion of age ≥ 60 years old, lymph node cystic invasion, laryngeal lymph node metastasis, T3-T4 staging, and N2-N3 staging in the distant metastasis group were higher than those in the non-distant metastasis group (P<0.05). Multiple logistic regression analysis denoted that age ≥ 60 years old, lymph node cystic invasion, laryngeal lymph node metastasis, T3-T4 stage, N2-N3 stage were risk factors for distant metastasis of nasopharyngeal carcinoma after radiotherapy (P<0.05). The Hosmer Limeshow goodness of fit test showed that the modeling group 2=5.489, P=0.601; Validation group 2=5.231, P=0.733. The areas under the receiver operating characteristic curves of the modeling group and the validation group were 0.828 and 0.822, respectively. Conclusion: The model constructed in this study for forecasting the risk of distant metastasis of nasopharyngeal carcinoma after radiotherapy has high prediction accuracy, good consistency, differentiation, and clinical applicability. Nasopharyngeal carcinoma, radiotherapy, distant metastasis, nomogram, prediction model. 373 378 http://ijrr.com/browse.php?a_code=A-10-1-1184&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/26 1403/3/6 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 Y. Fan Department of ENT, Shenzhen Shekou People's Hospital, Shenzhen, 518000, China 00319475328460027010 00319475328460027010 No M. Hui Department of ENT, Affiliated Hospital Of Guangdong Medical University, Zhenjiang, 524001, China Huiminglang@126.com 00319475328460027011 00319475328460027011 Yes F. Li Department of ENT, Affiliated Hospital Of Guangdong Medical University, Zhenjiang, 524001, China 00319475328460027012 00319475328460027012 No Y. Chen Department of ENT, Shenzhen Shekou People's Hospital, Shenzhen, 518000, China 00319475328460027013 00319475328460027013 No J. Liu Department of ENT, Shenzhen Shekou People's Hospital, Shenzhen, 518000, China 00319475328460027014 00319475328460027014 No C. Huang Department of ENT, Shenzhen Shekou People's Hospital, Shenzhen, 518000, China 00319475328460027015 00319475328460027015 No

en Background: The To investigate the feasibility, efficacy, and toxicity of three-dimensional conformal radiotherapy (3D-CRT) for treatment of patients with advanced hepatocellular carcinoma (HCC) complicated by portal vein tumor thrombosis (PVTT) and/or inferior vena cava tumor thrombosis (IVCTT). Materials and Methods: 53 HCC patients with PVTT/IVCTT undergoing 3D-CRT during the period from September 2008 to January 2014 were analyzed. The Kaplan-Meier method was used to analyze between-group differences in patient baseline information. Univariate and multivariate cox regression analyses were used to identify factors affecting survival in patients with HCC. Results: Computed tomography (CT) scan or MRI (Magnetic Resonance Imaging) of the upper abdomen one month post-radiotherapy showed an overall response rate (CR + PR) of 56.6% (30/53). Univariate analysis revealed that treatment regimen (P = 0.008), alpha fetoprotein (AFP) level (P = 0.012), response to radiotherapy, metastasis to celiac lymph nodes and site of tumor thrombosis were strongly associated with the prognosis of HCC patients with PVTT (P = 0.000). The median survival time was 9 months (95% CI: 7.43-10.57 months) in 23 (43.4%) PVTT patients, and 24 months (95% CI: 20.04-27.96 months) in 30 (56.6%) IVCTT patients. Multivariate Cox regression analysis revealed that metastasis to celiac lymph nodes (P = 0.004) and response to radiotherapy (P = 0.001) were independent factors affecting patients’ survival. Conclusion: 3D-CRT has high efficacy for treating HCC patients with PVTT, and metastasis to celiac lymph nodes and response to radiotherapy are primary factors affecting HCC patients’ survival. Hepatocellular carcinoma, Portal vein tumor thrombosis, Inferior vena cava, Three-dimensional conformal radiotherapy, Clinical efficacy. 379 385 http://ijrr.com/browse.php?a_code=A-10-1-1185&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/26 1403/3/6 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 Q. Tian Department of Radiation Oncology, Shangdong Provincial Third Hospital, Jinan Shandong 250031, P.R. China. 00319475328460027769 00319475328460027769 No L. Li Department of Radiation Oncology, Shangdong Provincial Third Hospital, Jinan Shandong 250031, P.R. China. 00319475328460027770 00319475328460027770 No F. Zhang Department of Gastroenterology, Shandong Second Provincial General Hospital, Jinan Shandong, 250000, P.R. China 00319475328460027771 00319475328460027771 No X. Wu Department of Radiation Oncology, Shangdong Provincial Third Hospital, Jinan Shandong 250031, P.R. China. wywx7606@163.com 00319475328460027772 00319475328460027772 Yes

en Background: This paper aimed to investigate the radiation dosimetry and dose deposition to the surrounded organs at risk (OARs) with different radial and longitudinal margins based on the normal tissue complication probability (NTCP) and dose-volume histogram (DVH) methods. Materials and Methods: Fifteen patients with histologically diagnosed esophageal cancer were retrospectively selected. From the clinical target volume (CTV), eight planning target volumes (PTV) were expanded for each patient, with one group of four radial margins (3mm, 5mm, 7mm, 10mm) and the other group of four longitudinal margins (3mm, 5mm, 7mm, 10mm). Then, eight plans with the prescription dose of 50.4Gy were designed in the tomotherapy system. Within each group, doses for the OARs and NTCP-based risk of pneumonitis and pericardial disease were compared. Results: Almost all the dose parameters in both groups, except for the Dmax (maximum dose) of the spinal cord in the longitudinal direction, showed significant linearly increasing trends with the expansion of margins. For same dose parameters, the increased slopes in the radial direction were larger than those in the longitudinal. Heart V30Gy (the percent volume of receiving 30Gy) grew fastest compared to other clinical constraint indexes in both groups, and the most significant difference in the risk of pneumonitis was observed in the radial group when the margin was expanded from 3 to 10mm. Conclusions: In order to lower the likelihood of radiation-related toxicity, radial margin expansion should be more strictly controlled in the radiotherapy of esophageal cancer with tomotherapy. Esophageal cancer, tomotherapy, margins, radiation dosimetry. 387 393 http://ijrr.com/browse.php?a_code=A-10-1-1186&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/262024/05/26 1403/3/6 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 X. Tian Department Radiation Oncology, Chongqing University Cancer Hospital, Chongqing, China 00319475328460027773 00319475328460027773 No Z. Shen Department Radiation Oncology, Chongqing University Cancer Hospital, Chongqing, China 00319475328460027774 00319475328460027774 No S. Wang Department Radiation Oncology, Chongqing University Cancer Hospital, Chongqing, China 00319475328460027775 00319475328460027775 No X. Liu Department Radiation Oncology, Chongqing University Cancer Hospital, Chongqing, China 00319475328460027776 00319475328460027776 No H. Luo Department Radiation Oncology, Chongqing University Cancer Hospital, Chongqing, China 00319475328460027777 00319475328460027777 No F. Jin Department Radiation Oncology, Chongqing University Cancer Hospital, Chongqing, China jfazj@126.com 00319475328460027778 00319475328460027778 Yes

en Background: To investigate the accuracy of diffusion-weighted imaging (DWI) in the differentiation between medulloblastoma and ependymoma tumors. Materials and Methods: A retrospectively analytical study was used. Eighty-nine patients with medulloblastoma and ependymoma tumors were included, as proved by the histopathological findings (2016–2019), and their ages ranged from 1 month to 15 years old. All DWI data were transferred through RadiAnt Dicom viewer and apparent diffusion coefficient (ADC) value calculations. Statistical analyses were conducted utilizing statistical software (MedCalc, version 19.0.4).  Results: The value of ADCmean was the significant ADC value that distinguished medulloblastoma from ependymoma. The value of ADCmean was inversely proportional to tumor grades. The ADCmean value at the ependymoma tumor was 1.141±0.293 mm2/s, whereas the ADCmean value at medulloblastoma tumor was 0.661± 0.123 mm2/s. Spearman’s correlation shows a significant negative correlation, and ADCmean (r = -0.72, P-value = 0.0001). The ADCmean has confirmed the highest diagnostic accuracy with an area under the curve (AUC) of 0.984 in cases in reference to histopathological findings as a gold standard and detects medulloblastomas and ependymomas tumors with sensitivity (96.92%), specificity (95.83%), PPV (98.4%,), NPV (92%) and accuracy (92.7%). There is a high level of agreement between the results of ADC value and histopathological findings, which is excellent agreement between the two tests as Kappa =0.915. ADCmean could serve as a base to distinguish medulloblastoma from ependymoma tumors with high accuracy. Conclusion: Using ADC map value to diagnose pediatric tumors could provide reliable and objective evidence for pre-operative differentiation. Diffusion-weighted imaging, medulloblastoma, ependymoma. 395 401 http://ijrr.com/browse.php?a_code=A-10-1-1187&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/262024/05/262024/05/27 1403/3/7 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 K.M. Abushab Medical Imaging Department, Applied Medical Sciences Faculty, Al Azhar University-Gaza, Palestinian Territory 00319475328460027779 00319475328460027779 No S. Abu-Laila Radiology Department, Al-Aqsa Hospital, Ministry of Health, Darussalam, Tanzania 00319475328460027780 00319475328460027780 No M. Tabash Medical Imaging Department, Applied Medical Sciences Faculty, Al Azhar University-Gaza, Palestinian Territory 00319475328460027781 00319475328460027781 No K. Quffa Medical Imaging Department, Applied Medical Sciences Faculty, Al Azhar University-Gaza, Palestinian Territory 00319475328460027782 00319475328460027782 No A. Shaltout Radiology Department, Al-Aqsa Hospital, Ministry of Health, Darussalam, Tanzania 00319475328460027783 00319475328460027783 No Y.S. Alajerami Medical Imaging Department, Applied Medical Sciences Faculty, Al Azhar University-Gaza, Palestinian Territory yasser_ajr@hotmail.com 00319475328460027784 00319475328460027784 Yes H.H. Mansour Medical Imaging Department, Applied Medical Sciences Faculty, Al Azhar University-Gaza, Palestinian Territory 00319475328460027785 00319475328460027785 No H. Beituni Medical Imaging Department, Health Sciences Faculty, HCT, UAE 00319475328460027786 00319475328460027786 No

en Background: In this experiment, we intend to investigate the relationship between ER-α36 expression and endometrial cancer. Materials and Method: A total of 172 healthy control and endometriosis patients were selected from our hospital. These included 43 cases of normal endometrium (NE group), 43 cases of endometrium without atypical hyperplasia (EH group), 43 cases of atypical hyperplasia (AH group) and 43 cases of endometrial cancer (EC group). The expression of ER-α36 in these tissues was detected by immunohistochemical methods. Results: The positive rate of estrogen receptor (ER-α36) in each group was 4.24%±5.02%, 5.74%±6.34%, 9.69%±9.42%, and 11.78%±10.39%, respectively. The expression of ER-α36 demonstrated a notably higher level in the AH and EC groups compared to the EH and NE groups. A statistically significant difference was observed between the NE group and the AH group (P=0.0112). The NE group was statistically different from the EC group (P=0.0001).There was a statistical difference between the EH group and the EC group (P=0.0040). Among endometrial cancers, the mean positive rate of ER-α36 expression was 11.67%±6.74% in highly differentiated endometrial cancers, 9.45%±11.38% in moderately differentiated, and 14.82%±11.35% in poorly differentiated. Comparison between the two groups showed that there was no statistically significant difference in the expression positivity rate of ER-α36 in endometrial cancer of different degrees of differentiation (P>0.05). Conclusion: ER-α36 has a certain diagnostic efficacy for endometrial cancer and can be used as an auxiliary judgment tool for pathological examination. ER-α36, diagnosis, endometrium cancer. 403 409 http://ijrr.com/browse.php?a_code=A-10-1-1188&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/262024/05/262024/05/272024/05/27 1403/3/7 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 F. Li The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050000, China 13472192605@163.com 00319475328460027787 00319475328460027787 Yes L. Li The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China 00319475328460027788 00319475328460027788 No H. Li The Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050000, China 00319475328460027789 00319475328460027789 No

en Background: This investigation elucidates the significance of radiation emergency medicine (REM) within South Korea, while addressing the multifaceted challenges linked to the education of medical personnel in the field of radiation emergency responses. The efficacy of REM training initiatives has undergone scrupulous evaluation through a variety of techniques, including, but not limited to, the application of the DISASTER Paradigm and engagement in simulation-based training exercises. Materials and Methods: The present research is structured to evaluate the incremental utility of REM training programs by applying the Difference-in-Difference (DID) estimation using OLS regression methodologies. Simultaneously, it aims to suggest potential improvements to existing training modules. Central to the methodology is the estimation of the DID model via the 'sm.ols' function in the Python programming environment. In the equation 'outcome ~ T_d + P_t + T_d * P_t', 'outcome' denotes the dependent variable under review, 'T_d' signifies the treatment dummy variable, and 'P_t' represents the period dummy variable. The interaction term 'T_d * P_t' elucidates the average effect of the treatment post-intervention, taking into account the temporal trend. Results: The conclusions drawn from this scholarly investigation have manifested negative net utilities across the three pivotal DISASTER Paradigm indicators (T, E, and R). Through the adept implementation of a Python-infused computational methodology, this study has yielded results characterized by precision and veracity. These insights furnish empirical evidence, indicating that the intervention in question may not have yielded an enhancement in the net utility for the designated target cohort. Conclusion: This scholarly inquiry underscores the efficacy and meticulous precision of OLS-DiD estimations executed via a Python-centric computational approach. The empirical findings emanating from this research serve to fortify a robust foundation for the strategic navigation of unique challenges within the intersecting realms of nuclear science and medical studies, with particular emphasis on advancing the field of radiation emergency medicine (REM) education. Radiation emergency medicine, training programs, difference-in-difference analysis, computational social science. 411 417 http://ijrr.com/browse.php?a_code=A-10-1-1189&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/262024/05/262024/05/272024/05/272024/05/29 1403/3/9 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 Seokki Cha Senior Researcher in R;D Strategy Center of Korea Institute of Science and Technology Information (KISTI), Seoul, South Korea sc04@kisti.re.kr 00319475328460027790 00319475328460027790 Yes

en Background: This research was conducted to compare dosiomics features extracted from planning target volume (PTV) between the two three-dimensional conformal radiation therapy (3D-CRT) and helical tomotherapy (HT) techniques in nasopharyngeal cancer. Materials and Methods: 3D-CRT plans were designed for ten nasopharyngeal patients previously treated with HT. For both treatment techniques, the total prescription dose was 70 Gray in 33 fractions. At first, the dosimetric parameters, including mean dose, conformity index (CI), and homogeneity index (HI), were calculated for two techniques. Then, using 3D-Slicer software, dosiomics features were extracted from the dose matrix of PTV. Results: In comparing the plans regarding dosimetric parameters, HT plans had a lower mean dose and higher CI (p-value <0.01 and <0.001, respectively). HI had no statistically difference between the two groups (p>0.9). Among 93 features extracted from PTV70, only 40 features including eight features from the first-order group, ten features from the gray-level co-occurrence matrix group (GLCM), seven features from the gray-level dependence matrix group (GLDM), ten features from the gray-level run-length matrix group (GLRLM), four features from the gray-level size-zone matrix group (GLSZM), and one feature from the neighboring gray-tone difference matrix group (NGTDM) were found to be significantly different between the two groups. Conclusion: According to the results, the dosiomics features can distinguish the differences between dose distributions in different studied plans. However, more studies should be done in selecting the most suitable features for use in evaluating the quality of the treatment plans. Radiotherapy, intensity-modulated, radiotherapy, conformal, nasopharyngeal neoplasms. 419 425 http://ijrr.com/browse.php?a_code=A-10-1-1190&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/262024/05/262024/05/272024/05/272024/05/292024/05/29 1403/3/9 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 M. Mirzaeiyan Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 00319475328460027791 00319475328460027791 No N. Najafizadeh Department of Radiotherapy Oncology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 00319475328460027792 00319475328460027792 No M. Saeb Department of Radiation Oncology, Seyed Alshohada Hospital, Isfahan, Iran 00319475328460027793 00319475328460027793 No D. Shahbazi-Gahrouei Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran shahbazi@med.mui.ac.ir 00319475328460027794 00319475328460027794 Yes

en Background: In this work, we investigated the effect of adding 0.3% w/w of the non-toxic substance agarose to the dosimeter formulation of genipin radiochromic gel, which was named LCA-GENA (Low Concentration Agarose-GENipin and Agarose) gel dosimeter.  Materials and Methods: A compact linear accelerator with a beam quality of 6 MV and a dose rate of  200 cGy/min irradiated the produced gel dosimeters in a dose range of 0-10 Gy. A UV-Visible spectrophotometer was used to read out the irradiated gel dosimeters. Calibration curves for both absorbance peak and area-under-spectrum responses were investigated. Furthermore, the physical and radiological characteristics of the new formulation were investigated. Results: The results showed that the dose sensitivity of the LCA-GENA gel dosimeter under the irradiated conditions is (8.4 ± 0.15) × 10-3 cm-1 Gy-1. Results showed adding the abovementioned percentage of agarose will increase the melting point of the genipin gel dosimeter from 24°C to 28°C. Also, an investigation of the radiological properties of the novel formulation revealed that this radiochromic gel is water equivalent. Conclusion: From the obtained results, it is verified that adding 0.3% w/w agarose to the genipin gel dosimeter leads to an increase in the melting point of the original genipin gel dosimeter, easier fabrication, and lower price than that of higher agarose concentrations. The mentioned features make this gel suitable for dosimetry applications in clinical and radiotherapy environments. Radiochromic gel dosimeter, dose sensitivity, GENA, radiological properties. 427 433 http://ijrr.com/browse.php?a_code=A-10-1-1191&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/262024/05/262024/05/272024/05/272024/05/292024/05/292024/05/29 1403/3/9 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 S.M.M. Abtahi Physics Department, Imam Khomeini International University, Qazvin, Iran sm.abtahi@sci.ikiu.ac.ir 00319475328460027795 00319475328460027795 Yes F. Bahrami Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran 00319475328460027796 00319475328460027796 No D. Sardari Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran 00319475328460027797 00319475328460027797 No

en Background: Clinical stage and the ability to achieve comprehensive treatment were the prognostic features of thymoma. In the present study, we aimed to analyze the efficacy of different types of therapy in patients with Masaoka-Koga stage III thymoma. Materials and Methods: From 2001 to 2018, patients newly diagnosed with thymoma was retrospectively analyzed. The c2test was used to evaluate patient characteristics, the Kaplan-Meier method was used to calculate overall survival (OS), log-rank method was applied to examine the difference between groups, and Cox regression was used to analysis the potential prognostic factors of OS. Results: The median follow-up time was 50 months (range: 3-221 months), and median OS was 51 (range: 3-221) months. The radical surgery group had a significantly better OS than the palliative surgery group. The 5- year, 10-year OS were 88.2%, 74.4% in the radical surgery group, whereas the 5- year, 10-year OS were 51.8% and 32.4% in the palliative group. The 5-year OS in surgery followed by adjuvant radiotherapy group was higher than that of surgery alone group (82.8% vs 55.8%, P=0.033); similarly, the 10-year OS of the two groups were 64.2% and, 50.2%, respectively (P＜0.05). Multivariate analysis revealed that age < 50 years (HR [hazard ratio]: 0.264), radical resection (HR:0.134, P=0.000), and surgery combined with radiotherapy (HR:2.778, P=0.009) were independently associated with better OS. Conclusion: In Masaoka-Koga stage III thymoma, patients treated with radical surgery was capable of achieving better OS than patients treated with palliative surgery. Moreover, radical surgery was an independent factor of prognosis. Thymoma, surgery, radiotherapy, overall survival, prognosis. 435 441 http://ijrr.com/browse.php?a_code=A-10-1-1192&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/262024/05/262024/05/272024/05/272024/05/292024/05/292024/05/292024/06/8 1403/3/19 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 Z. Song Department of Oncology, The First People’s Hospital of Lianyungang, Lianyungang, China 00319475328460027798 00319475328460027798 No M. Zhuang Department of Oncology, The First People’s Hospital of Lianyungang, Lianyungang, China 00319475328460027799 00319475328460027799 No Z. Jin Department of Oncology, The First People’s Hospital of Lianyungang, Lianyungang, China 00319475328460027800 00319475328460027800 No Y. Gao Department of Oncology, The First People’s Hospital of Lianyungang, Lianyungang, China 00319475328460027801 00319475328460027801 No B. Bian Department of Oncology, The First People’s Hospital of Lianyungang, Lianyungang, China bbx5720620@sina.cn 00319475328460027802 00319475328460027802 Yes

en Background: MicroRNAs (miRNAs) have crucial roles in human cancers. Many studies have certified that miRNAs are implicated in tumor progression via exosomes. Nevertheless, whether miRNA-339 is derived by exosomes and its effects in gastric cancer (GC) presents obscure. Therefore, our study attempted to clarify the functional role and molecular mechanism of miRNA-339 in GC. Materials and Methods: In this research, the potential of miRNA-339 in GC was verified through miRNA-339 elevation with cell function assays. Bioinformatics analysis together with mechanical assay was implemented for assessing the regulatory relation between miRNA-339 and zinc finger protein 689 (ZNF689). Moreover, the existence of exosomes was determined via transmission electron microscopy together with nanoparticle tracking analysis. Results: miRNA-339 presented significant down-regulation in GC. miRNA-339 elevation suppressed GC cell proliferation, invasion along with migration while elevated GC cell apoptosis. miRNA-339 targeted ZNF689 3’UTR to repress ZNF689 expression, thereby hindering GC progression. Finally, miRNA-339 was majorly incorporated into exosomes to hinder GC progression. Conclusion: In summary, exosome-delivered miRNA-339 may act to be a tumor repressor in GC by targeting ZNF689, which might be an underlying therapeutic target for GC. Gastric cancer, miRNA-339, ZNF689, exosome. 443 453 http://ijrr.com/browse.php?a_code=A-10-1-1193&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/262024/05/262024/05/272024/05/272024/05/292024/05/292024/05/292024/06/82024/06/9 1403/3/20 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 L. Liang Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241000, China 00319475328460028960 00319475328460028960 No Z. Zhang Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241000, China 00319475328460028961 00319475328460028961 No Z. Cheng Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241000, China 00319475328460028962 00319475328460028962 No H. Li Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241000, China 00319475328460028963 00319475328460028963 No H. Jiang Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241000, China jianghouxiang2023@163.com 00319475328460028964 00319475328460028964 Yes

en Background: The To measure regulatory T cells (Tregs) expression in driver-gene-negative advanced non-small cell lung cancer (NSCLC) as well as its effect on the therapeutic efficacy and prognosis of immune checkpoint inhibitors (ICIs). Materials and Methods: Fifty patients with advanced non-small cell lung cancer without driving genes who were receiving treatment with a monoclonal antibody targeting the programmed death receptor-1 (PD-1) made up the study group. 30 healthy subjects in the same period were chosen into the control group. Flow cytometry was used to identify CD4highCD25+Foxp3+Treg cells in peripheral blood of all participants. Relation between CD4highCD25+Foxp3+Treg cells and tumor markers were explored, and efficacy and prognosis in patients before and after therapy was analyzed. Results: The fraction of CD4highCD25+Foxp3+Treg cells in the study group was higher (P<0.05). Following three rounds of PD-1 monoclonal antibody treatment, patients' CD4highCD25+Foxp3+Treg cells proportion was lower than before treatment (P<0.01), and showed a positive correlation with tumor markers (P<0.05). The fraction of CD4highCD25+Foxp3+Treg cells in the CR+PR group decreased in both the second and third cycles after treatment compared to the SD+PD group (P<0.01), but no change was found before or during the first cycle (P>0.05). CD4highCD25+Foxp3+Treg cells proportion in the death group presented higher relative to the survival group (P<0.05). CD4highCD25+Foxp3+Treg cells predicted the area under the ROC curve was 0.8134, with significant difference (P<0.05). Conclusion: CD4highCD25+Foxp3+Treg cells proportion in peripheral blood of NSCLC patients shows increased, and has predictive value for therapeutic efficacy of ICIs and prognosis of driver-gene-negative advanced NSCLC patients. Non-small cell lung cancer, regulatory T cells, immune checkpoint inhibitors, prognosis. 455 461 http://ijrr.com/browse.php?a_code=A-10-1-1194&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/262024/05/262024/05/272024/05/272024/05/292024/05/292024/05/292024/06/82024/06/92024/06/10 1403/3/21 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 Y. Chen Department of Respiratory and Critical Care Medicine, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan 637000, China 13990829946@163.com 00319475328460027856 00319475328460027856 Yes S. Chen Department of Oncology, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan 637000, China 00319475328460027857 00319475328460027857 No Y. Li Department of Respiratory and Critical Care Medicine, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan 637000, China 00319475328460027858 00319475328460027858 No X. Guo Department of Pathology, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan 637000, China 00319475328460027859 00319475328460027859 No Q. Liang Department of Thoracic Surgery, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan 637000, China 00319475328460027860 00319475328460027860 No L. Yang Department of Respiratory and Critical Care Medicine, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan 637000, China 00319475328460027861 00319475328460027861 No C. Lei Department of Respiratory and Critical Care Medicine, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan 637000, China 00319475328460027862 00319475328460027862 No

en Background: Conventional treatments on osteosarcoma (OS) yield limited improvements in metastatic or relapsed cases, necessitating innovative therapeutic strategies. This study's objective is to reveal the role of long non-coding RNAs (lncRNAs) in prognosis and potential molecular pathways of OS. Materials and Methods: This study integrated bioinformatics, statistical analysis, and computational techniques to investigate m6A-related prognostic lncRNA clusters in OS. Consensus clustering and risk analysis were performed on the m6A-related prognostic lncRNAs. Nomogram model was built for survival prediction, and was assessed using survival time receiver operator characteristic (ROC) analysis and decision curves. A competitive endogenous RNA (ceRNA) network was built to explore lncRNA-miRNA (microRNA)-mRNA interactions using the microRNA database and metascape website, followed by functional enrichment analyses. Results: The analysis unveiled three distinct OS clusters, with Cluster 2 exhibiting the highest risk in the immune microenvironment. High risk 7-lncRNA signature demonstrated strong prognostic value in predicting OS overall survival. The ceRNA network highlighted complex interactions among mRNAs, miRNAs and lncRNAs. Functional enrichment analysis indicated that mRNAs within the ceRNA network were linked to many biological functions. Furthermore, 30 differentially expressed genes (DEGs) derived from low-risk and high-risk groups enriched in GO-BP connected to MAGE (melanoma antigen gene) family member A2 (MAGEA2) and MAGEA2B. These DEGs in high risk group were also upregulated in the three KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway. Conclusion: This study disclosed the role of high-risk m6A-associated lncRNAs in prognosis and potential molecular pathways of OS. These findings provided novel insights into OS pathogenesis and potential therapeutic targets, warranting further validation in clinical settings. osteosarcoma, long non-coding RNA (lncRNA), m6A modification, prognosis, chemoradiotherapy response, ceRNA network. 463 471 http://ijrr.com/browse.php?a_code=A-10-1-1195&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/262024/05/262024/05/272024/05/272024/05/292024/05/292024/05/292024/06/82024/06/92024/06/102024/06/10 1403/3/21 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 Y. Zhou Department of Anesthesiology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing, 100078, China 00319475328460028681 00319475328460028681 No Y. Bi Department of Orthopaedics, Shanghai Eighth People's Hospital, Jiangsu University, Shanghai 200235, China 00319475328460028682 00319475328460028682 No M. Wan Department of Orthopaedics, Shanghai Eighth People's Hospital, Jiangsu University, Shanghai 200235, China 00319475328460028683 00319475328460028683 No N. Xu Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China 00319475328460028684 00319475328460028684 No Y. Xu Department of Orthopaedics, Shanghai Eighth People's Hospital, Jiangsu University, Shanghai 200235, China 00319475328460028685 00319475328460028685 No P. Liu Department of Orthopaedics, Shanghai Eighth People's Hospital, Jiangsu University, Shanghai 200235, China 00319475328460028686 00319475328460028686 No H. Jiang Department of Orthopaedics, Shanghai Eighth People's Hospital, Jiangsu University, Shanghai 200235, China 00319475328460028687 00319475328460028687 No H. Fang Department of Orthopaedics, Shanghai Eighth People's Hospital, Jiangsu University, Shanghai 200235, China 00319475328460028688 00319475328460028688 No H. Hu Department of Orthopaedics, Shanghai Eighth People's Hospital, Jiangsu University, Shanghai 200235, China 00319475328460028689 00319475328460028689 No S. Xu Department of Orthopaedics, Shanghai Eighth People's Hospital, Jiangsu University, Shanghai 200235, China xusuyang 00319475328460028690 00319475328460028690 Yes S. Lan Department of Orthopaedics, Shanghai Eighth People's Hospital, Jiangsu University, Shanghai 200235, China lanshenghui_gk@163.com 00319475328460028691 00319475328460028691 No

en Background: Pelvic organ prolapse is a common gynecological condition affecting many women and impairing quality of life. Imaging modalities like 3D ultrasound can provide a valuable anatomical and morphological evaluation of pelvic floor support defects contributing to prolapse. Materials and Methods: This study evaluated the clinical utility of 3D transperineal pelvic floor ultrasound for assessing pelvic organ prolapse in women. Prolapse was quantified using the Pelvic Organ Prolapse Quantification (POP-Q) system based on ultrasound imaging. Additional ultrasound parameters measured were the levator hiatus area, levator ani muscle thickness, and hiatal balloon volume on Valsalva. Results: 3D ultrasound enabled comprehensive visualization and staging of pelvic organ prolapse. Significant stepwise differences were found between mild, moderate, and severe prolapse groups in the levator hiatus area, levator ani thickness, and balloon volume. Ultrasound measurements showed excellent reproducibility. Conclusion: 3D pelvic floor ultrasound allows accurate diagnosis and staging of pelvic organ prolapse severity. Quantified ultrasound indicators of levator injury and pelvic floor laxity correlate with prolapse grade. Our findings demonstrate that 3D ultrasound is a valuable imaging modality for comprehensive pelvic organ prolapse assessment in clinical practice. Pelvic organ prolapse, three-dimensional pelvic floor ultrasound, pelvic organ prolapse quantification, levator. 473 479 http://ijrr.com/browse.php?a_code=A-10-1-1196&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/262024/05/262024/05/272024/05/272024/05/292024/05/292024/05/292024/06/82024/06/92024/06/102024/06/102024/06/11 1403/3/22 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 Z. Wang Taizhou People's Hospital, Department of Gynecology and Obstetrics, Taizhou, Jiangsu, 225300, China 00319475328460027826 00319475328460027826 Yes Y. Chen Taizhou People's Hospital, Department of Gynecology and Obstetrics, Taizhou, Jiangsu, 225300, China 00319475328460027827 00319475328460027827 No A. Huang Taizhou People's Hospital, Department of Gynecology and Obstetrics, Taizhou, Jiangsu, 225300, China 00319475328460027828 00319475328460027828 No

en Background: To determine whether and how cinobufagin regulates hepatocellular carcinoma (HCC) cell proliferation and radioresistance. Materials and Methods: Radiosensitive (HepG2-NC) and radioresistant (HepG2-SR) HCC cells were treated with cinobufagin, X-ray ionizing radiation (IR) or a combination of cinobufagin and IR at different doses. Cell counting was performed using the Cell Counting Kit-8 assay. Key ferroptosis marker levels were determined using the indicated methods. RNA immunoprecipitation using an anti-m6A antibody followed by quantitative polymerase chain reaction was performed to determine the m6A levels in SLC7A11 mRNA. Results: Cinobufagin inhibited the proliferation of HepG2-NC and HepG2-SR cells. Exposure to X-rays decreased the HepG2-NC cell count in a time- and dose-dependent manner, but did not affect HepG2-SR cells. A low dose of cinobufagin did not change the cell count without IR exposure, but re-sensitized HepG2-SR cells to IR. The combination of low-dose cinobufagin and IR increased ferroptosis and decreased SLC7A11 expression levels. Mechanistically, the combination of a low dose of cinobufagin and IR decreased m6A levels in the 3' UTR of SLC7A11 in a METTL3-dependent manner. Conclusion: A low dose of cinobufagin exerted synergistic effects with IR and re-sensitized radioresistant HCC cells to IR via a METTL3/m6A-dependent pathway. Hepatocellular carcinoma, radioresistance, synergistic effect, ferroptosis, m6A methylation. 481 486 http://ijrr.com/browse.php?a_code=A-10-1-1197&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/262024/05/262024/05/272024/05/272024/05/292024/05/292024/05/292024/06/82024/06/92024/06/102024/06/102024/06/112024/06/16 1403/3/27 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 F. Ma Guangzhou University of Chinese Medicine, Guangzhou, 510006, China 00319475328460027829 00319475328460027829 No W. Zhang Guangzhou University of Chinese Medicine, Guangzhou, 510006, China 00319475328460027830 00319475328460027830 No X. Sun Department of Hepatobiliary Surgery, Linyi People’s Hospital, Linyi, 276003, China sunxjun2004@sina.com 00319475328460027831 00319475328460027831 Yes

en Background: One prevalent malignant tumor in the digestive system is gastric cancer (GC). Cortactin is an intracellular cytoskeleton protein and exerts the crucial function in GC development. However, the roles and mechanisms of cortactin in the invasion and metastasis of GC need further exploration. Materials and Methods: Cortactin expression in GC tissues and cells via western blot and quantitative reverse transcription PCR. Cell migration and invasion were detected by the Transwell assays. Immunofluorescence staining and extracellular matrix (ECM) degradation assays verified the ability to invadopodium formation and ECM degradation.We then used gelatin zymography to identify the relationship between cortactin and matrix metalloproteinases (MMPs). The xenograft tumor model proved that cortactin can accelerate tumor growth and intraperitoneal metastasis in mice. Results: We found that cortactin is overexpressed in GC. cortactin overexpression facilitated cell migration and invasion, whereas cortactin silencing exerted the opposite function. cortactin can facilitate invadopodium formation and ECM degradation in GC cells. Cortactin can positively regulate matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9) levels. Furthermore, Cortactin accelerate GC progression in vivo. Conclusion: In short, this study confirmed that cortactin enhanced invadopodium formation to accelerate GC development through upregulating MMP2 and MMP9. Gastric cancer, cortactin, invadopodium, metastasis, matrix metalloproteinases. 487 494 http://ijrr.com/browse.php?a_code=A-10-1-1198&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/262024/05/262024/05/272024/05/272024/05/292024/05/292024/05/292024/06/82024/06/92024/06/102024/06/102024/06/112024/06/162024/06/19 1403/3/30 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 Y. Wu Section for Gastrointestinal Surgery, Department of General Surgery, The Third People’s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, 610031, China 00319475328460027832 00319475328460027832 No M. Peng Department of Gastrointestinal surgery, The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, China 00319475328460027833 00319475328460027833 No Q. Tang Department of Emergency, The Third People's Hospital of Chengdu, Chengdu, Sichuan 610031, China 00319475328460027834 00319475328460027834 No P. Guo Section for Gastrointestinal Surgery, Department of General Surgery, The Third People’s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, 610031, China 00319475328460027835 00319475328460027835 No P. Nie Section for Gastrointestinal Surgery, Department of General Surgery, The Third People’s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, 610031, China 00319475328460027836 00319475328460027836 No Y. Cui Section for Gastrointestinal Surgery, Department of General Surgery, The Third People’s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, 610031, China 00319475328460027837 00319475328460027837 No J. Yu Center of Gastrointestinal and Minimally Invasive Surgery, Department of General Surgery, The Third People’s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University & The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, 610031, China dr_jiahuiyu@163.com 00319475328460027838 00319475328460027838 Yes

en While neonatal pneumothorax (NP) is uncommon, it presents a serious condition requiring immediate and precise diagnosis and treatment. To achieve this, dependence on imaging techniques is crucial for detecting gas accumulation within the infant's thoracic cavity. Traditionally, diagnosing NP relies heavily on Chest X-ray (CXR) examinations, involving ionizing radiation exposure, a persisting concern. Conversely, lung ultrasonography (LUS) has gained widespread recognition due to its convenience, expediency, and radiation-free attributes. The debate over whether LUS can completely replace traditional CXR remains contentious. Our objective is to conduct a thorough analysis of the efficacy of LUS and CXR examinations in diagnosing NP, with the intention of offering additional references for clinicians to optimize medical care for infants, minimizing radiation exposure and ensuring comprehensive protection of their health and safety. Neonatal pneumothorax, ultrasonography, mass chest X-ray, radiation. 495 500 http://ijrr.com/browse.php?a_code=A-10-1-1199&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/262024/05/262024/05/272024/05/272024/05/292024/05/292024/05/292024/06/82024/06/92024/06/102024/06/102024/06/112024/06/162024/06/192024/06/19 1403/3/30 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 H. Leng Department of Neonatology, Chongzhou People's Hospital, 611230, Chengdu, Sichuan, China Lenghuicz@163.com 00319475328460027839 00319475328460027839 Yes Y. Zhang Department of Neonatology, Chongzhou People's Hospital, 611230, Chengdu, Sichuan, China 00319475328460027840 00319475328460027840 No L. Zhang Department of Neonatology, Chongzhou People's Hospital, 611230, Chengdu, Sichuan, China 00319475328460027841 00319475328460027841 No Y. Liu Department of Neonatology, Chongzhou People's Hospital, 611230, Chengdu, Sichuan, China 00319475328460027842 00319475328460027842 No

en Background: The aim of this study was to evaluate the radiation dose effect of a low-dose chest computed tomography (CT) protocol implemented in our hospital during the outbreak of Coronavirus disease 2019 (COVID-19) by estimating lifetime attributable risk (LAR). Materials and Methods:  A total of 583 patients were randomly included in this study. The values of volumetric CT dose index (CTDIvol, mGy) and dose length product (DLP, mGy.cm) were extracted from CT console. CT-Expo is a CT dose software that was used to estimate effective dose (E) and organ doses. Lifetime attributed risk (LAR) of cancer incidence were calculated according to the Biological Effects of Ionizing Radiation (BEIR) VII report. Results: Of the 583 patients included in this study, 262 (44.9%) were men and 321 (55.1%) were women. The third quartile of CTDIvol and DLP were 2.5 mGy and 79.4 mGy.cm, respectively. The mean value of E was 1.1 ± 0.3 mSv, and it was statistically higher in females. Esophagus, lung and thymus received highest doses, and also in females breast received highest dose. The mean LAR of lung cancer was 5.3 per 100,000 patients, while the mean LAR of liver cancer was 0.1 per 100,000 patients. Conclusions: Despite the large number of chest CT scans during the Covid-19 era, the low-dose chest CT protocol implemented in our hospital caused low doses to organs and very low cancer risks. Tomography, X-Ray computed, Covid-19, lifetime risk, radiation exposure. 501 504 http://ijrr.com/browse.php?a_code=A-10-1-1200&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/262024/05/262024/05/272024/05/272024/05/292024/05/292024/05/292024/06/82024/06/92024/06/102024/06/102024/06/112024/06/162024/06/192024/06/192024/06/19 1403/3/30 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 F. Rasoulinejad Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran 00319475328460027843 00319475328460027843 No M. Keshtkar Medical Physics and Radiology Department, Faculty of Medicine, Infectious Diseases Research Center, Gonabad University of Medical Sciences, Gonabad, Iran Keshtkar.dmohammad@yahoo.com 00319475328460027844 00319475328460027844 Yes

en Background: The aim of this study was to elucidate the efficacy of atorvastatin calcium tablets to relieve morphine tolerance in cancer pain patients. Materials and Methods: Cancer patients were randomized into the control and observational groups. The morphine dose increment time (T2), the onset time of morphine (T1), the titration dose and pain management rate in the two groups were evaluated and compared. Adverse events such as nausea, vomiting, constipation and respiratory depression were recorded. The impact of different treatments on the life quality of patients was assessed with Karnofsky performance status (KPS) score. Liver function and hematologic toxicities of different treatment was evaluated and examined. Results: The duration of T2 was significantly prolonged in the observational group (P=0.04), while the time of T1 as well as the titration dose showed no significant difference between the two groups (P>0.05). The adverse effects were slighter in the observational group (P>0.05). There was no respiratory depression case in either group. The life quality in two groups of patients showed no difference (P>0.05). Liver function and hematologic toxicitie results indicated that the combined treatment showed no extra damage to liver function and had no severe haematologic toxicity compared with the control. Conclusion: The combined treatment of atorvastatin calcium tablets and morphine effectively prolonged the time between morphine dose increments, alleviating the morphine tolerance with high safety in cancer pain patients, which may provide clues for morphine tolerance treatment in cancer pain management. Morphine, Drug tolerance, atorvastatin calcium, cancer pain. 505 508 http://ijrr.com/browse.php?a_code=A-10-1-1201&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/262024/05/262024/05/272024/05/272024/05/292024/05/292024/05/292024/06/82024/06/92024/06/102024/06/102024/06/112024/06/162024/06/192024/06/192024/06/192024/06/19 1403/3/30 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 LF. Quan Department of Oncology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China 00319475328460027845 00319475328460027845 No J. Fan Department of Oncology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China fanjuan_edu@hotmail.com 00319475328460027846 00319475328460027846 Yes

en Background: To investigate the clinical efficacy of compound dexamethasone acetate cream coordinated with massage in the treatment of iodine contrast extravasation. Materials and Methods: There were sixty patients who were selected in total with iodine contrast extravasation transferred to our hospital from June 2020 to June 2021. With the adaption of the random number method, patients were split into observation group and control group, with 30 cases in each. Compound dexamethasone acetate cream coordinated with massage was applied to the observation group. Meanwhile, simple compound dexamethasone acetate cream was applied to the other group. The clinical efficacy, swelling and pain degree and complication rate of the two groups were compared. Results: The clinical effective rate of the former group (93.33%) was considerably higher than that of the latter (86.67%), the discrepancy was quite essential in statistics (P<0.05). Apart from that, the limb swelling value, redness and swelling resolution time and pain resolution time in the former group were considerably less than those in the latter one, which was with statistical essential (P<0.05). Besides, the incidence of complications in observation group (3.33%) was also considerably lower than that in control group (13.33%), and the two sets of data indicate the statistically significant difference (P<0.05) as well. Conclusion: Compound dexamethasone acetate cream combined with massage for the treatment of iodine contrast extravasation has definite clinical efficacy and high safety, which is able to considerably ameliorate the clinical symptoms of patients, which is worthy of widespread clinical application. Compound dexamethasone acetate cream, massage, iodine contrast extravasation. 509 513 http://ijrr.com/browse.php?a_code=A-10-1-1202&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/262024/05/262024/05/272024/05/272024/05/292024/05/292024/05/292024/06/82024/06/92024/06/102024/06/102024/06/112024/06/162024/06/192024/06/192024/06/192024/06/192024/06/19 1403/3/30 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 X.L. Xu Department of Radiology, Guangdong Provincial Hospital of Chinese Medicine, Guangdong, China 00319475328460027847 00319475328460027847 No R.L. Xie Department of Radiology, Guangdong Provincial Hospital of Chinese Medicine, Guangdong, China 00319475328460027848 00319475328460027848 No J.C. Chen Department of Radiology, Guangdong Provincial Hospital of Chinese Medicine, Guangdong, China 00319475328460027849 00319475328460027849 No Y.S. Ye Department of Radiology, Guangdong Provincial Hospital of Chinese Medicine, Guangdong, China ye7yong7song@163.com 00319475328460027850 00319475328460027850 Yes

en Background: This study investigates the efficacy of sonodynamic and low-dose radiation with methylene blue and gold nanoparticles coated with apigenin sonosensitizer on breast cancer cells. Method and Materials: HR-TEM, UV-visible, zeta-potential, FTIR, and DLS were used to confirm the synthesized gold nanoparticles coated with apigenin. The concentration of gold nanoparticles coated with apigenin and methylene blue was calculated, and then ultrasound and 2 Gy x-rays were used to irradiate them. Results: The results showed that sonodynamic therapy in combination with radiation at a concentration of 8 µg/ml nanoparticles and 0.4 µmol methylene blue had a significant effect on cell death (0.26± 0.02). Conclusion: This study highlights the potential of sonodynamic therapy as a non-ionizing and non-invasive treatment, as well as the possibility of eliminating the side effects of cancer treatment by using green nanoparticles rather than chemical sensitizers. Sonodynamic therapy, radiation, gold nanoparticles, Apigenin, methylene blue. 515 519 http://ijrr.com/browse.php?a_code=A-10-1-1203&slc_lang=en&sid=1 2024/04/172024/04/172024/04/172024/04/172024/04/302024/04/302024/04/302024/05/12024/05/112024/05/112024/05/122024/05/122024/05/122024/05/122024/05/122024/05/192024/05/192024/05/192024/05/192024/05/262024/05/262024/05/262024/05/272024/05/272024/05/292024/05/292024/05/292024/06/82024/06/92024/06/102024/06/102024/06/112024/06/162024/06/192024/06/192024/06/192024/06/192024/06/192024/06/19 1403/3/30 2024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/222024/04/22 1403/2/3 A. Neshastehriz Radiation Biology Research center, Iran University of Medical Sciences (IUMS), Tehran, Iran 00319475328460027851 00319475328460027851 No Z. Hormozi-Moghaddam Department of Radiation Sciences, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran Hormozimoghadam.z@iums.ac.ir 00319475328460027852 00319475328460027852 Yes S.M. Amini Department of Radiation Sciences, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran Amini.sm@iums.ac.ir 00319475328460027853 00319475328460027853 No S.M. Taheri Radiation Biology Research center, Iran University of Medical Sciences (IUMS), Tehran, Iran 00319475328460027854 00319475328460027854 No Z. Abedi Kichi Institute for cardiovascular prevention (IPEK), Ludwig-Maximilians University Munich, Germany 00319475328460027855 00319475328460027855 No