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:: Volume 21, Issue 3 (6-2023) ::
Int J Radiat Res 2023, 21(3): 361-367 Back to browse issues page
68-Ga-labeled NODAGA-RGD-BBN heterodimer peptide as a novel radiotracer for dual integrin and GRPR-targeted tumor imaging
N. Amraee, B. Alirezapour, M. Hosntalab, A. Hadadi, H. Yousefnia
Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran , balirezapour1358@gmail.com
Abstract:   (768 Views)
Background: Due to the excellent physical and biochemical characteristics of 68Ga, 68Ga-1,4,7-triazacy–clononane–glutaric acid– 4,7 acetic acid- arginyl-glycyl-aspartic acid- bombesin (68Ga-NODAGA-RGD-BBN) was prepared as a new positron emission tomography (PET) imaging agent, and afterward, the preclinical evaluation of this labeled peptide was studied. Materials and Methods: 68Ga radioisotope was extracted from a 68Ge/68Ga generator with high radionuclide, chemical and radiochemical purities. Then; the 68Ga-NODAGA-RGD-BBN radiolabeled complex was prepared at optimized conditions. The stability of the complex was evaluated in phosphate-buffered saline (PBS) for at least 2 h. Cell studies of the radiolabeled peptide were also assessed on the gastrin releasing peptide receptor (GRPR)-expressing cell line. Finally; the biodistribution and whole-body scan imaging study of 68Ga-NODAGA-RGD-BBN was studied in normal and tumor-bearing mice. Results: The biodistribution and whole-body scan imaging of the radiolabeled compound on GRPR-expressing tumor-bearing mice demonstrated the high uptake in the tumor site at all post-injection intervals.  The biodistribution results also demonstrated the major excretion route of the complex is the urinary tract. Conclusions: 68Ga-NODAGA-RGD-BBN shows high potential for PET imaging of patients with GRPR-expressing tumors; however, more biological studies are still needed.
Keywords: GRPR positive tumors, radiolabeling, heterodimer peptide, PET imaging.
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Type of Study: Original Research | Subject: Radiation Biology
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Amraee N, Alirezapour B, Hosntalab M, Hadadi A, Yousefnia H. 68-Ga-labeled NODAGA-RGD-BBN heterodimer peptide as a novel radiotracer for dual integrin and GRPR-targeted tumor imaging. Int J Radiat Res 2023; 21 (3) :361-367
URL: http://ijrr.com/article-1-4815-en.html

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Volume 21, Issue 3 (6-2023) Back to browse issues page
International Journal of Radiation Research
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