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:: Volume 22, Issue 2 (4-2024) ::
Int J Radiat Res 2024, 22(2): 381-387 Back to browse issues page
Dosimetric comparison of different radial and longitudinal margins for tomotherapy in esophageal cancer
X. Tian , Z. Shen , S. Wang , X. Liu , H. Luo , F. Jin
Department Radiation Oncology, Chongqing University Cancer Hospital, Chongqing, China , jfazj@126.com
Abstract:   (124 Views)
Background: This paper aimed to investigate the radiation dosimetry and dose deposition to the surrounded organs at risk (OARs) with different radial and longitudinal margins based on the normal tissue complication probability (NTCP) and dose-volume histogram (DVH) methods. Materials and Methods: Fifteen patients with histologically diagnosed esophageal cancer were retrospectively selected. From the clinical target volume (CTV), eight planning target volumes (PTV) were expanded for each patient, with one group of four radial margins (3mm, 5mm, 7mm, 10mm) and the other group of four longitudinal margins (3mm, 5mm, 7mm, 10mm). Then, eight plans with the prescription dose of 50.4Gy were designed in the tomotherapy system. Within each group, doses for the OARs and NTCP-based risk of pneumonitis and pericardial disease were compared. Results: Almost all the dose parameters in both groups, except for the Dmax (maximum dose) of the spinal cord in the longitudinal direction, showed significant linearly increasing trends with the expansion of margins. For same dose parameters, the increased slopes in the radial direction were larger than those in the longitudinal. Heart V30Gy (the percent volume of receiving 30Gy) grew fastest compared to other clinical constraint indexes in both groups, and the most significant difference in the risk of pneumonitis was observed in the radial group when the margin was expanded from 3 to 10mm. Conclusions: In order to lower the likelihood of radiation-related toxicity, radial margin expansion should be more strictly controlled in the radiotherapy of esophageal cancer with tomotherapy.
Keywords: Esophageal cancer, tomotherapy, margins, radiation dosimetry.
Full-Text [PDF 788 kb]   (35 Downloads)    
Type of Study: Original Research | Subject: Radiation Biology
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Tian X, Shen Z, Wang S, Liu X, Luo H, Jin F. Dosimetric comparison of different radial and longitudinal margins for tomotherapy in esophageal cancer. Int J Radiat Res 2024; 22 (2) :381-387
URL: http://ijrr.com/article-1-5444-en.html

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Volume 22, Issue 2 (4-2024) Back to browse issues page
International Journal of Radiation Research
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