International Journal of Radiation Research

en Values of multimodal magnetic resonance imaging (MRI) for identification and diagnosis of demyelinating pseudotumor (DPT) and glioma Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: This to research aims to evaluate values of conventional MRI and multimodal MRI for identification and diagnosis of tumor-like demyelinating lesions (TDL), also referred to as demyelinating pseudotumor (DPT), and glioma, with a focus on imaging-based differentiation between the two conditions. Materials and Methods: Conventional MRI sequences including T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), fluid-attenuated inversion recovery (FLAIR), and contrast-enhanced T1WI, as well as multimodal MRI sequences including diffusion-weighted imaging (DWI), susceptibility-weighted imaging (SWI), magnetic resonance spectroscopy (MRS), and dynamic susceptibility contrast MRI (DSC-MRI), were retrospectively analyzed in 61 patients with pathologically confirmed TDL and 66 patients with glioma. Results: On conventional MRI, glioma lesions were significantly larger than TDL lesions (mean diameter 41.3 mm vs. 24.4 mm, p<0.001), more frequently involved the cerebral cortex (80.3% vs. 31.1%), and exhibited greater perilesional edema and mass effect (p<0.001). TDL lesions more commonly demonstrated open-ring enhancement (54.1% vs. 19.7%, p<0.001) and a central vein sign on SWI (27.9% vs. 7.6%, p<0.05). MRS revealed significantly higher choline (Cho)/N-acetylaspartate (NAA) and Cho/creatine (Cr) ratios and lower NAA/Cr ratios in glioma compared to TDL (p<0.05). DSC-MRI demonstrated hyperperfusion in all examined glioma lesions (9/9) versus hypoperfusion in the majority of TDL lesions (7/8, p<0.001). Conclusion: The combination of conventional MRI and multimodal MRI sequences-particularly open-ring enhancement on contrast-enhanced T1WI, the central vein sign on SWI, metabolite ratios (Cho/NAA, Cho/Cr, NAA/Cr) on MRS, and perfusion patterns on DSC-MRI-provides significant discriminative value for differentiating TDL from glioma, and is superior to reliance on conventional MRI alone.</div> Demyelinating pseudotumor, tumor-like demyelinating lesions, glioma, magnetic resonance imaging, multimodal MRI. 1017 1021 http://ijrr.com/browse.php?a_code=A-10-1-1610&slc_lang=en&sid=1 Y. Chen 7900319475328460034874 7900319475328460034874 No Department of Radiology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, 363000, Fujian Province, China L. Wei 7900319475328460034875 7900319475328460034875 No Department of Radiology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, 363000, Fujian Province, China C. Zheng 7900319475328460034876 7900319475328460034876 No Department of Radiology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, 363000, Fujian Province, China S. Zhan 7900319475328460034877 7900319475328460034877 No Department of Radiology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, 363000, Fujian Province, China S. Chen 1574523258@qq.com 7900319475328460034878 7900319475328460034878 Yes Department of Human Anatomy, Fujian Medical University, Fuzhou,350000, Fujian Province, China X. Yang yangxiao1@pumch.cn 7900319475328460034879 7900319475328460034879 No Department of Ultrasound Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, 363000, Fujian Province, China