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:: Volume 13, Issue 3 (7-2015) ::
Int J Radiat Res 2015, 13(3): 205-212 Back to browse issues page
Concurrent chemoradiotherapy in locally advanced non-small cell lung cancer: a retrospective analysis of the correlation between radiotherapy-related factors and tumor response
Y.J. Park, W.S. Yoon Dr. , J.A. Lee, N.K. Lee, S. Lee, D.S. Yang, C.Y. Kim, J.H. Kim
Department of Internal Medicine, Ansan Hospital, Korea University Medical Center, Ansan, Republic of Korea , irionyws@naver.com
Abstract:   (5566 Views)

Background: To determine which radiotherapy parameters are associated with the tumor response of locally advanced non-small cell lung cancer (NSCLC) patients undergoing concurrent chemoradiotherapy. Materials and Methods: Thirty one patients with IIIA/IIIB NSCLC underwent chemoradiotherapy with a median dose of 63 Gy. On our actual treatments, we made radiotherapy planning to cover the planning target volume (PTV) with 95% of the prescribed dose, and checked the second CT simulation when a cumulative dose was about 36 Gy. For this study, each PTV of primary tumor was re-defined with even margins from the gross target volume (GTV), and the actual plan overlaid the re-defined PTV. The correlations between the tumor response rate during chemoradiotherapy and after chemoradiotherapy, and the dose distribution parameters (D95, V95, mean tumor dose and homogeneity index), total dose and GTV, were evaluated. Results: Median overall survival was 15.5 months and the two-year survival 42.3%. At first recurrence, radiation-field recurrence, distant metastases and simultaneous recurrence were developed in 35.5%, 41.9% and 9.7% of the cases, respectively. The dose distribution parameters were generally favorable and were not related with tumor response rate. The tumor response rate after chemoradiotherapy was correlated with the residual GTV at second simulation (&gamma=-0.627, p<0.001) and the tumor response rate during chemoradiotherapy (&gamma=0.541, p=0.003). Conclusion: Minimal correlation was found between the dose distribution parameters that were over the minimal dose requirement and tumor response in NSCLC with concurrent chemoradiotherapy. The small residual volume during chemoradiotherapy could indicate good tumor response after chemoradiotherapy.

Keywords: Non-small cell lung cancer, chemoradiotherapy, tumor response, Dose volume histogram, tumor volume
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Type of Study: Original Research | Subject: Radiation Biology
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Park Y, Yoon W, Lee J, Lee N, Lee S, Yang D, et al . Concurrent chemoradiotherapy in locally advanced non-small cell lung cancer: a retrospective analysis of the correlation between radiotherapy-related factors and tumor response. Int J Radiat Res. 2015; 13 (3) :205-212
URL: http://ijrr.com/article-1-1514-en.html


Volume 13, Issue 3 (7-2015) Back to browse issues page
International Journal of Radiation Research
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