Background: The present investigation compared the decrease in the volume of benign tumor before and after High Intensity Focused Ultrasound (HIFU) treatment to evaluate the therapeutic effects of HIFU. in terms of Lifestyle and obstetric characteristics of in patients with Benign Uterine Tumors. Materials and Methods: To collect the data on each patients’ lifestyle and obstetric characteristics, a survey was conducted on 55 patients with benign uterine tumors who had undergone HIFU treatment for three months. Results: Regarding obstetric characteristics, the longer the period of discontinuation of contraceptive pills, the higher the therapeutic effects of HIFU. Regarding lifestyle, the decrease in the benign tumor volume was more when the patient did not exercise during the treatment period, and was a non-smoker (p<0.05). Conclusion: The results of the present investigation may provide valuable basic data for increasing the understanding of the factors that heighten the therapeutic effects of HIFU, thereby contributing to the development of novel therapeutic strategies.