:: Volume 18, Issue 4 (10-2020) ::
Int J Radiat Res 2020, 18(4): 685-691 Back to browse issues page
Study of plasma homocysteine, folic acid and vitamin B-12 levels for radiation exposed transplanted solid Ehirlich tumors
A.A. Elhadary, E.A. Marzook, A.M. Kamal
Biological Application Dept., Nuclear Research center, Atomic Energy Authority, Cairo, Egypt , drebtisam@yahoo.com
Abstract:   (1375 Views)
Background: Alterations of systemic metabolic parameters are always present vitamins in cancer in addition radiotherapy may increases and complicates these disorders. The analysis of each biochemical metabolic alterations may give more understanding to biochemistry of malignancy   and improving the degree of radiotherapy. The current study aimed to follow up the changes of folate, vitamin B12 and homocysteine in normal and malignant mice with and without radiation exposure, as floate and B12 metabolism play a role in hypermethylation of certain genes including tumor suppressor and apoptotic genes of cancer. Materials and Methods: The study was conducted through six groups of mice, normal, malignant, normal and malignant exposed gamma radiation with different fractionated doses (0.7 and 1.2 Gy).
Results: Comparisons between the results of all groups revealed that: folate and vitamin B12 were lower and homocysteine was higher in gamma irradiated malignant and gamma irradiated nonmalignant mice in comparison with normal control and malignant mice. Folate and vitamin B12 levels were also lower whereas homocysteine was higher in malignant mice in comparison with normal control   group. Conclusion: These results denoted that increased homocysteine or/and decreased folate and vitamin B12 in the two malignant exposed groups may have a role in the primary tumor regression leading to the recommendation that preventing up taking of folate and vitamin B12 either as supplements of land nutrients rich with subsequent increase in homocystein may be beneficial through its toxic effect in stopping or minimizing tumor progression. The disturbance of vitamins may be due to the metabolic alterations associated with tumor development.
Keywords: Folic acid, homocystein, vitamin B-12, malignancy, radiotherapy
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Type of Study: Original Research | Subject: Medical Physics

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Volume 18, Issue 4 (10-2020) Back to browse issues page