Background: To explore the application of contrast-enhanced ultrasound and color Doppler ultrasonography in the treatment of primary hepatocellular carcinoma (PHC) after Transhepatic Artery Chemoembolization (TACE). Materials and Methods: 49 patients with primary hepatocellular carcinoma were treated with TACE for 3-5 times. Before and after treatment, digital subtraction angiography, contrast-enhanced ultrasound and color Doppler ultrasound were performed. The lesions before and after contrast-enhanced ultrasonography and color Doppler ultrasonography were compared. The residual or recurrence and swelling of lesions before and after contrast-enhanced ultrasonography and color Doppler ultrasonography were analyzed. Detection of the capsule of the lesion. Results: The detection accuracy of contrast-enhanced ultrasound (95.77%) was significantly higher than that of color Doppler ultrasound (84.51%) (P<0.05). The detection rate of tumor envelope by contrast-enhanced ultrasound (22.54%) was significantly higher than that by color Doppler ultrasound (9.86%) (P < 0.05). The accuracy of detecting residual or recurrent lesions by contrast-enhanced ultrasound (91.67%) was significantly higher than that by color Doppler ultrasound (58.33%) (P<0.05). Conclusion: The rate of bone metabolism of perimenopausal women in Xuzhou is not optimistic. We need to pay close attention to the risk of bone metabolism disorder of perimenopausal women with older age, diabetes mellitus and osteoporosis, so as to provide useful help for improving the quality of life of perimenopausal women in Xuzhou.