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:: Volume 20, Issue 1 (1-2022) ::
Int J Radiat Res 2022, 20(1): 151-156 Back to browse issues page
Estimation of human absorbed dose of 68-Ga-Citrate based on biodistribution data in rats: Comparison with 67-Ga-Citrate
F. Habibi, R. Faghihi, S. Zolghadri, H. Yousefnia, S. Sina, F. i Mohammadpour-Ghaz
Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran , hyousefnia@aeoi.org.ir
Abstract:   (791 Views)
Background: In recent years, Gallium-68 citrate has become known as an alternative radioisotope in nuclear medicine. As for its influences, 68Ga-based tracers have already been proposed as agents for positron emission tomography. In this research, the values of human absorbed dose for 68Ga-citrate and 67Ga-citrate were estimated using the medical internal radiation dose method based on biodistribution data in rats. Materials and Methods: 68Ga/67Ga-citrate was prepared from eluted 68Ga/67Ga-Cl3 ­and sodium citrate under multiple reaction forms. The biodistribution of 68Ga/67Ga–citrate radiolabeled compounds was investigated by dissection of five male rats at specific times after injection. The organs of the rats were removed and counted. Percentage of injected dose per gram was determined for each rat organ and the human absorbed dose was extrapolated using the rats’ data. Results: The results of estimating the human absorbed dose illustrate that 68Ga-citrate caused a much lower human absorbed dose compared with 67Ga-citrate. Conclusion: According to the results, it may be concluded that 68Ga-citrate, despite the better quality of PET imaging, is much safer in terms of absorption dose compared with 67Ga-­citrate, and from this point of view, it is a more appropriate agent for imaging applications.
 
Keywords: Internal radiation dose, MIRD, 68-Ga-citrate, 67-Ga-citrate.
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Type of Study: Original Research | Subject: Radiobiology
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Habibi F, Faghihi R, Zolghadri S, Yousefnia H, Sina S, Mohammadpour-Ghaz F I. Estimation of human absorbed dose of 68-Ga-Citrate based on biodistribution data in rats: Comparison with 67-Ga-Citrate. Int J Radiat Res. 2022; 20 (1) :151-156
URL: http://ijrr.com/article-1-4086-en.html


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Volume 20, Issue 1 (1-2022) Back to browse issues page
International Journal of Radiation Research
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