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The dosimetric and clinical comparison between helical tomotherapy and fixed-field intensity-modulated radiotherapy in radical irradiation for cervical cancer
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M.F. Guo   , X.J. Zhao , Y. Huang , D.K. Chen , N. Zhang |
| Department of Gynecologic Oncology, Chongqing University Cancer Hospital, Chongqing 400044, China , 18908370600@189.cn |
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Abstract: (1079 Views) |
Background: To compare the dosimetric parameters, clinical complications, and efficacy of helical tomotherapy (HT) and fixed-field intensity-modulated radiotherapy (f-IMRT) in radical radiotherapy for cervical cancer. Materials and Method: From November 2016 to December 2018, 77 cervical cancer patients in radical irradiation were selected, 38 patients undergoing treatment with HT and 39 with f-IMRT. The dosimetic parameters, clinical complications, and efficacy were compared. Results: The homogeneity index (HI) and conformity index (CI) of HT plans were both superior to those of f-IMRT plans(P=0.000). HT plans resulted in a reduction in the dosimetric parameters of organs at risk (OARs) (P<0.05) except the V10 of small intestine (P=0.682). The incidence of myelosuppression showed no significant differences (P=0.265).The patients with HT had no radiocystitis, grade 2 or above radiation proctitis. The complete remission (CR) rates, efficacy rates (CR+PR) and local control rates of two years were 81.58%,100% and 97.37%. Conclusion: HT showed advantages in dosimetry, and provided more superior clinical results. It has a good application prospect in radical irradiation for cervical cancer. |
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| Keywords: Cervical cancer, dosimetry, helical tomotherapy, intensity-modulated radiotherapy. |
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Full-Text [PDF 1617 kb]
(431 Downloads)
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Type of Study: Original Research |
Subject:
Radiation Biology
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