:: Volume 21, Issue 4 (10-2023) ::
Int J Radiat Res 2023, 21(4): 653-661 Back to browse issues page
Dose and irradiation time analysis of negative pi-meson therapy using particle and heavy ion transport code system (PHITS)
A.P. Muhammad , A.W. Harto , Y. Sardjono , G.S. Wijaya , Z. Ismail , I.M. Triatmok , Y. Kasesaz
Department of Nuclear Engineering and Engineering Physics, Faculty of Engineering, Universitas Gadjah Mada, 2 Grafika Street, Yogyakarta 55281, Indonesia , andhika.pinastika@mail.ugm.ac.id
Abstract:   (999 Views)
Background: Minimizing the radiation side effects in cancer therapy has become one of the major challenges in radiotherapy, especially if the cancer is located in vital organs such as the brain. Negative pi-meson-based therapy is one method of radiotherapy that allows cancer to receive a high radiation dose while the surrounding normal tissue receives a low radiation dose. This research aims to analyze negative pi-meson therapy's dose and irradiation time in glioblastoma multiforme. Material and Methods: Simulation-based research is conducted using the PHITS program. The source used is a negative pion beam with an intensity of 2.5 × 108 pions/second with an energy of 30 MeV to 60 MeV with an interval of 1 MeV. The negative pion energy, which has the maximum dose rate in the cancer target area, was optimized to obtain the weighting factors and irradiation time. The irradiation was carried out in 30 fractions with the dose per fraction of 2 Gy. Results: Irradiation time per fraction obtained was 194.91 seconds. The organ at risks (OARs) analyzed in this research were soft tissue, skin, brain, and cervical spinal cord. The doses received by the OAR are 0.2641 Gy, 0.7645 Gy, 7.3295 Gy, and 0.075 Gy, respectively. Conclusions: In summary, negative pi-meson therapy has the potential to minimize radiation dose to healthy tissue while cancer still receives high-dose radiation. However, it is necessary to compare negative pi-meson therapy and other radiotherapy methods to determine the strengths and weaknesses of each method.
Keywords: Dose, glioblastoma multiforme, irradiation time, negative pi-meson therapy.
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Type of Study: Original Research | Subject: Radiation Biology
References
1. 1. GLOBOCAN (2020) Estimated number of new cases in 2020. International Agency for Research on Cancer. https://gco.iarc.fr (accessed January 20, 2022).
2. Anonymous (2021) Glioblastoma Multiforme. American Association of Neurological Surgeons. https://www.aans.org/en/Patients/Neurosurgical-Conditions-and-Treatments/Glioblastoma-Multiforme (accessed January 20, 2022).
3. Salles D, Laviola G, Malinverni AC de M, Stávale JN (2020) Pilocytic Astrocytoma: A Review of General, Clinical, and Molecular Characteristics. J Child Neurol, 35: 852-8. [DOI:10.1177/0883073820937225] [PMID]
4. Michaelson NM and Connerney MA (2020) Glioblastoma multiforme that unusually present with radiographic dural tails: Questioning the diagnostic paradigm with a rare case report. Radiol Case Rep, 15:1087-90. [DOI:10.1016/j.radcr.2020.05.007] [PMID] []
5. Varatharaj C, Shwetha B, Rekha Reddy B, et al. (2016) Physical characteristics of photon and electron beams from a radiotherapy accelerator. International Journal of Medical Research and Review, 4:1178-88. [DOI:10.17511/ijmrr.2016.i07.18]
6. D'ávilaanunes M (2014) Hadron therapy physics and simulations. New York: Springer. [DOI:10.1007/978-1-4614-8899-6]
7. Yashar CM (2018) Basic principles in gynecologic radiotherapy. Clinical Gynecologic Oncology, Elsevier Inc, p. 586-605.e3. [DOI:10.1016/B978-0-323-40067-1.00023-1]
8. Kugerman MM and Sternhagen CJ (1976) Radiation Oncology. The Physiopathology of Cancer: Diagnosis, Treatment, Prevention, 2:135-81. [DOI:10.1159/000395011]
9. Greiner R, Blattmann H, Coray A, et al. (1990) Anaplastic astrocytoma and glioblastoma" pion irradiation with the dynamic conformation technique at the Swiss Institute for Nuclear Research (SIN). Radiotherapy and Oncology, 17: 37-46. [DOI:10.1016/0167-8140(90)90047-Z] [PMID]
10. Raju MR (1980) Heavy particle radiotherapy. New York: Academic Press.
11. Tsoulfanidis N and Landsberger S (2015) Measurement and detection of radiation. 4th ed. New York: CRC Press. [DOI:10.1201/b18203]
12. Krstic D and Nikezic D (2007) Input files with ORNL-mathematical phantoms of the human body for MCNP-4B. Comput Phys Commun, 176: 33-7. [DOI:10.1016/j.cpc.2006.06.016]
13. ICRP (2009) ICRP publication 110: Adult Reference Computational Phantoms. vol. 39. Polestar Wheatons Ltd.
14. Maughan RL, Chuba PJ, Porter AT, et al. (1997) The elemental composition of tumors: Kerma data for neutrons. Med Phys, 24:1241-4. [DOI:10.1118/1.598144] [PMID]
15. Harrison RW and Lobb DE (1973) A negative pion beam transport channel for radiobiology and radiation therapy at triumf. [DOI:10.1109/TNS.1973.4327317]
16. Marks LB, Yorke ED, Jackson A, et al. (2010) Use of normal tissue complication probability models in the clinic. Int J Radiat Oncolo Biolo Phys, 76: S10-9. [DOI:10.1016/j.ijrobp.2009.07.1754] [PMID] []
17. William (2019) Dose and irradiation analysis on carbon ion radiotherapy toward boron neutron capture therapy using SHIELD-HIT12A program. Universitas Gadjah Mada: Yogyakarta.
18. Muhammad I (2022) Dose and irradiation time analysis of proton therapy in cervical cancer using PHITS. Universitas Gadjah Mada: Yogyakarta.

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